Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Susana T Valente"'
Autor:
Susana T Valente, Sonia eMediouni, Courtney eMiller, Maria Cecilia G Marcondes, Jay eMcLaughlin
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Antiretroviral therapy (ART) has dramatically improved the lives of HIV-1 infected individuals. Nonetheless, HIV associated neurocognitive disorders (HAND), which range from undetectable neurocognitive impairments to severe dementia, still affect app
Externí odkaz:
https://doaj.org/article/9b5019d04d1f488ca8cd69652560b792
Autor:
Danielle E. Lyons, Priti Kumar, Nadia R. Roan, Patricia A. Defechereux, Cedric Feschotte, Ulrike C. Lange, Niren Murthy, Pauline Sameshima, Eric Verdin, Julie A. Ake, Matthew S. Parsons, Avindra Nath, Sara Gianella, Davey M. Smith, Esper G. Kallas, Thomas J. Villa, Richard Strange, Betty Mwesigwa, Robert L. Furler O’Brien, Douglas F. Nixon, Lishomwa C. Ndhlovu, Susana T. Valente, Melanie Ott
Publikováno v:
Viruses, Vol 15, Iss 11, p 2171 (2023)
Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound competent latent and transcriptionally active reservoir cells persevere despite antiretroviral therapy and rekindle infection due to inefficient proviral silencing. We p
Externí odkaz:
https://doaj.org/article/e4df173514554fe9824778fa69c18045
Autor:
Sonia Mediouni, Huihui Mou, Yuka Otsuka, Joseph Anthony Jablonski, Robert Scott Adcock, Lalit Batra, Dong-Hoon Chung, Christopher Rood, Ian Mitchelle S. de Vera, Ronald Rahaim Jr., Sultan Ullah, Xuerong Yu, Yulia A. Getmanenko, Nicole M. Kennedy, Chao Wang, Tu-Trinh Nguyen, Mitchell Hull, Emily Chen, Thomas D. Bannister, Pierre Baillargeon, Louis Scampavia, Michael Farzan, Susana T. Valente, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 8-19 (2022)
The severe acute respiratory syndrome coronavirus 2 responsible for COVID-19 remains a persistent threat to mankind, especially for the immunocompromised and elderly for which the vaccine may have limited effectiveness. Entry of SARS-CoV-2 requires a
Externí odkaz:
https://doaj.org/article/2347b83126774a29aab28c5d045a7718
Autor:
Lijun Ling, Ana R. Leda, Nurjahan Begum, Rae Ann Spagnuolo, Angela Wahl, J. Victor Garcia, Susana T. Valente
Publikováno v:
Viruses, Vol 15, Iss 4, p 950 (2023)
HIV resistance to the Tat inhibitor didehydro-cortistatin A (dCA) in vitro correlates with higher levels of Tat-independent viral transcription and a seeming inability to enter latency, which rendered resistant isolates more susceptible to CTL-mediat
Externí odkaz:
https://doaj.org/article/3c292db9c9e04774aacfab1e3bec23ba
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-17 (2019)
Abstract Background Transcription from the integrated HIV-1 promoter is directly governed by its chromatin environment, and the nucleosome-1 downstream from the transcription start site directly impedes transcription from the HIV-1 promoter. The HIV-
Externí odkaz:
https://doaj.org/article/bd89f041bef0467885c92585c7a4d6ee
Autor:
Cari F. Kessing, Christopher C. Nixon, Chuan Li, Perry Tsai, Hiroshi Takata, Guillaume Mousseau, Phong T. Ho, Jenna B. Honeycutt, Mohammad Fallahi, Lydie Trautmann, J. Victor Garcia, Susana T. Valente
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 600-611 (2017)
HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency establishment. We postulated a “block-and-lock” functional cure approach based on properties of the Tat inhibitor didehydro-Cortistatin A (dCA). HIV-1
Externí odkaz:
https://doaj.org/article/cebe15104b8a475f8f02836b6d2d8b8d
Autor:
Monique Nijhuis, Steven G. Deeks, Richard Dunham, Marein A. W. P. de Jong, Marein de Jong, Thanyawee Puthanakit, Mirko Paiardini, Santiago Perez Patrigeon, Krista L. Dong, Jan van Lunzen, Luke Jasenosky, Jessica Salzwedel, Simon Collins, Katharine J. Bar, Frank Mardarelli, Jeffrey T. Safrit, Jeremy Sugarman, Alex Schneider, Nancie M. Archin, Zaza M. Ndhlovu, Joel N. Blankson, Zabrina L. Brumme, Hans-Peter Kiem, Gaerolwe Masheto, Beatriz Mothe, Karine Dubé, Katherine Luzuriaga, Jennifer Power, Sarah Fidler, Richard Jefferys, Fu Sheng Wang, Jeff Taylor, Kumitaa Theva Das, Boro Dropulic, Kai Deng, Devi SenGupta, Sharon Lewin, Marina Caskey, Susana T. Valente, Siegfried Schwarze, Nicolas Chomont, R. Brad Jones, Ole S. Søgaard, Paula M. Cannon, Olivier Lambotte, Edward Nelson Kankaka, Gabriela Turk, Christina Antoniadi, Udom Likhitwonnawut, Caroline T. Tiemessen, Pablo Tebas, Rosanne Lamplough, Cissy Kityo, Fernanda Heloise Côrtes, Melannie Ott, Rose Nabatanzi, Oguzhan Latif Nuh, Mitch Matoga, Linos Vandekerckhove, J. Victor Garcia, Thumbi Ndung'u, Bonnie J. Howell, Aurelio Orta-Resendiz, Ricardo Sobhie Diaz, Michael Louella, Ann Chahroudi, Deborah Persaud, Stephan Dressler, Josephine Nabukenya, Sharon R Lewin
Publikováno v:
Nature Medicine. 27:2085-2098
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b45d4a1ed300ed64c27c2b6dc382ca1a
https://doi.org/10.1038/s41591-021-01590-5
https://doi.org/10.1038/s41591-021-01590-5
Autor:
Chuan Li, Luisa P. Mori, Shuang Lyu, Ronald Bronson, Adam J. Getzler, Matthew E. Pipkin, Susana T. Valente
Publikováno v:
Proceedings of the National Academy of Sciences. 120
HIV gene expression is modulated by the combinatorial activity of the HIV transcriptional activator, Tat, host transcription factors, and chromatin remodeling complexes. To identify host factors regulating HIV transcription, we used specific single-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a70c77301cc6838e61b6f3ea616e765
https://doi.org/10.1073/pnas.2217476120
https://doi.org/10.1073/pnas.2217476120
Autor:
Luisa Mori, Susana T. Valente
Publikováno v:
Viruses, Vol 12, Iss 5, p 529 (2020)
HIV-1 establishes a life-long infection when proviral DNA integrates into the host genome. The provirus can then either actively transcribe RNA or enter a latent state, without viral production. The switch between these two states is governed in grea
Externí odkaz:
https://doaj.org/article/b1b806df96514576a8612c6113e85898
Autor:
Zixuan Yuan, Mahmud Arif Pavel, Hao Wang, Jerome C. Kwachukwu, Sonia Mediouni, Joseph Anthony Jablonski, Kendall W. Nettles, Chakravarthy B. Reddy, Susana T. Valente, Scott B. Hansen
Publikováno v:
Communications Biology. 5
Abstract Hydroxychloroquine (HCQ), a drug used to treat lupus and malaria, was proposed as a treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy. In vitro, HCQ effectively inhibits viral entry, but its use in the clinic h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e264dc9145e33043d50b4163cdfcf3
https://doi.org/10.1038/s42003-022-03841-8
https://doi.org/10.1038/s42003-022-03841-8