Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Susana Muñoz Maniega"'
Autor:
Hannah M. Smith, Joanna E. Moodie, Karla Monterrubio-Gómez, Danni A. Gadd, Robert F. Hillary, Aleksandra D. Chybowska, Daniel L. McCartney, Archie Campbell, Paul Redmond, Danielle Page, Adele Taylor, Janie Corley, Sarah E. Harris, Maria Valdés Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary, James P. Boardman, Donncha S. Mullin, Tom C. Russ, Simon R. Cox, Riccardo E. Marioni
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typically derived via penalis
Externí odkaz:
https://doaj.org/article/3c13220e7e174e5f8add934cd767d03c
Autor:
Angela C. C. Jochems, Susana Muñoz Maniega, Una Clancy, Carmen Arteaga, Daniela Jaime Garcia, Francesca M. Chappell, Will Hewins, Rachel Locherty, Ellen V. Backhouse, Gayle Barclay, Charlotte Jardine, Donna McIntyre, Iona Gerrish, Agniete Kampaite, Eleni Sakka, Maria Valdés Hernández, Stewart Wiseman, Mark E. Bastin, Michael S. Stringer, Michael J. Thrippleton, Fergus N. Doubal, Joanna M. Wardlaw
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)
Background White matter hyperintensities (WMHs) might regress and progress contemporaneously, but we know little about underlying mechanisms. We examined WMH change and underlying quantitative magnetic resonance imaging tissue measures over 1 year in
Externí odkaz:
https://doaj.org/article/dcfe426c30cb4135a01b525bb04196f4
Autor:
Daniel L. McCartney, Robert F. Hillary, Eleanor L. S. Conole, Daniel Trejo Banos, Danni A. Gadd, Rosie M. Walker, Cliff Nangle, Robin Flaig, Archie Campbell, Alison D. Murray, Susana Muñoz Maniega, María del C. Valdés-Hernández, Mathew A. Harris, Mark E. Bastin, Joanna M. Wardlaw, Sarah E. Harris, David J. Porteous, Elliot M. Tucker-Drob, Andrew M. McIntosh, Kathryn L. Evans, Ian J. Deary, Simon R. Cox, Matthew R. Robinson, Riccardo E. Marioni
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background Blood-based markers of cognitive functioning might provide an accessible way to track neurodegeneration years prior to clinical manifestation of cognitive impairment and dementia. Results Using blood-based epigenome-wide analyses
Externí odkaz:
https://doaj.org/article/3e2cf700f20647cfac7e3fa529222f6d
Autor:
Abbie Barnes, Lucia Ballerini, Maria del C. Valdés Hernández, Francesca M. Chappell, Susana Muñoz Maniega, Rozanna Meijboom, Ellen V. Backhouse, Michael S. Stringer, Roberto Duarte Coello, Rosalind Brown, Mark E. Bastin, Simon R. Cox, Ian J. Deary, Joanna M. Wardlaw
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Enlarged perivascular spaces (PVS) and white matter hyperintensities (WMH) are features of cerebral small vessel disease which can be seen in brain magnetic resonance imaging (MRI). Given the associations and proposed mechanistic link between PVS and
Externí odkaz:
https://doaj.org/article/44173540b71743ea9b613ee754e33df1
Autor:
Muralidharan Sargurupremraj, Hideaki Suzuki, Xueqiu Jian, Chloé Sarnowski, Tavia E. Evans, Joshua C. Bis, Gudny Eiriksdottir, Saori Sakaue, Natalie Terzikhan, Mohamad Habes, Wei Zhao, Nicola J. Armstrong, Edith Hofer, Lisa R. Yanek, Saskia P. Hagenaars, Rajan B. Kumar, Erik B. van den Akker, Rebekah E. McWhirter, Stella Trompet, Aniket Mishra, Yasaman Saba, Claudia L. Satizabal, Gregory Beaudet, Laurent Petit, Ami Tsuchida, Laure Zago, Sabrina Schilling, Sigurdur Sigurdsson, Rebecca F. Gottesman, Cora E. Lewis, Neelum T. Aggarwal, Oscar L. Lopez, Jennifer A. Smith, Maria C. Valdés Hernández, Jeroen van der Grond, Margaret J. Wright, Maria J. Knol, Marcus Dörr, Russell J. Thomson, Constance Bordes, Quentin Le Grand, Marie-Gabrielle Duperron, Albert V. Smith, David S. Knopman, Pamela J. Schreiner, Denis A. Evans, Jerome I. Rotter, Alexa S. Beiser, Susana Muñoz Maniega, Marian Beekman, Julian Trollor, David J. Stott, Meike W. Vernooij, Katharina Wittfeld, Wiro J. Niessen, Aicha Soumaré, Eric Boerwinkle, Stephen Sidney, Stephen T. Turner, Gail Davies, Anbupalam Thalamuthu, Uwe Völker, Mark A. van Buchem, R. Nick Bryan, Josée Dupuis, Mark E. Bastin, David Ames, Alexander Teumer, Philippe Amouyel, John B. Kwok, Robin Bülow, Ian J. Deary, Peter R. Schofield, Henry Brodaty, Jiyang Jiang, Yasuharu Tabara, Kazuya Setoh, Susumu Miyamoto, Kazumichi Yoshida, Manabu Nagata, Yoichiro Kamatani, Fumihiko Matsuda, Bruce M. Psaty, David A. Bennett, Philip L. De Jager, Thomas H. Mosley, Perminder S. Sachdev, Reinhold Schmidt, Helen R. Warren, Evangelos Evangelou, David-Alexandre Trégouët, International Network against Thrombosis (INVENT) Consortium, International Headache Genomics Consortium (IHGC), Mohammad A. Ikram, Wei Wen, Charles DeCarli, Velandai K. Srikanth, J. Wouter Jukema, Eline P. Slagboom, Sharon L. R. Kardia, Yukinori Okada, Bernard Mazoyer, Joanna M. Wardlaw, Paul A. Nyquist, Karen A. Mather, Hans J. Grabe, Helena Schmidt, Cornelia M. Van Duijn, Vilmundur Gudnason, William T. Longstreth, Lenore J. Launer, Mark Lathrop, Sudha Seshadri, Christophe Tzourio, Hieab H. Adams, Paul M. Matthews, Myriam Fornage, Stéphanie Debette
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and
Externí odkaz:
https://doaj.org/article/3d0e1a5389ab4d9387592a6316f6a661
Autor:
Angela C.C. Jochems, Susana Muñoz Maniega, Maria del C Valdés Hernández, Gayle Barclay, Devasuda Anblagan, Lucia Ballerini, Rozanna Meijboom, Stewart Wiseman, Adele M. Taylor, Janie Corley, Francesca M. Chappell, Ellen V. Backhouse, Michael S. Stringer, David Alexander Dickie, Mark E. Bastin, Ian J. Deary, Simon R. Cox, Joanna M. Wardlaw
Publikováno v:
NeuroImage: Clinical, Vol 34, Iss , Pp 103019- (2022)
Lateral ventricles might increase due to generalized tissue loss related to brain atrophy. Alternatively, they may expand into areas of tissue loss related to white matter hyperintensities (WMH).We assessed longitudinal associations between lateral v
Externí odkaz:
https://doaj.org/article/e5921096af404d4e9477fb72e0444b19
Autor:
Sarah E. Harris, Simon R. Cox, Steven Bell, Riccardo E. Marioni, Bram P. Prins, Alison Pattie, Janie Corley, Susana Muñoz Maniega, Maria Valdés Hernández, Zoe Morris, Sally John, Paola G. Bronson, Elliot M. Tucker-Drob, John M. Starr, Mark E. Bastin, Joanna M. Wardlaw, Adam S. Butterworth, Ian J. Deary
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Late-life cognitive dysfunction is common, but the biological substrates are largely unknown. Here, the authors examined a panel of 90 neurology-related protein biomarkers and show that plasma levels of 22 of these proteins are associated with genera
Externí odkaz:
https://doaj.org/article/c6b4fb64963a4ad99c5b0ef50dad5ac9
Autor:
Angela C. C. Jochems, Susana Muñoz Maniega, Una Clancy, Daniela Jaime Garcia, Carmen Arteaga, Will Hewins, Rachel Penman, Olivia K. L. Hamilton, Agnieszka Czechoń, Ellen V. Backhouse, Michael J. Thrippleton, Michael S. Stringer, Mark. E. Bastin, Maria del C. Valdés Hernández, Stewart Wiseman, Francesca M. Chappell, Fergus N. Doubal, Joanna M. Wardlaw
Publikováno v:
Life, Vol 12, Iss 9, p 1362 (2022)
Post-stroke cognitive impairment is common and can have major impact on life after stroke. Peak-width of Skeletonized Mean Diffusivity (PSMD) is a diffusion imaging marker of white matter microstructure and is also associated with cognition. Here, we
Externí odkaz:
https://doaj.org/article/39d998212b0c4884847f3a71ceb51eb9
Autor:
Emily Wheater, Susan D. Shenkin, Susana Muñoz Maniega, Maria Valdés Hernández, Joanna M. Wardlaw, Ian J. Deary, Mark E. Bastin, James P. Boardman, Simon R. Cox
Publikováno v:
NeuroImage: Clinical, Vol 31, Iss , Pp 102776- (2021)
Birth weight, an indicator of fetal growth, is associated with cognitive outcomes in early life (which are predictive of cognitive ability in later life) and risk of metabolic and cardiovascular disease across the life course. Brain health in older a
Externí odkaz:
https://doaj.org/article/84f511969fb84417b08e8f1731259d05
Autor:
Lucia Ballerini, Sarah McGrory, Maria del C. Valdés Hernández, Ruggiero Lovreglio, Enrico Pellegrini, Tom MacGillivray, Susana Muñoz Maniega, Ross Henderson, Adele Taylor, Mark E. Bastin, Fergus Doubal, Emanuele Trucco, Ian J. Deary, Joanna Wardlaw
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 1, Iss , Pp 100002- (2020)
Background: Perivascular Spaces (PVS) become increasingly visible with advancing age on brain MRI, yet their relationship to morphological changes in the underlying microvessels remains poorly understood. Retinal and cerebral microvessels share morph
Externí odkaz:
https://doaj.org/article/69e1ce205ed647c8850168a7eae0bfbf