Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health

Autor: Hannah M. Smith, Joanna E. Moodie, Karla Monterrubio-Gómez, Danni A. Gadd, Robert F. Hillary, Aleksandra D. Chybowska, Daniel L. McCartney, Archie Campbell, Paul Redmond, Danielle Page, Adele Taylor, Janie Corley, Sarah E. Harris, Maria Valdés Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary, James P. Boardman, Donncha S. Mullin, Tom C. Russ, Simon R. Cox, Riccardo E. Marioni

Publikováno v: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-10 (2024)

Abstract Background Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typically derived via penalis

Externí odkaz: https://doaj.org/article/3c13220e7e174e5f8add934cd767d03c

Impact of white matter hyperintensity regression on global cognition, processing speed and executive function

Autor: Angela Jochems, Susana Muñoz Maniega, Una Clancy, Daniela Jaime Garcia, Carmen Arteaga, Mariadel C. Valdés Hernández, Will Hewins, Rachel Penman, Ellen Backhouse, Stewart Wiseman, Michael Thrippleton, Michael Stringer, Francesca Chappell, Fergus Doubal, Joanna Wardlaw

Publikováno v: Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100243- (2024)

Introduction: White matter hyperintensities (WMH) are related to cognitive decline, particularly processing speed and executive functioning (EF). However, all cognitive domains might be affected. WMH can regress and this might have positive consequen

Externí odkaz: https://doaj.org/article/cdfa1742bc5f4ccab31238ff7e761651

LA MEDIACIÓN COMO INSTANCIA PARA LA REVALORIZACIÓN DEL ROL PATERNO. ESTUDIO EXPLORATORIO-DOCUMENTAL

Autor: Susana Muñoz Seguel, Romanette Figueroa Guzmán, Mirta Ojeda Ovando, Abdy Troncoso Cordova

Publikováno v: Revista Chilena de Derecho y Ciencia Política, Vol 2, Iss 2 (2023)

Este estudio exploratorio explicativo, pretende conocer el efecto de la Me-diación Familiar, en la revalorización del rol paterno, las relaciones coparen-tales y el interés superior de los hijos.Con enfoque cualitativo interpretativo y análisis d

Externí odkaz: https://doaj.org/article/55d69b20828f4572ac8c2bec0706fc36

Uncertainty quantification for White Matter Hyperintensity segmentation detects silent failures and improves automated Fazekas quantification

Autor: Philps, Ben, Hernandez, Maria del C. Valdes, Qin, Chen, Clancy, Una, Sakka, Eleni, Maniega, Susana Munoz, Bastin, Mark E., Jochems, Angela C. C., Wardlaw, Joanna M., Bernabeu, Miguel O., Initiative, Alzheimers Disease Neuroimaging

White Matter Hyperintensities (WMH) are key neuroradiological markers of small vessel disease present in brain MRI. Assessment of WMH is important in research and clinics. However, WMH are challenging to segment due to their high variability in shape

Externí odkaz: http://arxiv.org/abs/2411.17571

Cerebral small vessel disease genomics and its implications across the lifespan

Autor: Muralidharan Sargurupremraj, Hideaki Suzuki, Xueqiu Jian, Chloé Sarnowski, Tavia E. Evans, Joshua C. Bis, Gudny Eiriksdottir, Saori Sakaue, Natalie Terzikhan, Mohamad Habes, Wei Zhao, Nicola J. Armstrong, Edith Hofer, Lisa R. Yanek, Saskia P. Hagenaars, Rajan B. Kumar, Erik B. van den Akker, Rebekah E. McWhirter, Stella Trompet, Aniket Mishra, Yasaman Saba, Claudia L. Satizabal, Gregory Beaudet, Laurent Petit, Ami Tsuchida, Laure Zago, Sabrina Schilling, Sigurdur Sigurdsson, Rebecca F. Gottesman, Cora E. Lewis, Neelum T. Aggarwal, Oscar L. Lopez, Jennifer A. Smith, Maria C. Valdés Hernández, Jeroen van der Grond, Margaret J. Wright, Maria J. Knol, Marcus Dörr, Russell J. Thomson, Constance Bordes, Quentin Le Grand, Marie-Gabrielle Duperron, Albert V. Smith, David S. Knopman, Pamela J. Schreiner, Denis A. Evans, Jerome I. Rotter, Alexa S. Beiser, Susana Muñoz Maniega, Marian Beekman, Julian Trollor, David J. Stott, Meike W. Vernooij, Katharina Wittfeld, Wiro J. Niessen, Aicha Soumaré, Eric Boerwinkle, Stephen Sidney, Stephen T. Turner, Gail Davies, Anbupalam Thalamuthu, Uwe Völker, Mark A. van Buchem, R. Nick Bryan, Josée Dupuis, Mark E. Bastin, David Ames, Alexander Teumer, Philippe Amouyel, John B. Kwok, Robin Bülow, Ian J. Deary, Peter R. Schofield, Henry Brodaty, Jiyang Jiang, Yasuharu Tabara, Kazuya Setoh, Susumu Miyamoto, Kazumichi Yoshida, Manabu Nagata, Yoichiro Kamatani, Fumihiko Matsuda, Bruce M. Psaty, David A. Bennett, Philip L. De Jager, Thomas H. Mosley, Perminder S. Sachdev, Reinhold Schmidt, Helen R. Warren, Evangelos Evangelou, David-Alexandre Trégouët, International Network against Thrombosis (INVENT) Consortium, International Headache Genomics Consortium (IHGC), Mohammad A. Ikram, Wei Wen, Charles DeCarli, Velandai K. Srikanth, J. Wouter Jukema, Eline P. Slagboom, Sharon L. R. Kardia, Yukinori Okada, Bernard Mazoyer, Joanna M. Wardlaw, Paul A. Nyquist, Karen A. Mather, Hans J. Grabe, Helena Schmidt, Cornelia M. Van Duijn, Vilmundur Gudnason, William T. Longstreth, Lenore J. Launer, Mark Lathrop, Sudha Seshadri, Christophe Tzourio, Hieab H. Adams, Paul M. Matthews, Myriam Fornage, Stéphanie Debette

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and

Externí odkaz: https://doaj.org/article/3d0e1a5389ab4d9387592a6316f6a661