Výsledky vyhledávání - "Susana Graciela Afonso"

Experimental Protoporphyria: Effect of bile acids on liver damage induced by griseofulvin

Autor: Maria del Carmen Martinez, Alcira Batlle, Ana Maria Buzaleh, Roberto Meiss, Susana Graciela Afonso, Silvina Fernanda Ruspini

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
BioMed Research International
BioMed Research International, Vol 2015 (2015)

The effect of bile acids administration to an experimental mice model of Protoporphyria produced by griseofulvin (Gris) was investigated. The aim was to assess whether porphyrin excretion could be accelerated by bile acids treatment in an attempt to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f097abdd64e51d935339f62079f9475
https://www.hindawi.com/journals/bmri/2015/436319/

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Protective Action of Antioxidants on Hepatic Damage Induced by Griseofulvin

Autor: M. del C. Martinez, Alcira Batlle, Ana Maria Buzaleh, Susana Graciela Afonso

Publikováno v: The Scientific World Journal, Vol 2014 (2014)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The Scientific World Journal

Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e324d6d70f25f8724f3c9831dc19ea
https://doaj.org/article/a491b8272e3a41edb4fe999ca0db4c1f

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Griseofulvin-induced hepatopathy due to abnormalities in heme pathway

Autor: Ana Maria Buzaleh, Alcira Batlle, Nora M. Navone, César F. Polo, Susana Graciela Afonso, Elba Vazquez

Publikováno v: General Pharmacology: The Vascular System. 29:207-210

1. The effect of long-term griseofulvin (GRIS) topical administration on some indicators of liver damage was examined. 2. Liver porphyrin accumulation was significant; however, no porhyrin crystals were observed under light microscopy. 3. An earlier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dabcb6cc4daa7cb8674364cad5ce2cf
https://doi.org/10.1016/s0306-3623(96)00406-5

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Mechanistic studies on uroporphyrin I-induced photoinactivation of some heme-enzymes

Autor: Susana Graciela Afonso, Alcira Batlle, César F. Polo, Rafael Enríquez de Salamanca

Publikováno v: The International Journal of Biochemistry & Cell Biology. 28:415-420

Aerobic and anaerobic studies have demonstrated that uroporphyrin I-induced inactivation of delta-aminolevulinic acid dehydratase, porphobilinogenase, deaminase and uroporphyrinogen decarboxylase was dependent on oxygen and mediated by reactive oxyge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08069c17fe9eed546a4a73ef514f285e
https://doi.org/10.1016/1357-2725(95)00159-x

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Cytosolic and Mitochondrial Enzymes Inactivation by Uroporphyrin in Light and Darkness

Autor: Rafael Enríquez de Salamanca, Alcira Batlle, Susana Graciela Afonso

Publikováno v: Journal of Enzyme Inhibition. 10:141-146

The effect of uroporphyrin I (UI) on several cytosolic and mitochondrial enzymes (succinyl CoA synthetase, ζ-aminolevulinic acid synthetase, rhodanese, lactate dehydrogenase) has been examined. All the enzymes were inactivated in the presence of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf87a5348432cf448fed33df981db47
https://doi.org/10.3109/14756369609020167

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δ-Aminolevulinic acid dehydratase inactivation by uroporphyrin I in light and darkness

Autor: S. Chinarro, Susana Graciela Afonso, Alcira Batlle, Rafael Enríquez de Salamanca

Publikováno v: International Journal of Biochemistry. 26:255-258

1. 1. The action of uroporphyrin I on erythrocytic ALA-D activity under dark and light conditions was examined. 2. 2. Photo and non-photoinactivation of ALA-D induced by uroporphyrin I were observed. 3. 3. Both effects were dependent on uroporphyrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ad73bb0c01267abc6aabb002afbc93
https://doi.org/10.1016/0020-711x(94)90153-8

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Further Evidence on the Photodynamic and the Novel Non-Photodynamic Inactivation of Uroporphyrinogen Decarboxylase by Uroporphyrin I

Autor: Susana Graciela Afonso, A M del C Batlle, R. E. De Salamanca, S. Chinarro

Publikováno v: Journal of Enzyme Inhibition. 5:225-233

The action of uroporphyrin I (URO I) on the activity of red cell uroporphyrinogen decarboxylase (URO-D) in the dark and under UV light was studied. Light-dependent-and light-independent inactivation was observed. Both effects increased at increasing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3d0f71361cab9fcdd95c3acff907a7
https://doi.org/10.3109/14756369109080061

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In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway

Autor: del Carmen Batlle Alcira Maria, César F. Polo, Ana Maria Buzaleh, Nora M. Navone, Susana Graciela Afonso, Elba Vazquez, Ernesto Schoua

Publikováno v: General Pharmacology: The Vascular System. 21:423-426

1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc001b38c5ac7ba8d1ad59ec2cfdbf10
https://doi.org/10.1016/0306-3623(90)90692-f

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Photodynamic and Non-Photodynamic Action of Several Porphyrins on the Activity of Some Heme-Enzymes

Autor: J. J. Munoz, Susana Graciela Afonso, R. E. De Salamanca, S. Chinarro, Alcira Batlle

Publikováno v: Journal of Enzyme Inhibition. 3:303-310

The action of porphyrins, uroporphyrin I and III (URO I and URO III), pentacarboxylic porphyrin I (PENTA I), coproporphyrin I and III (COPRO I and COPRO III), protoporphyrin IX (PROTO IX) and mesoporphyrin (MESO), on the activity of human erythrocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed81ae8fff75d072ba73f08d7c626092
https://doi.org/10.3109/14756369009030379

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Protoporphyrin IX and oxidative stress

Autor: Susana Graciela Afonso, Gabriela Vanore, Alcira Batlle

Publikováno v: Free radical research. 31(3)

The short- and long-term pro-oxidant effect of protoporphyrin IX (PROTO) administration to mice was studied in liver. A peak of liver porphyrin accumulation was found 2 h after the injection of PROTO (3.5 mg/kg, i.p.); then the amount of porphyrins d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d045995f86858f739c17dc7a71d693d3
https://pubmed.ncbi.nlm.nih.gov/10499772

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