Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Susana, Velasco-Miguel"'
Autor:
Manuel Serrano, Lyubomir T. Vassilev, Daniel Herranz, Susana Velasco-Miguel, Ana Ortega-Molina, Alejo Efeyan
Cellular senescence is emerging as an important in vivo anticancer response elicited by multiple stresses, including currently used chemotherapeutic drugs. Nutlin-3a is a recently discovered small-molecule antagonist of the p53-destabilizing protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36117d56230306414fe5ec0bb534349d
https://doi.org/10.1158/0008-5472.c.6495480.v1
https://doi.org/10.1158/0008-5472.c.6495480.v1
Autor:
Manuel Serrano, Lyubomir T. Vassilev, Daniel Herranz, Susana Velasco-Miguel, Ana Ortega-Molina, Alejo Efeyan
Supplementary Figure 1 from Induction of p53-Dependent Senescence by the MDM2 Antagonist Nutlin-3a in Mouse Cells of Fibroblast Origin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a908a208a7a93c4ed2de14cb3c5c947
https://doi.org/10.1158/0008-5472.22367250.v1
https://doi.org/10.1158/0008-5472.22367250.v1
Autor:
Alberto Martín, Carolina Epifano, Borja Vilaplana-Marti, Iván Hernández, Rocío I. R. Macías, Ángel Martínez-Ramírez, Ana Cerezo, Pablo Cabezas-Sainz, Maria Garranzo-Asensio, Sandra Amarilla-Quintana, Déborah Gómez-Domínguez, Eduardo Caleiras, Jordi Camps, Gonzalo Gómez-López, Marta Gómez de Cedrón, Ana Ramírez de Molina, Rodrigo Barderas, Laura Sánchez, Susana Velasco-Miguel, Ignacio Pérez de Castro
Publikováno v:
Cell death and differentiation.
Despite being frequently observed in cancer cells, chromosomal instability (CIN) and its immediate consequence, aneuploidy, trigger adverse effects on cellular homeostasis that need to be overcome by anti-stress mechanisms. As such, these safeguard r
Autor:
Alexander Nikolayev, Ana Cerezo, Susana Velasco-Miguel, Juan M. Funes, Karim A. Benhadji, Sandaruwan Geeganage, Gloria Martinez-del Hoyo, Frank C. Dorsey, Raymond Gilmour, Henry James Robert, Kenneth D. Roth, Sandra Peregrina, Lillian Sams, Ramón Campos-Olivas, Laura Diezma
Publikováno v:
Cancer Research. 79:2187-2187
Tryptophan metabolism plays a central role in immunosuppression through the local depletion of tryptophan with the concomitant production and accumulation of kynurenine, both of which are immunosuppressive. Indoleamine 2,3-dioxygenase 1 (IDO1), a hem
Publikováno v:
Proceedings of the National Academy of Sciences. 105:9793-9798
The identification of new pharmacological approaches to effectively prevent, treat, and cure the metabolic syndrome is of crucial importance. Excessive exposure to dietary lipids causes inflammatory responses, deranges the homeostasis of cellular met
Autor:
Ana Ortega-Molina, Susana Velasco-Miguel, Alejo Efeyan, Lyubomir T. Vassilev, Daniel Herranz, Manuel Serrano
Publikováno v:
Cancer Research. 67:7350-7357
Cellular senescence is emerging as an important in vivo anticancer response elicited by multiple stresses, including currently used chemotherapeutic drugs. Nutlin-3a is a recently discovered small-molecule antagonist of the p53-destabilizing protein
Publikováno v:
Oncogene. 26:1645-1649
Protein p21Cip1/Waf1 is transcriptionally activated by the tumour suppressor p53 and previous studies have shown that p21 plays a role in tumour suppression. However, the involvement of p21 in p53-mediated tumour suppression remains to be directly de
Autor:
Susana Velasco-Miguel, R. Ilona Linnoila, Andrew D. Patterson, Albert J. Fornace, Robyn T. Philburn, M. Christine Hollander, Errol C. Friedberg
Publikováno v:
Proceedings of the National Academy of Sciences. 102:13200-13205
Chromosome 3p and 1p deletions are among the most frequent genetic changes in human lung cancer and although candidate tumor suppressor genes have been identified in these regions, no causative correlations have been drawn between deletion or mutatio
Autor:
Nicholas E. Geacintov, Zvi Livneh, Susana Velasco-Miguel, Sharon Avkin, Moshe Goldsmith, Errol C. Friedberg
Publikováno v:
Journal of Biological Chemistry. 279:53298-53305
Replication across unrepaired DNA lesions in mammalian cells is effected primarily by specialized, low fidelity DNA polymerases. We studied translesion DNA synthesis (TLS) across a benzo[a]pyrene-guanine (BP-G) adduct, a major mutagenic DNA lesion ge
Autor:
Susana Velasco-Miguel, Errol C. Friedberg, Dorit Nahari, Laurie B. Task, Russell L Daniel, Lisa D. McDaniel
Publikováno v:
DNA Repair. 3:379-386
Mutational hot spots in the human p53 gene are well established in tumors in the human population and are frequently negative prognosticators of the clinical outcome. We previously developed a mouse model of skin cancer with mutations in the xeroderm