Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Susann Schröder"'
Autor:
Daniel Gündel, Magali Toussaint, Thu Hang Lai, Winnie Deuther-Conrad, Paul Cumming, Susann Schröder, Rodrigo Teodoro, Rareş-Petru Moldovan, Francisco Pan-Montojo, Bernhard Sattler, Klaus Kopka, Osama Sabri, Peter Brust
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 516 (2022)
The cerebral expression of the A2A adenosine receptor (A2AAR) is altered in neurodegenerative diseases such as Parkinson’s (PD) and Huntington’s (HD) diseases, making these receptors an attractive diagnostic and therapeutic target. We aimed to fu
Externí odkaz:
https://doaj.org/article/e2058fe7ee934c008d6cd4ac33ced1b4
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3832 (2021)
Cyclic nucleotide phosphodiesterases (PDEs) represent one of the key targets in the research field of intracellular signaling related to the second messenger molecules cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP)
Externí odkaz:
https://doaj.org/article/de71802012cb4fd580460e904aa4ec24
Autor:
Thu Hang Lai, Susann Schröder, Magali Toussaint, Sladjana Dukić-Stefanović, Mathias Kranz, Friedrich-Alexander Ludwig, Steffen Fischer, Jörg Steinbach, Winnie Deuther-Conrad, Peter Brust, Rareş-Petru Moldovan
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2285 (2021)
The adenosine A2A receptor (A2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during t
Externí odkaz:
https://doaj.org/article/76b84321f4d2489c95d5100f3eac0c6c
Autor:
Susann Schröder, Thu Hang Lai, Magali Toussaint, Mathias Kranz, Alexandra Chovsepian, Qi Shang, Sladjana Dukić-Stefanović, Winnie Deuther-Conrad, Rodrigo Teodoro, Barbara Wenzel, Rareş-Petru Moldovan, Francisco Pan-Montojo, Peter Brust
Publikováno v:
Molecules, Vol 25, Iss 7, p 1633 (2020)
The adenosine A2A receptor (A2AR) is regarded as a particularly appropriate target for non-dopaminergic treatment of Parkinson’s disease (PD). An increased A2AR availability has been found in the human striatum at early stages of PD and in patients
Externí odkaz:
https://doaj.org/article/a6ba38be238e498699ccd57b2c5d72c9
Autor:
Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Rodrigo Teodoro, Ute Egerland, Mathias Kranz, Matthias Scheunemann, Norbert Höfgen, Jörg Steinbach, Peter Brust
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 9591-9615 (2015)
Phosphodiesterase 2A (PDE2A) is highly and specifically expressed in particular brain regions that are affected by neurological disorders and in certain tumors. Development of a specific PDE2A radioligand would enable molecular imaging of the PDE2A p
Externí odkaz:
https://doaj.org/article/287eedc5a653485480ce4d43236e0cb4
Autor:
Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Rodrigo Teodoro, Mathias Kranz, Matthias Scheunemann, Ute Egerland, Norbert Höfgen, Detlef Briel, Jörg Steinbach, Peter Brust
Publikováno v:
Molecules, Vol 23, Iss 3, p 556 (2018)
Specific radioligands for in vivo visualization and quantification of cyclic nucleotide phosphodiesterase 2A (PDE2A) by positron emission tomography (PET) are increasingly gaining interest in brain research. Herein we describe the synthesis, the 18F-
Externí odkaz:
https://doaj.org/article/df2b6a0b9d3d4755a29a5f00617e3629
Publikováno v:
Molecules, Vol 21, Iss 5, p 650 (2016)
Cyclic nucleotide phosphodiesterases (PDEs) are a class of intracellular enzymes that inactivate the secondary messenger molecules, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Thus, PDEs regulate the signaling cas
Externí odkaz:
https://doaj.org/article/080b80bcecf243f8bfa85a8ad9faca6a
Autor:
Jianrong Liu, Barbara Wenzel, Sladjana Dukic-Stefanovic, Rodrigo Teodoro, Friedrich-Alexander Ludwig, Winnie Deuther-Conrad, Susann Schröder, Jean-Michel Chezal, Emmanuel Moreau, Peter Brust, Aurélie Maisonial-Besset
Publikováno v:
Pharmaceuticals, Vol 9, Iss 2, p 22 (2016)
Phosphodiesterases (PDEs) are enzymes that play a major role in cell signalling by hydrolysing the secondary messengers cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP) throughout the body and brain. Altered cyclic n
Externí odkaz:
https://doaj.org/article/ee4229335f3542d7a23f1b8d68bef7d3
Autor:
Thu Hang, Lai, Susann, Schröder, Magali, Toussaint, Sladjana, Dukić-Stefanović, Mathias, Kranz, Friedrich-Alexander, Ludwig, Steffen, Fischer, Jörg, Steinbach, Winnie, Deuther-Conrad, Peter, Brust, Rareş-Petru, Moldovan
Publikováno v:
International Journal of Molecular Sciences
The adenosine A2A receptor (A2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::57128f2353b88fc33cb406f88172dbde
https://pubmed.ncbi.nlm.nih.gov/33669003
https://pubmed.ncbi.nlm.nih.gov/33669003
Autor:
Winnie Deuther-Conrad, Rareş-Petru Moldovan, Peter Brust, Friedrich-Alexander Ludwig, Sladjana Dukic-Stefanovic, Thu Hang Lai, Barbara Wenzel, Magali Toussaint, Bernhard Sattler, Susann Schröder, Osama Sabri, Björn H. Falkenburger, Daniel Gündel, Rodrigo Teodoro
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging 48(2021), 2727-2736
Purpose The adenosine A2A receptor has emerged as a therapeutic target for multiple diseases, and thus the non-invasive imaging of the expression or occupancy of the A2A receptor has potential to contribute to diagnosis and drug development. We aimed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c720591e36fa0fd6b1dee17b1209f14e
https://www.hzdr.de/publications/Publ-31989-1
https://www.hzdr.de/publications/Publ-31989-1
