Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Susan Winandy"'
Autor:
Martin Peter Steinbuck, Susan Winandy
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The Notch receptor is an evolutionarily highly conserved transmembrane protein essential to a wide spectrum of cellular systems, and its deregulation has been linked to a vast number of developmental disorders and malignancies. Regulated Notch functi
Externí odkaz:
https://doaj.org/article/56271fbc69cb4c95a9cd56bc94ce9ef8
Publikováno v:
The Journal of Immunology. 202:1112-1123
CD4 Th cells are organizers of the immune response, directing other immune cells to initiate and maintain effective humoral and cellular immunity. CD4 T cells differentiate into distinct Th effector or regulatory subsets in response to signals delive
Publikováno v:
Immunology. 152:494-506
Ikaros is a transcription factor that regulates lymphocyte development from the level of the haematopoietic stem cell. Lack of Ikaros reduces the ability of progenitor cells to commit to the T‐cell lineage, resulting in reduced numbers of early thy
Autor:
Susan Winandy, Martin Peter Steinbuck
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The Notch receptor is an evolutionarily highly conserved transmembrane protein essential to a wide spectrum of cellular systems, and its deregulation has been linked to a vast number of developmental disorders and malignancies. Regulated Notch functi
Autor:
Susan Winandy
Publikováno v:
European Journal of Immunology. 43:314-317
Ikaros is a transcriptional regulator critical for B- and T-cell development. Recently, it has been shown to play a central role in facilitating rearrangement of antigen-receptor genes in B cells. Whether or not it had a similar function in this proc
Autor:
Peter Chockley, Susan Winandy, Isao Tawara, Pavan Reddy, Ann Friedman, Rebecca Evers, Chelsea Malter, Evelyn Nieves, Chen Liu, Yaping Sun, Tomomi Toubai, Ivan Maillard
Publikováno v:
Blood. 118:192-204
Host hematopoietically derived APCs play a vital role in the initiation of GVH responses. However, the APC autonomous molecular mechanisms that are critical for the induction of GVHD are not known. We report here that the Ikaros-Notch axis in host he
Publikováno v:
The Journal of Immunology. 185:410-417
Ikaros and Notch are transcriptional regulators essential for normal T cell development. Aberrant activation of Notch target genes is observed in Ikaros-deficient thymocytes as well as leukemia cell lines. However, it is not known whether Notch dereg
Autor:
Susan Winandy, Sarah E. Umetsu
Publikováno v:
The Journal of Immunology. 183:5518-5525
IL-10 is a regulatory cytokine critical for controlling inflammatory responses. Here we show that Ikaros, a zinc finger DNA-binding protein, plays an important role in the regulation of Il10 in murine CD4+ T cells. Upon initial stimulation of the TCR
Publikováno v:
The Journal of Immunology. 182:3955-3959
Positive selection is a critical T cell developmental checkpoint that is driven by TCR signals. Enhanced positive selection toward the CD4 lineage occurs in the absence of Ikaros. One explanation for this phenotype is that Ikaros establishes the TCR
Publikováno v:
The Journal of Immunology. 182:741-745
Ikaros, a hematopoietic transcription factor, has well defined effects on early lymphocyte development in the bone marrow and thymus. In this study we demonstrate that Ikaros is a positive regulator of Th2 cytokine gene expression in peripheral T cel