Cell shape information is transduced through tension-independent mechanisms

Autor: Amit Ron, Evren U. Azeloglu, Rhodora C. Calizo, Mufeng Hu, Smiti Bhattacharya, Yibang Chen, Gomathi Jayaraman, Sunwoo Lee, Susana R. Neves-Zaph, Hong Li, Ronald E. Gordon, John C. He, James C. Hone, Ravi Iyengar

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

It is not known whether the shape of a cell can regulate cellular phenotype independently. Here, the authors show that culturing kidney podocytes or smooth muscle cells on 3-D biomimetic surfaces results in phenotypic changes and that cell shape is s

Externí odkaz: https://doaj.org/article/e603071ebf0d4ed3b0ea421e96a6072e

A novel secreted-cAMP pathway inhibits pulmonary hypertension via a feed-forward mechanism

Autor: Javier Milara, Sang-Yong Lee, Carlos Bueno-Beti, Susana R. Neves-Zaph, Jane A. Leopold, Yassine Sassi, Roger J. Hajjar, Carly Jones, Guillaume Bonnet, Marc Humbert, Peter Dorfmüller, Malik Bisserier, Lahouaria Hadri

Publikováno v: Cardiovasc Res

AIMS: Cyclic adenosine monophosphate (cAMP) is the predominant intracellular second messenger that transduces signals from Gs-coupled receptors. Intriguingly, there is evidence from various cell types that an extracellular cAMP pathway is active in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3106438e7f797040a5b48ee0f89cc03
https://europepmc.org/articles/PMC7314640/

Cell shape information is transduced through tension-independent mechanisms

Autor: Evren U. Azeloglu, Rhodora Cristina Calizo, Susana R. Neves-Zaph, Gomathi Jayaraman, Hong Li, James Hone, Sunwoo Lee, John Cijiang He, Ronald E. Gordon, Yibang Chen, Amit Ron, Ravi Iyengar, Smiti Bhattacharya, Mufeng Hu

Publikováno v: Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

The shape of a cell within tissues can represent the history of chemical and physical signals that it encounters, but can information from cell shape regulate cellular phenotype independently? Using optimal control theory to constrain reaction-diffus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e021dc487a3f539d21eaae114118375
http://europepmc.org/articles/PMC5732205

Phosphodiesterase Diversity and Signal Processing Within cAMP Signaling Networks

Autor: Susana R. Neves-Zaph

Publikováno v: Advances in Neurobiology ISBN: 9783319588094

A large number of neuromodulators activate G-protein coupled receptors (GPCRs) and mediate their cellular actions via the regulation of intracellular cAMP, the small highly diffusible second messenger. In fact, in the same neuron several different GP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af9b1e3bf5d3f864e553cdcf75940955
https://doi.org/10.1007/978-3-319-58811-7_1

Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory

Autor: Vibeke M. Bruinenberg, Edward F Linton, Yool Lee, George S. Baillie, Leonardo A. Guercio, Jennifer C. Tudor, Susana R. Neves-Zaph, Alan J. Park, Peter Meerlo, Robbert Havekes, Rosa E. Tolentino, Rolf T. Hansen, Ted Abel, Miles D. Houslay

Publikováno v: The Journal of Neuroscience, 36(34), 8936-8946. Oxford University Press
Havekes, R, Park, A J, Tolentino, R E, Bruinenberg, V M, Tudor, J C, Lee, Y, Hansen, R T, Guercio, L A, Linton, E, Neves-zaph, S R, Meerlo, P, Baillie, G S, Houslay, M D & Abel, T 2016, ' Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory ', Journal of Neuroscience, vol. 36, no. 34, pp. 8936-8946 . https://doi.org/10.1523/JNEUROSCI.0248-16.2016

Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial cA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f066094eb6b375ccc87e6f63868de2c7
https://research.rug.nl/en/publications/d36184e1-ab2b-4089-95ef-547641b3cc75