Impact of benzalkonium chloride-preserved and preservative-free latanoprost eye drops on cultured human conjunctival goblet cells upon acute exposure and differences in physicochemical properties of the eye drops

Autor: Steffen Heegaard, Anne Hedengran, Miriam Kolko, Tor P Utheim, Darlene A Dartt, Goran Petrovski, Olivia Müllertz, Zaynab Ahmad Mouhammad, Josefine Freiberg, Richárd Nagymihály, Jette Jacobsen, Susan Weng Larsen, Jeffrey Bair

Publikováno v: BMJ Open Ophthalmology, Vol 6, Iss 1 (2021)

Objective To investigate the short-term impact on human conjunctival goblet cell (GC) survival and mucin release of acute exposure to benzalkonium chloride (BAK) preserved and preservative-free (PF) 0.005% (w/v) latanoprost (LT) eye drops, and to com

Externí odkaz: https://doaj.org/article/2731e9f64c1545518e8457f28a8aeb5f

Generic benzalkonium chloride-preserved travoprost eye drops are not identical to the branded polyquarternium-1-preserved travoprost eye drop: Effect on cultured human conjunctival goblet cells and their physicochemical properties

Autor: Anne Hedengran, Josefine Clement Freiberg, Pernille May Hansen, Jette Jacobsen, Susan Weng Larsen, Stine Harloff‐Helleberg, Kristine Freude, Gerard Boix‐Lemonche, Goran Petrovski, Steffen Heegaard, Miriam Kolko

Publikováno v: Hedengran, A, Freiberg, J C, Hansen, P M, Jacobsen, J, Larsen, S W, Harloff-helleberg, S, Freude, K, Boix-lemonche, G, Petrovski, G, Heegaard, S & Kolko, M 2022, ' Generic benzalkonium chloride-preserved travoprost eye drops are not identical to the branded polyquarternium-1-preserved travoprost eye drop : Effect on cultured human conjunctival goblet cells and their physicochemical properties ', Acta Ophthalmologica, vol. 100, no. 7, pp. 819-827 . https://doi.org/10.1111/aos.15163

PurposeTo investigate the effect of polyquaternium-1 (PQ)-preserved and benzalkonium chloride (BAK)-preserved travoprost eye drops on viability of primary human conjunctival goblet cell (GC) cultures and on secretion of mucin and cytokines. Furthermo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0a4c27f499aa3ab7df49f36de52e4d
https://pubmed.ncbi.nlm.nih.gov/35527390

Diclofenac Prodrugs for Intra-articular Depot Injectables: In Vitro Hydrolysis and Species Variation

Autor: Nina Mertz, Susan Weng Larsen, Jesper Østergaard, Jesper L. Kristensen, Claus Larsen, Ida Hagen Storgaard

Publikováno v: Journal of Pharmaceutical Sciences. 109:1529-1536

Intra-articular depot injectables based on in situ suspension formation of ester prodrugs of nonsteroidal anti-inflammatory drugs are promising for management of joint pain. As candidates for this delivery approach, 5 diclofenac ester prodrugs compri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95570000cda9d51915372e5200bd857
https://doi.org/10.1016/j.xphs.2020.01.003

An in vitro gel-based system for characterizing and predicting the long-term performance of PLGA in situ forming implants

Autor: Jesper Østergaard, Henrik Jensen, Zhuoxuan Li, Susan Weng Larsen, Huiling Mu

Publikováno v: Li, Z, Mu, H, Weng Larsen, S, Jensen, H & Østergaard, J 2021, ' An in vitro gel-based system for characterizing and predicting the long-term performance of PLGA in situ forming implants ', International Journal of Pharmaceutics, vol. 609, 121183 . https://doi.org/10.1016/j.ijpharm.2021.121183

In situ forming implants are exposed to an extracellular matrix resembling a gel rather than aqueous solution upon subcutaneous administration. The aim of study was to develop a gel-based release testing system for characterizing the long-term in vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2104e39280304e7778895c1702802c4
https://curis.ku.dk/portal/da/publications/an-in-vitro-gelbased-system-for-characterizing-and-predicting-the-longterm-performance-of-plga-in-situ-forming-implants(7ac748db-2520-4556-9c53-58ad41ebcc11).html

In situ monitoring of the formation of lipidic non-lamellar liquid crystalline depot formulations in synovial fluid

Autor: Mechthild Schmitt, Anne Louise Uldall Jonassen, Michael Rappolt, Anan Yaghmur, Susan Weng Larsen

Publikováno v: Journal of colloid and interface science. 582

Administration of parenteral liquid crystalline phases, forming in-vivo with tunable nanostructural features and sustained release properties, offers an attractive approach for treatment of infections and local drug delivery. It has also a potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d0117ee2714561d22cf42ec37d30cf
https://pubmed.ncbi.nlm.nih.gov/32916575