Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Susana, Minguet"'
Autor:
Florian Märkl, Christoph Schultheiß, Murtaza Ali, Shih-Shih Chen, Marina Zintchenko, Lukas Egli, Juliane Mietz, Obinna Chijioke, Lisa Paschold, Sebastijan Spajic, Anne Holtermann, Janina Dörr, Sophia Stock, Andreas Zingg, Heinz Läubli, Ignazio Piseddu, David Anz, Marcus Dühren-von Minden, Tianjiao Zhang, Thomas Nerreter, Michael Hudecek, Susana Minguet, Nicholas Chiorazzi, Sebastian Kobold, Mascha Binder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The concept of precision cell therapy targeting tumor-specific mutations is appealing but requires surface-exposed neoepitopes, which is a rarity in cancer. B cell receptors (BCR) of mature lymphoid malignancies are exceptional in that they
Externí odkaz:
https://doaj.org/article/f556d70ecba646069501e54817da7995
Autor:
Nadine M. Woessner, Simon M. Brandl, Sara Hartmann, Wolfgang W. Schamel, Frederike A. Hartl, Susana Minguet
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAntigen binding to the T cell antigen receptor (TCR) leads to the phosphorylation of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3 complex, and thereby to T cell activation. The CD3ε subunit plays a unique role i
Externí odkaz:
https://doaj.org/article/0a1412bd5d8541f29df79e6652127bbd
Autor:
Anna-Maria Schaffer, Gina Jasmin Fiala, Miriam Hils, Eriberto Natali, Lmar Babrak, Laurenz Alexander Herr, Mari Carmen Romero-Mulero, Nina Cabezas-Wallscheid, Marta Rizzi, Enkelejda Miho, Wolfgang WA Schamel, Susana Minguet
Publikováno v:
eLife, Vol 13 (2024)
The ratio between κ and λ light chain (LC)-expressing B cells varies considerably between species. We recently identified Kinase D-interacting substrate of 220 kDa (Kidins220) as an interaction partner of the BCR. In vivo ablation of Kidins220 in B
Externí odkaz:
https://doaj.org/article/8e54cb9af4bb444790bb90fb84a3a4d3
Autor:
Marissa Russ, Anna K. Ehret, Maximilian Hörner, Daniel Peschkov, Rebecca Bohnert, Vincent Idstein, Susana Minguet, Wilfried Weber, Björn F. Lillemeier, O. Sascha Yousefi, Wolfgang W. Schamel
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The kinetics of a ligand-receptor interaction determine the responses of the receptor-expressing cell. One approach to experimentally and reversibly change this kinetics on demand is optogenetics. We have previously developed a system in which the in
Externí odkaz:
https://doaj.org/article/ceac173bb5db4dc798bfa3529829a5dc
Autor:
Matias Ruggieri, Nicolás Ducasa, Claudia Juraske, Virginia Gonzalez Polo, Carolina Berini, Maria Florencia Quiroga, Petros Christopoulos, Susana Minguet, Mirna Biglione, Wolfgang W. Schamel
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The human T-cell leukemia virus type 1 (HTLV-1) is the cause of serious malignant and inflammatory diseases, including adult T-cell leukemia and lymphoma and tropical spastic paraparesis. The potential protective role of γδ T cells in HTLV-1 infect
Externí odkaz:
https://doaj.org/article/d2752eaa270741c99e45cad93c8abdec
Autor:
Katrin Raute, Juliane Strietz, Maria Alejandra Parigiani, Geoffroy Andrieux, Oliver S. Thomas, Klaus M. Kistner, Marina Zintchenko, Peter Aichele, Maike Hofmann, Houjiang Zhou, Wilfried Weber, Melanie Boerries, Mahima Swamy, Jochen Maurer, Susana Minguet
Publikováno v:
Cancer Immunology Research. :OF1-OF20
There are no targeted therapies for patients with triple-negative breast cancer (TNBC). TNBC is enriched in breast cancer stem cells (BCSC), which play a key role in metastasis, chemoresistance, relapse, and mortality. γδ T cells hold great potenti
Autor:
Marlene Langenbach, Sophie Giesler, Stefan Richtsfeld, Sara Costa-Pereira, Lukas Rindlisbacher, Tobias Wertheimer, Lukas M. Braun, Geoffroy Andrieux, Sandra Duquesne, Dietmar Pfeifer, Nadine M. Woessner, Hans D. Menssen, Sanaz Taromi, Justus Duyster, Melanie Börries, Tilman Brummer, Bruce R. Blazar, Susana Minguet, Patrick Turko, Mitchell P. Levesque, Burkhard Becher, Robert Zeiser
Publikováno v:
Molecular Cancer Research. :OF1-OF16
The treatment of patients with metastatic melanoma with immune checkpoint inhibitors (ICI) leads to impressive response rates but primary and secondary resistance to ICI reduces progression-free survival. Novel strategies that interfere with resistan
Autor:
Annika Schultz, Marvin Schnurra, Ali El-Bizri, Nadine M. Woessner, Sara Hartmann, Roland Hartig, Susana Minguet, Burkhart Schraven, Luca Simeoni
Publikováno v:
Cells, Vol 11, Iss 17, p 2723 (2022)
Alterations in both the expression and function of the non-receptor tyrosine kinase Zap70 are associated with numerous human diseases including immunodeficiency, autoimmunity, and leukemia. Zap70 propagates the TCR signal by phosphorylating two impor
Externí odkaz:
https://doaj.org/article/db624c48de2e40a6a9e7b62f90a02226
Autor:
Anh Thu Dang, Juliane Strietz, Alessandro Zenobi, Hanif J. Khameneh, Simon M. Brandl, Laura Lozza, Gregor Conradt, Stefan H.E. Kaufmann, Walter Reith, Ivo Kwee, Susana Minguet, Sonia T. Chelbi, Greta Guarda
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101900- (2021)
Summary: BTN3A molecules—BTN3A1 in particular—emerged as important mediators of Vγ9Vδ2 T cell activation by phosphoantigens. These metabolites can originate from infections, e.g. with Mycobacterium tuberculosis, or by alterations in cellular me
Externí odkaz:
https://doaj.org/article/de729f8b994f4debb0363e2537507785
Autor:
Susana Minguet, Jochen Maurer, Mahima Swamy, Melanie Boerries, Wilfried Weber, Houjiang Zhou, Maike Hofmann, Peter Aichele, Marina Zintchenko, Klaus M. Kistner, Oliver S. Thomas, Geoffroy Andrieux, Maria Alejandra Parigiani, Juliane Strietz, Katrin Raute
Supplementary Video S1 UT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c266542d20b9653517c320c8a2e73ca
https://doi.org/10.1158/2326-6066.22758530.v1
https://doi.org/10.1158/2326-6066.22758530.v1