Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Susan Winks"'
Publikováno v:
ACS Infectious Diseases. 9:389-393
Publikováno v:
Nature medicine. 28(8)
Autor:
Biljana Marjanovic-Painter, Molahlehi S. Sonopo, Susan Winks, Kobus Venter, Garreth L. Morgans, Jan Rijn Zeevaart
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:264-269
This paper describes a five-step synthesis of a carbon-14-labelled pyrazole compound (11). A total of 2.96 MBq of 11 was obtained with the specific activity of 2242.4 MBq/mmol. The radiochemical purity was >99%, and the overall radiochemical yield wa
Autor:
Molahlehi S. Sonopo, Biljana Marjanovic-Painter, Susan Winks, Grant A. Boyle, Jan Rijn Zeevaart, Kobus Venter
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 58:23-29
A potential anti-TB compound bearing a nitroimidazole moiety from iThemba Pharmaceuticals TB chemical library exhibits promising in vitro activity in the microplate almar blue assay (MABA) with a minimum inhibitory concentration (MIC) value of 3 µg/
Autor:
Philip Richards, Ellen Ngarande, Roger Hunter, Kani Zilbeyaz, Thozama Ogunleye, Jonathan Cotton, Yabing Wang, Vuyolwethu Siyo, Catherine H. Kaschula, Mino R. Caira, Nashia Stellenboom, Susan Winks, M. Iqbal Parker
Publikováno v:
European Journal of Medicinal Chemistry. 50:236-254
The organosulfur compound ajoene derived from the rearrangement of allicin found in crushed garlic can inhibit the proliferation of tumour cells by inducing G(2)/M cell cycle arrest and apoptosis. We report on the application of a concise four-step s
Autor:
Candice Soares de Melo, Renier van der Westhuyzen, Ujjini H. Manjunatha, Luca Arista, Atica Moosa, Grant A. Boyle, Leslie J. Street, Nina Lawrence, Christel Brunschwig, Frederick A. Sirgel, Richard K. Gessner, Paul W. Smith, Colin R. Wilson, Paul D. van Helden, Mathew Njoroge, Dale Taylor, Ronnett Seldon, Kelly Chibale, Srinivasa P. S. Rao, Carmen de Kock, Digby F. Warner, Susan Winks
Publikováno v:
Journal of medicinal chemistry. 58(23)
High-throughput screening of a library of small polar molecules against Mycobacterium tuberculosis led to the identification of a phthalimide-containing ester hit compound (1), which was optimized for metabolic stability by replacing the ester moiety
Autor:
Molahlehi S, Sonopo, Kobus, Venter, Susan, Winks, Biljana, Marjanovic-Painter, Garreth L, Morgans, Jan R, Zeevaart
Publikováno v:
Journal of labelled compoundsradiopharmaceuticals. 59(7)
This paper describes a five-step synthesis of a carbon-14-labelled pyrazole compound (11). A total of 2.96 MBq of 11 was obtained with the specific activity of 2242.4 MBq/mmol. The radiochemical purity was99%, and the overall radiochemical yield was
Autor:
Molahlehi S, Sonopo, Kobus, Venter, Grant, Boyle, Susan, Winks, Biljana, Marjanovic-Painter, Jan R, Zeevaart
Publikováno v:
Journal of labelled compoundsradiopharmaceuticals. 58(2)
A potential anti-TB compound bearing a nitroimidazole moiety from iThemba Pharmaceuticals TB chemical library exhibits promising in vitro activity in the microplate almar blue assay (MABA) with a minimum inhibitory concentration (MIC) value of 3 µg/
Autor:
Sergio Wittlin, David Waterson, Christopher David Edlin, Susan Winks, Jeremy N. Burrows, Garreth L. Morgans, Sandra Duffy, Vicky M. Avery, Justin S. Bryans
Publikováno v:
ACS medicinal chemistry letters. 3(7)
Triage of a set of antimalaria hit compounds, identified through high throughput screening against the Chloroquine sensitive (3D7) and resistant (Dd2) parasite Plasmodium falciparum strains identified several novel chemotypes suitable for hit-to-lead
Publikováno v:
Acta crystallographica. Section C, Crystal structure communications. 65(Pt 11)
The title compound, C(7)H(13)NO, forms R(2)(2)(8) N-H...O hydrogen-bonded dimers and C4 N-H...O-linked chains, which are further stabilized by a C-H...O interaction. The combination of these interactions results in a hydrogen-bonded network parallel