Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Susann Szmania"'
Autor:
Amberly Moreno-Bost, Frits van Rhee, Giridhararao Jayandharan, Ramesh B. Batchu, Scott A. Gruber, Susann Szmania, Donald W. Weaver, Oksana V. Gruzdyn, Arun Srivastava, Bala K. Kolli
Publikováno v:
Vaccine. 32:938-943
MAGE-A3 is highly expressed in epithelial ovarian cancer (EOC), making it a promising candidate for immunotherapy. We investigated whether dendritic cells (DCs) transduced with a rAAV-6 capsid mutant vector Y445F could elicit effective MAGE-A3-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82badc2fe79746c516a67728eab58fa7
https://doi.org/10.1016/j.vaccine.2013.12.049
https://doi.org/10.1016/j.vaccine.2013.12.049
Publikováno v:
Critical Reviews in Oncogenesis. 19:121-132
Natural killer (NK) cells have been shown to have important functions in anti-tumor responses and therefore have been used as adoptive immunotherapy for cancer. Here, we review the current methods of ex vivo activation, enrichment, expansion, and shi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcb772e8e790e331e0a9d8fc56b5030
https://doi.org/10.1615/critrevoncog.2014010931
https://doi.org/10.1615/critrevoncog.2014010931
Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications
Autor:
Susann Szmania, Juan F. Vera, Dario Campana, Natalia Lapteva, Elaine Coustan-Smith, April G. Durett, Amberly Moreno-Bost, Minhtran C. Ngo, Jiali Sun, Leslie L. Huye, Adrian P. Gee, Jun Ando, Lisa Rollins, Frits Vanrhee, Cliona M. Rooney, Jian Fang, Zhuyong Mei, Tarun K. Garg, Varada Dandekar, Kimberley Jackson
Publikováno v:
Cytotherapy. 14:1131-1143
Interest in natural killer (NK) cell-based immunotherapy has resurged since new protocols for the purification and expansion of large numbers of clinical-grade cells have become available.We have successfully adapted a previously described NK expansi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7f76f3c0b4608cbc05773776cd59f5
https://doi.org/10.3109/14653249.2012.700767
https://doi.org/10.3109/14653249.2012.700767
Autor:
H. Grant Prentice, Bart Barlogie, Antje Hoerring, Jackie Szymonifka, John D. Shaughnessy, Frits van Rhee, Amberly Moreno-Bost, Katie L. Stone, Tarun K. Garg, Susann Szmania
Publikováno v:
Cytotherapy. 13:618-628
Immunotherapy targeting MAGE-A3 in multiple myeloma (MM) could eradicate highly aggressive and proliferative clonal cell populations responsible for relapse. However, expression of many cancer-testis antigens, including MAGE-A3, can be heterogeneous,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a3d55d06f38a0310346beeab43e0e1
https://doi.org/10.3109/14653249.2010.529893
https://doi.org/10.3109/14653249.2010.529893
Autor:
Nancy Rosen, Michele Cottler-Fox, Guido Tricot, Bart Barlogie, Sanjaya Viswamitra, Frits van Rhee, Qing Yi, Susann Szmania, Jianfei Qian, John Freeman
Publikováno v:
British Journal of Haematology. 150:554-564
Vaccination with idiotype (Id) protein-pulsed dendritic cells (DCs) has been explored in multiple myeloma and the results have been disappointing. To improve the efficacy of DC vaccination in myeloma, we investigated the use of Id- and keyhole limpet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29d85b102e179650123e58f00b781c57
https://doi.org/10.1111/j.1365-2141.2010.08286.x
https://doi.org/10.1111/j.1365-2141.2010.08286.x
Autor:
Shankar Kumar, Gao Liu, Anne van Abbema, Susan Rhodes, Vladimir Vexler, Amulya Nanisetti, Benny P. Shum, John D. Shaughnessy, Melanie Wong, Naoya Tsurushita, Fenghuang Zhan, Shihao Chen, Daniel E. H. Afar, Aparna Draksharapu, Audie Rice, Mahrukh Huseni, David M. W. Powers, Bart Barlogie, Yin Zhang, Balaji Balasa, Marna Williams, Franklin Fuh, Mohamad A. Hussein, Eric D. Hsi, Roxanne Steinle, Susann Szmania, Myles B.C. Dillon, Frits van Rhee
Publikováno v:
Clinical Cancer Research. 14:2775-2784
Purpose: We generated a humanized antibody, HuLuc63, which specifically targets CS1 (CCND3 subset 1, CRACC, and SLAMF7), a cell surface glycoprotein not previously associated with multiple myeloma. To explore the therapeutic potential of HuLuc63 in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51201b042fb124cd1c452c079014fcf
https://doi.org/10.1158/1078-0432.ccr-07-4246
https://doi.org/10.1158/1078-0432.ccr-07-4246
Autor:
Jumei Shi, Priyangi A. Malaviarachchi, John D. Shaughnessy, Brian Storrie, Arend Mulder, Bart Barlogie, Tarun K. Garg, Frits van Rhee, Susann Szmania, Rachel E. Kellum, Guido Tricot
Publikováno v:
Blood. 111:1309-1317
Human leukocyte antigen class I molecules expressed by tumor cells play a central role in the regulation of natural killer (NK) cell–mediated immune responses. The proteasome inhibitor bortezomib has demonstrated significant activity in multiple my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfc1ae0ebcd9f95271a7719d6b8f106
https://doi.org/10.1182/blood-2007-03-078535
https://doi.org/10.1182/blood-2007-03-078535
Autor:
Lloyd J. Old, John D. Shaughnessy, Amberly Moreno, Frits van Rhee, Sacha Gnjatic, Brad Thuro, Guido Tricot, Jos Melenhorst, Katie L. Stone, John Barrett, Bart Barlogie, Fenghuang Zhan, Vincent Brichard, Susann Szmania
Publikováno v:
Journal of Immunotherapy. 30:847-854
MAGE-A3 is frequently expressed in high-risk multiple myeloma (MM). We immunized a healthy donor with MAGE-A3 protein formulated in AS02B to transfer immunity to her identical twin, diagnosed with MAGE-A3-positive MM. After a melphalan 200 mg/m synge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d208b05c12da039140496ab8f737db3
https://doi.org/10.1097/cji.0b013e318158fcff
https://doi.org/10.1097/cji.0b013e318158fcff
Autor:
Natalia Lapteva, Justin Stivers, Bijay Nair, Adrian P. Gee, Katie L. Stone, Susan Panozzo, Sarah Waheed, Frits van Rhee, Dario Campana, Susann Szmania, William T. Bellamy, Tarun K. Garg, Michele Cottler-Fox, Cliona M. Rooney, Emily Woods, Junaid A. Khan, Joshua Epstein, Molly Robbins, Amy D Greenway, Joshuah D Lingo, Shmuel Yaccoby, Bart Barlogie
Highly activated/expanded natural killer (NK) cells can be generated by stimulation with the human leukocyte antigen-deficient cell line K562, genetically modified to express 41BB-ligand and membrane-bound interleukin (IL)15. We tested the safety, pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b678cc01f6df65abd266e96161e48129
https://europepmc.org/articles/PMC4352951/
https://europepmc.org/articles/PMC4352951/
Publikováno v:
Leukemia & Lymphoma. 47:2037-2048
Most patients with poor-prognosis myeloma (abnormal metaphase cytogenetics) achieve excellent responses with tandem transplants, but the remissions are not durable. Novel interventions such as immunotherapy may eradicate the residual chemotherapy-res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7984a2daabb2590082dad95994e0aadd
https://doi.org/10.1080/10428190600742292
https://doi.org/10.1080/10428190600742292