Three doses of BNT162b2 COVID-19 mRNA vaccine establish long-lasting CD8+ T cell immunity in CLL and MDS patients

Autor: Susana Patricia Amaya Hernandez, Ditte Stampe Hersby, Kamilla Kjærgaard Munk, Tripti Tamhane, Darya Trubach, Maria Tagliamonte, Luigi Buonaguro, Anne Ortved Gang, Sine Reker Hadrup, Sunil Kumar Saini

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

Patients with hematological malignancies are prioritized for COVID-19 vaccine due to their high risk for severe SARS-CoV-2 infection-related disease and mortality. To understand T cell immunity, its long-term persistence, and its correlation with ant

Externí odkaz: https://doaj.org/article/446f232763fe40f585f32949304fb662

SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients

Autor: Morten Nielsen, Susana Patricia Amaya Hernandez, Anne Ortved Gang, Helle Rus Povlsen, Ditte Stampe Hersby, Tripti Tamhane, Sunil Kumar Saini, Sine Reker Hadrup

Publikováno v: Saini, S K, Hersby, D S, Tamhane, T, Povlsen, H R, Amaya Hernandez, S P, Nielsen, M, Gang, A O & Hadrup, S R 2021, ' SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients ', Science immunology, vol. 6, no. 58, eabf7550, pp. 1-16 . https://doi.org/10.1126/sciimmunol.abf7550
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Saini, S K, Hersby, D S, Tamhane, T, Povlsen, H R, Amaya Hernandez, S P, Nielsen, M, Gang, A O & Hadrup, S R 2021, ' SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients ', Science immunology, vol. 6, no. 58, eabf7550 . https://doi.org/10.1126/sciimmunol.abf7550

T cells are important for effective viral clearance, elimination of virus-infected cells and long-term disease protection. To examine the full-spectrum of CD8+ T cell immunity in COVID-19, we experimentally evaluated 3141 major histocompatibility (MH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103014ddd0f84dc3bd5cbe8fef4a3434
https://curis.ku.dk/portal/da/publications/sarscov2-genomewide-t-cell-epitope-mapping-reveals-immunodominance-and-substantial-cd8-t-cell-activation-in-covid19-patients(ed878466-1db0-4ceb-bbee-d2134bc6cf8a).html