Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Susana Velasco-Miguel"'
Autor:
Manuel Serrano, Lyubomir T. Vassilev, Daniel Herranz, Susana Velasco-Miguel, Ana Ortega-Molina, Alejo Efeyan
Cellular senescence is emerging as an important in vivo anticancer response elicited by multiple stresses, including currently used chemotherapeutic drugs. Nutlin-3a is a recently discovered small-molecule antagonist of the p53-destabilizing protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36117d56230306414fe5ec0bb534349d
https://doi.org/10.1158/0008-5472.c.6495480.v1
https://doi.org/10.1158/0008-5472.c.6495480.v1
Autor:
Manuel Serrano, Lyubomir T. Vassilev, Daniel Herranz, Susana Velasco-Miguel, Ana Ortega-Molina, Alejo Efeyan
Supplementary Figure 1 from Induction of p53-Dependent Senescence by the MDM2 Antagonist Nutlin-3a in Mouse Cells of Fibroblast Origin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a908a208a7a93c4ed2de14cb3c5c947
https://doi.org/10.1158/0008-5472.22367250.v1
https://doi.org/10.1158/0008-5472.22367250.v1
Autor:
Alberto Martín, Carolina Epifano, Borja Vilaplana-Marti, Iván Hernández, Rocío I. R. Macías, Ángel Martínez-Ramírez, Ana Cerezo, Pablo Cabezas-Sainz, Maria Garranzo-Asensio, Sandra Amarilla-Quintana, Déborah Gómez-Domínguez, Eduardo Caleiras, Jordi Camps, Gonzalo Gómez-López, Marta Gómez de Cedrón, Ana Ramírez de Molina, Rodrigo Barderas, Laura Sánchez, Susana Velasco-Miguel, Ignacio Pérez de Castro
Publikováno v:
Cell death and differentiation.
Despite being frequently observed in cancer cells, chromosomal instability (CIN) and its immediate consequence, aneuploidy, trigger adverse effects on cellular homeostasis that need to be overcome by anti-stress mechanisms. As such, these safeguard r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b79bb55b6d56b6a29cc47b38654a06
https://pubmed.ncbi.nlm.nih.gov/35869285
https://pubmed.ncbi.nlm.nih.gov/35869285
Autor:
Alexander Nikolayev, Ana Cerezo, Susana Velasco-Miguel, Juan M. Funes, Karim A. Benhadji, Sandaruwan Geeganage, Gloria Martinez-del Hoyo, Frank C. Dorsey, Raymond Gilmour, Henry James Robert, Kenneth D. Roth, Sandra Peregrina, Lillian Sams, Ramón Campos-Olivas, Laura Diezma
Publikováno v:
Cancer Research. 79:2187-2187
Tryptophan metabolism plays a central role in immunosuppression through the local depletion of tryptophan with the concomitant production and accumulation of kynurenine, both of which are immunosuppressive. Indoleamine 2,3-dioxygenase 1 (IDO1), a hem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e0cd7d0ee555ecbb2c64150cc54e3c2
https://doi.org/10.1158/1538-7445.am2019-2187
https://doi.org/10.1158/1538-7445.am2019-2187
Publikováno v:
Proceedings of the National Academy of Sciences. 105:9793-9798
The identification of new pharmacological approaches to effectively prevent, treat, and cure the metabolic syndrome is of crucial importance. Excessive exposure to dietary lipids causes inflammatory responses, deranges the homeostasis of cellular met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ae4bb77b117f202295a44647bbdc97
https://doi.org/10.1073/pnas.0802917105
https://doi.org/10.1073/pnas.0802917105
Autor:
Ana Ortega-Molina, Susana Velasco-Miguel, Alejo Efeyan, Lyubomir T. Vassilev, Daniel Herranz, Manuel Serrano
Publikováno v:
Cancer Research. 67:7350-7357
Cellular senescence is emerging as an important in vivo anticancer response elicited by multiple stresses, including currently used chemotherapeutic drugs. Nutlin-3a is a recently discovered small-molecule antagonist of the p53-destabilizing protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f6edaf5f61b073e4780cec98e9a094
https://doi.org/10.1158/0008-5472.can-07-0200
https://doi.org/10.1158/0008-5472.can-07-0200
Publikováno v:
Oncogene. 26:1645-1649
Protein p21Cip1/Waf1 is transcriptionally activated by the tumour suppressor p53 and previous studies have shown that p21 plays a role in tumour suppression. However, the involvement of p21 in p53-mediated tumour suppression remains to be directly de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f429cd642d173130382aa7b5f9d6e32e
https://doi.org/10.1038/sj.onc.1209972
https://doi.org/10.1038/sj.onc.1209972
Autor:
Susana Velasco-Miguel, R. Ilona Linnoila, Andrew D. Patterson, Albert J. Fornace, Robyn T. Philburn, M. Christine Hollander, Errol C. Friedberg
Publikováno v:
Proceedings of the National Academy of Sciences. 102:13200-13205
Chromosome 3p and 1p deletions are among the most frequent genetic changes in human lung cancer and although candidate tumor suppressor genes have been identified in these regions, no causative correlations have been drawn between deletion or mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f28579b21276d7dac39930db50feeaa
https://doi.org/10.1073/pnas.0503133102
https://doi.org/10.1073/pnas.0503133102
Autor:
Nicholas E. Geacintov, Zvi Livneh, Susana Velasco-Miguel, Sharon Avkin, Moshe Goldsmith, Errol C. Friedberg
Publikováno v:
Journal of Biological Chemistry. 279:53298-53305
Replication across unrepaired DNA lesions in mammalian cells is effected primarily by specialized, low fidelity DNA polymerases. We studied translesion DNA synthesis (TLS) across a benzo[a]pyrene-guanine (BP-G) adduct, a major mutagenic DNA lesion ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e56f6f18c5fb2abb4f50f05a65172add
https://doi.org/10.1074/jbc.m409155200
https://doi.org/10.1074/jbc.m409155200
Autor:
Susana Velasco-Miguel, Errol C. Friedberg, Dorit Nahari, Laurie B. Task, Russell L Daniel, Lisa D. McDaniel
Publikováno v:
DNA Repair. 3:379-386
Mutational hot spots in the human p53 gene are well established in tumors in the human population and are frequently negative prognosticators of the clinical outcome. We previously developed a mouse model of skin cancer with mutations in the xeroderm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0997e32c17da3e2cc69dfe6363ca961
https://doi.org/10.1016/j.dnarep.2003.03.001
https://doi.org/10.1016/j.dnarep.2003.03.001