Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Susan W. Farmer"'
Autor:
Arjun Baghela, Olga M. Pena, Amy H. Lee, Beverlie Baquir, Reza Falsafi, Andy An, Susan W. Farmer, Andrew Hurlburt, Alvaro Mondragon-Cardona, Juan Diego Rivera, Andrew Baker, Uriel Trahtemberg, Maryam Shojaei, Carlos Eduardo Jimenez-Canizales, Claudia C. dos Santos, Benjamin Tang, Hjalmar R. Bouma, Gabriela V. Cohen Freue, Robert E.W. Hancock
Publikováno v:
EBioMedicine
EBioMedicine, 75:103776. ELSEVIER SCIENCE BV
EBioMedicine, 75:103776. ELSEVIER SCIENCE BV
Background Inter-individual variability during sepsis limits appropriate triage of patients. Identifying, at first clini-cal presentation, gene expression signatures that predict subsequent severity will allow clinicians to identify the most at-risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ecc37ac04e9d844252f4264d2b1680e
https://doi.org/10.1016/j.ebiom.2021.103776
https://doi.org/10.1016/j.ebiom.2021.103776
Autor:
Jason Kindrachuk, Sandy Hsiang Yu Chiang, Rudolf Volkmer, Lindsay L. Weaver, Melissa Elliott, Nelly Panté, Dirk F. H. Winkler, Susan W. Farmer, Kai Hilpert, Jana Körner, Håvard Jenssen, Anne S. Ulrich, Robert E. W. Hancock, Peter Henklein, Christopher D. Fjell
Publikováno v:
Chemistry & Biology; Vol 16
SummaryThere is an urgent need to coat the surfaces of medical devices, including implants, with antimicrobial agents to reduce the risk of infection. A peptide array technology was modified to permit the screening of short peptides for antimicrobial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf39896cf11138006dc01937b3c5054
Autor:
Colin T. Mant, Susan W. Farmer, Robert E. W. Hancock, Robert S. Hodges, Yuxin Chen, Michael L. Vasil
Publikováno v:
Journal of Biological Chemistry. 280:12316-12329
In the present study, the 26-residue peptide sequence Ac-KWKSFLKTFKSAVKTVLHTALKAISS-amide (V681) was utilized as the framework to study the effects of peptide hydrophobicity/hydrophilicity, amphipathicity, and helicity (induced by single amino acid s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db75f1124702eeb586d46983b967f9db
https://doi.org/10.1074/jbc.m413406200
https://doi.org/10.1074/jbc.m413406200
Publikováno v:
The Journal of Peptide Research. 60:198-214
Indolizidin-2-one amino acids (I2aas, 6S- and 6R-1) possessing 6S- and 6R-ring-fusion stereochemistry were introduced into the antimicrobial peptide gramicidin S (GS) to explore the relationships between configuration, peptide conformation and biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::267e6f47f8c03e1d3d7ce4cedc71cf20
https://doi.org/10.1034/j.1399-3011.2002.21026.x
https://doi.org/10.1034/j.1399-3011.2002.21026.x
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:3317-3321
Polymyxins B and E1 and gramicidin S are bacterium-derived cationic antimicrobial peptides. The polymyxins were more potent than gramicidin S against Pseudomonas aeruginosa, with MICs of 0.125 to 0.25 and 8 mg/ml, respectively. These peptides differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da75aaf2394c042049d76e7c56b58cd
https://doi.org/10.1128/aac.44.12.3317-3321.2000
https://doi.org/10.1128/aac.44.12.3317-3321.2000
Autor:
Robert E. W. Hancock, Cyril M. Kay, Susan W. Farmer, Robert S. Hodges, Leslie H. Kondejewski, David S. Wishart
Publikováno v:
Journal of Biological Chemistry. 271:25261-25268
We have evaluated the effect of ring size of gramicidin S analogs on secondary structure, lipid binding, lipid disruption, antibacterial and hemolytic activity. Cyclic analogs with ring sizes ranging from 4 to 14 residues were designed to maintain th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f18695f2d739eee786334a50ff8961
https://doi.org/10.1074/jbc.271.41.25261
https://doi.org/10.1074/jbc.271.41.25261
Publikováno v:
Phytochemical Analysis. 6:125-129
An improved bioautographic agar overlay method was developed for the detection of antimicrobial compounds from crude plant extracts using phenol red and a tetrazolium compound as dyes to improve resolution. This method worked successfully with a wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c8b54ad4523b66ae0b212b2094e20d6
https://doi.org/10.1002/pca.2800060303
https://doi.org/10.1002/pca.2800060303
Publikováno v:
International Journal of Pharmacognosy. 33:33-36
The methanol extract of the bark of Alnus rubra showed antimicrobial activity against Gram-positive and Gram-negative bacteria. Diarylheptanoid and its glycoside (oregonin) were identified as the two constituents responsible for this activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42a39c7576fd919735a04bd23103d96b
https://doi.org/10.3109/13880209509088144
https://doi.org/10.3109/13880209509088144
Publikováno v:
Journal of Ethnopharmacology. 42:95-99
The antimicrobial activity of the methanol extract and isolated constituents of Rhus glabra (Anacardiaceae), a species used in folk medicine by North American native people, was evaluated against 11 microorganisms, including gram-positive and gram-ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39918ffd942fc06f6245cdcbf8ca3d1
https://doi.org/10.1016/0378-8741(94)90102-3
https://doi.org/10.1016/0378-8741(94)90102-3
Autor:
Robert E. W. Hancock, Susan W. Farmer
Publikováno v:
Antimicrobial Agents and Chemotherapy. 37:453-456
Teicoplanin is a glycopeptide antibiotic which is ineffective against gram-negative bacteria because of its inability to penetrate the outer membrane. Removal of the sugar residues and attachment of polyamines to carbon 63 yielded two dibasic degluco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526eadc0280b409d93f7c96f64535970
https://doi.org/10.1128/aac.37.3.453
https://doi.org/10.1128/aac.37.3.453