Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation

Autor: Kati-Sisko Vellonen, Eva Ramsay, Susanna Boman, Marja Hagström, Arto Urtti, Marika Ruponen, Elisa Toropainen, Heidi Kidron, Eva M. del Amo

Publikováno v: Ramsay, E, Hagström, M, Vellonen, K S, Boman, S, Toropainen, E, del Amo, E M, Kidron, H, Urtti, A & Ruponen, M 2019, ' Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 143, pp. 18-23 . https://doi.org/10.1016/j.ejpb.2019.08.008
European Journal of Pharmaceutics and Biopharmaceutics

Retinal pigment epithelium (RPE) is a major part of blood-retinal barrier that affects drug elimination from the vitreous to the blood and drug distribution from blood circulation into the eye. Even though drug clearance from the vitreous has been we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e5f87cab19c6f9fb0e1119ccfb8536
https://www.research.manchester.ac.uk/portal/en/publications/role-of-retinal-pigment-epithelium-permeability-in-drug-transfer-between-posterior-eye-segment-and-systemic-blood-circulation(227dbf49-0590-44f2-8562-98a17464d2aa).html

Enhanced Polyamine Catabolism Alters Homeostatic Control of White Adipose Tissue Mass, Energy Expenditure, and Glucose Metabolism▿

Autor: Juhani Jänne, Eija Pirinen, Mikko I. Kettunen, Esa Hohtola, Teemu Kuulasmaa, Antti Virkamäki, Paula Itkonen, Maija Tusa, Seppo Ylä-Herttuala, Jyrki Parkkinen, J. Kalervo Hiltunen, Kirsi Niiranen, Susanna Boman, Anna-Liisa Levonen, Szabolcs Fatrai, Ulf Smith, Joanna Skommer, Markku Laakso, Leena Alhonen, Emilia Kansanen, Marko Pietilä, Suvi Koota, Sami Heikkinen

Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) is an attractive candidate gene for type 2 diabetes, as genes of the oxidative phosphorylation (OXPHOS) pathway are coordinatively downregulated by reduced expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b866fedcc54c88e16af8b7e2bd617db8
https://europepmc.org/articles/PMC1951486/