Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Susana Ursua"'
Autor:
Raygene Martier, Jolanda M. Liefhebber, Ana García-Osta, Jana Miniarikova, Mar Cuadrado-Tejedor, Maria Espelosin, Susana Ursua, Harald Petry, Sander J. van Deventer, Melvin M. Evers, Pavlina Konstantinova
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 26-37 (2019)
A hexanucleotide GGGGCC expansion in intron 1 of chromosome 9 open reading frame 72 (C9orf72) gene is the most frequent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The corresponding repeat-containing sense and anti
Externí odkaz:
https://doaj.org/article/7205c963663e4645b6377c073cfd2e0c
Autor:
Maria Espelosin, Diego Sucunza, Marta Pérez-González, Mar Cuadrado-Tejedor, Susana Ursua, Rafael Luján, Sara Badesso, Miren Roldan, Maite Mendioroz, Ana Garcia-Osta
Publikováno v:
Progress in neurobiology. 191
Clinical studies revealed that some aged-individuals accumulate a significant number of histopathological Alzheimer´s disease (AD) lesions in their brain, yet without developing any signs of dementia. Animal models of AD represent suitable tools to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1c106f0b2201a0b4fc2bcdee828f75
https://pubmed.ncbi.nlm.nih.gov/32380223
https://pubmed.ncbi.nlm.nih.gov/32380223
Autor:
Ana Garcia-Osta, Irene de Miguel, Carolina García-Barroso, Julen Oyarzabal, Elena Sáez, Obdulia Rabal, Marta Pérez-González, Mar Cuadrado-Tejedor, Wu Wei, Maria Espelosin, Tan Haizhong, Ana Ugarte, Ander Estella-Hermoso de Mendoza, Susana Ursua, Juan A. Sánchez-Arias, Xu Musheng
Publikováno v:
European Journal of Medicinal Chemistry. 150:506-524
We have identified chemical probes that act as dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors (>1 log unit difference versus class I HDACs) to decipher the contribution of HDAC isoforms to the positive impact o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc24980e1b1ca1a4a39db01fb1bf214f
https://doi.org/10.1016/j.ejmech.2018.03.005
https://doi.org/10.1016/j.ejmech.2018.03.005
Autor:
Rafael Luján, Mercedes Lachén-Montes, Joaquín Fernández-Irigoyen, Maria Espelosin, Mar Cuadrado-Tejedor, Diego Sucunza, Susana Ursua, Sara Badesso, Enrique Santamaría, Rocío Alfaro-Ruiz, Marta Pérez-González, Ana Garcia-Osta
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11950, p 11950 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname
International Journal of Molecular Sciences
Volume 22
Issue 21
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname
Despite the well-accepted role of the two main neuropathological markers (β-amyloid and tau) in the progression of Alzheimer’s disease, the interaction and specific contribution of each of them is not fully elucidated. To address this question, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46df6ae3bec7f998e2666d0a13561c9d
https://doi.org/10.3390/ijms222111950
https://doi.org/10.3390/ijms222111950
Autor:
Ana Ugarte, Julen Oyarzabal, Tan Haizhong, Mar Cuadrado-Tejedor, Obdulia Rabal, Xu Musheng, Elena Sáez, Wu Wei, Irene de Miguel, Juan A. Sánchez-Arias, Ana Garcia-Osta, Marta Pérez-González, Susana Ursua, Maria Espelosin
Publikováno v:
ACS Chemical Neuroscience. 8:638-661
A novel systems therapeutics approach, involving simultaneous inhibition of phosphodiesterase 5 (PDE5) and histone deacetylase (HDAC), has been validated as a potentially novel therapeutic strategy for the treatment of Alzheimer's disease (AD). First
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c35a430eaaa05ef05a9fe4c39930ef
https://doi.org/10.1021/acschemneuro.6b00370
https://doi.org/10.1021/acschemneuro.6b00370
Autor:
Pavlina Konstantinova, Jana Miniarikova, Jolanda M. Liefhebber, Raygene Martier, Harald Petry, Mar Cuadrado-Tejedor, Susana Ursua, Ana Garcia-Osta, Sander J. H. van Deventer, Melvin M. Evers, Maria Espelosin
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
Consejo Superior de Investigaciones Científicas (CSIC)
Molecular Therapy. Nucleic Acids
Molecular Therapy-Nucleic Acids, 16, 26-37
Molecular Therapy: Nucleic Acids, Vol 16, Iss, Pp 26-37 (2019)
Consejo Superior de Investigaciones Científicas (CSIC)
Molecular Therapy. Nucleic Acids
Molecular Therapy-Nucleic Acids, 16, 26-37
Molecular Therapy: Nucleic Acids, Vol 16, Iss, Pp 26-37 (2019)
A hexanucleotide GGGGCC expansion in intron 1 of chromosome 9 open reading frame 72 (C9orf72) gene is the most frequent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The corresponding repeat-containing sense and anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2931cf771725146d835799792197e1
https://hdl.handle.net/10171/63714
https://hdl.handle.net/10171/63714
Autor:
Ana Ugarte, Elena Sáez, Ana Garcia-Osta, Irene de Miguel, Marta Pérez-González, Wu Wei, Tan Haizhong, Ander Estella-Hermoso de Mendoza, Mar Cuadrado-Tejedor, Julen Oyarzabal, Obdulia Rabal, Susana Ursua, Xu Musheng, Juan A. Sánchez-Arias, Maria Espelosin, Carolina García-Barroso
Publikováno v:
Journal of medicinal chemistry. 59(19)
Simultaneous inhibition of phosphodiesterase 5 (PDE5) and histone deacetylases (HDAC) has recently been validated as a potentially novel therapeutic approach for Alzheimer's disease (AD). To further extend this concept, we designed and synthesized th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a2b087ad51ce9d2b3d2ef5387fe0ef
https://pubmed.ncbi.nlm.nih.gov/27606546
https://pubmed.ncbi.nlm.nih.gov/27606546