Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Susanna, Brighenti"'
Autor:
Sadaf Kalsum, Mira Akber, Marco Giulio Loreti, Blanka Andersson, Eva Danielson, Maria Lerm, Susanna Brighenti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Host-directed therapies aiming to strengthen the body’s immune system, represent an underexplored opportunity to improve treatment of tuberculosis (TB). We have previously shown in Mycobacterium tuberculosis (Mtb)-infection models and clin
Externí odkaz:
https://doaj.org/article/97b2c344b16042e3834c7798655b9761
Autor:
Senait Ashenafi, Marco Giulio Loreti, Amsalu Bekele, Getachew Aseffa, Wondwossen Amogne, Endale Kassa, Getachew Aderaye, Susanna Brighenti
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundImmune control of Mycobacterium tuberculosis (Mtb) infection is largely influenced by the extensive disease heterogeneity that is typical for tuberculosis (TB). In this study, the peripheral inflammatory immune profile of different sub-grou
Externí odkaz:
https://doaj.org/article/c1c41870d61445e6b705beb0fc6ef872
Autor:
Laura M. Palma Medina, Haris Babačić, Majda Dzidic, Åsa Parke, Marina Garcia, Kimia T. Maleki, Christian Unge, Magda Lourda, Egle Kvedaraite, Puran Chen, Jagadeeswara Rao Muvva, Martin Cornillet, Johanna Emgård, Kirsten Moll, Karolinska K. I./K. COVID-19 Study Group, Jakob Michaëlsson, Malin Flodström-Tullberg, Susanna Brighenti, Marcus Buggert, Jenny Mjösberg, Karl-Johan Malmberg, Johan K. Sandberg, Sara Gredmark-Russ, Olav Rooyackers, Mattias Svensson, Benedict J. Chambers, Lars I. Eriksson, Maria Pernemalm, Niklas K. Björkström, Soo Aleman, Hans-Gustaf Ljunggren, Jonas Klingström, Kristoffer Strålin, Anna Norrby-Teglund
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background COVID-19 remains a major public health challenge, requiring the development of tools to improve diagnosis and inform therapeutic decisions. As dysregulated inflammation and coagulation responses have been implicated in the pathoph
Externí odkaz:
https://doaj.org/article/d9502f7d22f248878bad4b825dd78148
Autor:
Senait Ashenafi, Susanna Brighenti
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tuberculosis (TB) remains one of the deadliest infectious diseases in the world and every 20 seconds a person dies from TB. An important attribute of human TB is induction of a granulomatous inflammation that creates a dynamic range of local microenv
Externí odkaz:
https://doaj.org/article/4187dd7db230401db797d811c4108dea
Autor:
Graciela Terán, Hanxiong Li, Sergiu-Bogdan Catrina, Ruining Liu, Susanna Brighenti, Xiaowei Zheng, Jakob Grünler, Susanne Nylén, Berit Carow, Martin E. Rottenberg
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Diabetes mellitus (DM) increases the risk of developing tuberculosis (TB), but the mechanisms behind diabetes-TB comorbidity are still undefined. Here, we studied the role of hypoxia-inducible factor-1 (HIF-1), a main regulator of metabolic
Externí odkaz:
https://doaj.org/article/3c79e6a54a8b467baaa861f0f21a88de
Autor:
Akhirunnesa Mily, Protim Sarker, Inin Taznin, Delwar Hossain, Md. Ahsanul Haq, S. M. Mostofa Kamal, Birgitta Agerberth, Susanna Brighenti, Rubhana Raqib
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background Diabetes mellitus type 2 (DM) may impede immune responses in tuberculosis (TB) and thus contribute to enhanced disease severity. In this study, we aimed to evaluate DM-mediated alterations in clinical, radiological and immunologic
Externí odkaz:
https://doaj.org/article/a2c605d95c754e9abddc81b2898772cd
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Chronic lung diseases are a leading cause of morbidity and mortality across the globe, encompassing a diverse range of conditions from infections with pathogenic microorganisms to underlying genetic disorders. The respiratory tract represents an acti
Externí odkaz:
https://doaj.org/article/a1b1b3b4a23142bb985467f9123347ac
Autor:
Jagadeeswara Rao Muvva, Venkata Ramanarao Parasa, Maria Lerm, Mattias Svensson, Susanna Brighenti
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Background: Understanding macrophage behavior is key to decipher Mycobacterium tuberculosis (Mtb) pathogenesis. We studied the phenotype and ability of human monocyte-derived cells polarized with active vitamin D [1,25(OH)2D3] to control intracellula
Externí odkaz:
https://doaj.org/article/0167709d1f644c339de27643917f74b5
Autor:
Lalit Rane, Sayma Rahman, Isabelle Magalhaes, Aditya Ambati, Jan Andersson, Alimuddin Zumla, Susanna Brighenti, Markus J. Maeurer
Publikováno v:
International Journal of Infectious Diseases, Vol 59, Iss C, Pp 29-36 (2017)
Objectives: The 6-exon-spanning ‘canonical’ Interleukin-7 (IL-7c) is a non-redundant cytokine in human T-cell homeostasis that undergoes extensive alternative pre-mRNA splicing. The IL-7 gene variant lacking, exon 5 (IL-7δ5), exhibits agonistic
Externí odkaz:
https://doaj.org/article/3569003393c34aac9ed7dc7c80cc3768
Autor:
Davide Valentini, Martin Rao, Lalit Rane, Sayma Rahman, Rebecca Axelsson-Robertson, Rainer Heuchel, Matthias Löhr, Daniel Hoft, Susanna Brighenti, Alimuddin Zumla, Markus Maeurer
Publikováno v:
International Journal of Infectious Diseases, Vol 56, Iss C, Pp 140-154 (2017)
Background: Bacille Calmette–Guérin (BCG) is the world’s most widely distributed vaccine, used against tuberculosis (TB), in cancer immunotherapy, and in autoimmune diseases due to its immunomodulatory properties. To date, the effect of BCG vacc
Externí odkaz:
https://doaj.org/article/99991500ccf84e228d53eb86783f4ded