Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Susana Llanos"'
Autor:
Susana Llanos, Bruno Di Geronimo, Ester Casajús, Elena Blanco-Romero, Rafael Fernández-Leiro, Juan Méndez
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The COVID-19 pandemic highlighted the need for the rapid development of antiviral therapies. Viral RNA-dependent RNA polymerases (RdRp) are promising targets, and numerous virtual screenings for potential inhibitors were conducted without va
Externí odkaz:
https://doaj.org/article/c3f6737d88c2478690195abeaf125408
Autor:
Francisco Triana-Martínez, Pilar Picallos-Rabina, Sabela Da Silva-Álvarez, Federico Pietrocola, Susana Llanos, Verónica Rodilla, Enrica Soprano, Pablo Pedrosa, Alba Ferreirós, Marta Barradas, Fernanda Hernández-González, Marta Lalinde, Neus Prats, Cristina Bernadó, Patricia González, María Gómez, Maria P. Ikonomopoulou, Pablo J. Fernández-Marcos, Tomás García-Caballero, Pablo del Pino, Joaquín Arribas, Anxo Vidal, Miguel González-Barcia, Manuel Serrano, María I. Loza, Eduardo Domínguez, Manuel Collado
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Senolytic compounds have the ability to eliminate senescent cells from tissues and have been shown to be beneficial in various animal models of age-related diseases. Here the authors show that cardiac glycosides commonly used for heart diseases have
Externí odkaz:
https://doaj.org/article/76f6dda146f1406681b8658e9fa1302e
Autor:
Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-18 (2018)
Abstract Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent
Externí odkaz:
https://doaj.org/article/d67df62499c14123a2c81e830cc433e4
Autor:
Susana Llanos, Juana M. García-Pedrero, Lucia Morgado-Palacin, Juan P. Rodrigo, Manuel Serrano
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The molecular pathways involving p21 and mTORC1 are frequently deregulated in head and neck squamous cell carcinomas (HNSCC). Here, Llanos et al. report a mechanism that regulates p21 stability through the mTORC1/4E-BP1 pathway independently of p53,
Externí odkaz:
https://doaj.org/article/88255eacb3924844babdce1250c9e72f
Autor:
Francisco Triana-Martínez, Pilar Picallos-Rabina, Sabela Da Silva-Álvarez, Federico Pietrocola, Susana Llanos, Verónica Rodilla, Enrica Soprano, Pablo Pedrosa, Alba Ferreirós, Marta Barradas, Fernanda Hernández-González, Marta Lalinde, Neus Prats, Cristina Bernadó, Patricia González, María Gómez, Maria P. Ikonomopoulou, Pablo J. Fernández-Marcos, Tomás García-Caballero, Pablo del Pino, Joaquín Arribas, Anxo Vidal, Miguel González-Barcia, Manuel Serrano, María I. Loza, Eduardo Domínguez, Manuel Collado
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/e54864de02fc4da0b46f0d51b9c32317
Autor:
Lucia Morgado-Palacin, Gianluca Varetti, Susana Llanos, Gonzalo Gómez-López, Dolores Martinez, Manuel Serrano
Publikováno v:
Cell Reports, Vol 13, Iss 4, Pp 712-722 (2015)
Diamond-Blackfan anemia (DBA) is characterized by anemia and cancer susceptibility and is caused by mutations in ribosomal genes, including RPL11. Here, we report that Rpl11-heterozygous mouse embryos are not viable and that Rpl11 homozygous deletion
Externí odkaz:
https://doaj.org/article/956892cb799c4776b9f09c5681ede191
Autor:
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde, Neus Prats, Ines Marin, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fatima Al-Shahrour, Timothy P. Cash, Tamara Tchkonia, James L. Kirkland, Joaquín Arribas, Manuel Serrano
Anti-cancer therapies often result in a subset of surviving cancer cells that undergo therapy-induced senescence (TIS). Senescent cancer cells strongly modify the intratumoural microenvironment favoring immunosuppression and, thereby, tumour growth.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6caa5e5a5f361a54c878bb8bc9505b00
https://doi.org/10.1101/2022.11.04.501681
https://doi.org/10.1101/2022.11.04.501681
Autor:
Susana Llanos, Karun Mutreja, Patricia Ubieto-Capella, Samuel Miguez, Daniel González-Acosta, Juan Méndez, Fernando García, Elena Blanco-Romero, Javier Munoz, Luis Blanco, Massimo Lopes
Publikováno v:
The EMBO Journal
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
DNA interstrand crosslinks (ICLs) induced by endogenous aldehydes or chemotherapeutic agents interfere with essential processes such as replication and transcription. ICL recognition and repair by the Fanconi Anemia pathway require the formation of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a717473159ed5bb2d03523f9e1edcb69
https://doi.org/10.15252/embj.2020106355
https://doi.org/10.15252/embj.2020106355
Publikováno v:
FACSalud, Vol 3, Iss 4, Pp 36-42 (2019)
La relación sexual a una edad temprana y la presencia de un embarazo en adolescentes se ha incrementado significativamente en los últimos años. Esto se asocia con factores sociodemográficos, económicos y culturales. El objetivo de este trabajo d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c6c6b0ede43b96263464dd2980b169
http://ojs.unemi.edu.ec/index.php/facsalud-unemi/article/view/923
http://ojs.unemi.edu.ec/index.php/facsalud-unemi/article/view/923
Autor:
Federico Pietrocola, Manuel Serrano, Miguel Rovira, Elena Hernández-Encinas, Susana Llanos, Diego Megías, Carmen Blanco-Aparicio
Publikováno v:
Oncogene
PubMed Central
PubMed Central
Palbociclib is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) approved for the treatment of some cancers. The main mechanism of action of palbociclib is to induce cell cycle arrest and senescence on responsive cells. Here, we repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50c645341eecabf3473a66aa4a70155
http://europepmc.org/articles/PMC6756094
http://europepmc.org/articles/PMC6756094