Výsledky vyhledávání - "Susan W J Janssen"

Akademický článek

Non-Publication Is Common among Phase 1, Single-Center, Not Prospectively Registered, or Early Terminated Clinical Drug Trials.

Autor: Cornelis A van den Bogert, Patrick C Souverein, Cecile T M Brekelmans, Susan W J Janssen, Gerard H Koëter, Hubert G M Leufkens, Lex M Bouter

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167709 (2016)

The objective of this study was to investigate the occurrence and determinants of non-publication of clinical drug trials in the Netherlands.All clinical drug trials reviewed by the 28 Institutional Review Boards (IRBs) in the Netherlands in 2007 wer

Externí odkaz: https://doaj.org/article/c3f181797aa2418dbc42edeef9e74b5c

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Implementation of Pharmacogenetics in Primary Care: A Multi-Stakeholder Perspective

Autor: Marleen E. Jansen, Jordy M de Groot, Wendy Rodenburg, Martina C. Cornel, Susan W J Janssen, Tessel Rigter

Publikováno v: Frontiers in Genetics, 11:10. Frontiers Media S.A.
Frontiers in Genetics, Vol 11 (2020)
Frontiers in Genetics
Rigter, T, Jansen, M E, Groot, J M D, Janssen, S W J, Rodenburg, W & Cornel, M C 2020, ' Implementation of Pharmacogenetics in Primary Care : A Multi-Stakeholder Perspective ', Frontiers in Genetics, vol. 11, 10 . https://doi.org/10.3389/fgene.2020.00010, https://doi.org/10.3389/fgene.2020.00010
Frontiers in genetics, 11:10. Frontiers Media S.A.

Introduction: Aberrant pharmacogenetic variants occur in a high proportion of people and might be relevant for the prescription of over 26 drugs in primary care. Early identification of patients who metabolize these drugs more rapidly or slowly than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4e27e2b86b7c6cff2d31de96faabd5
https://research.vumc.nl/en/publications/6533449b-eeb4-43dc-b13d-cfcfa6a8acfd

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Metabolic profile of the hippocampus of Zucker Diabetic Fatty rats assessed by in vivo 1H magnetic resonance spectroscopy

Autor: Marinette van der Graaf, Arend Heerschap, Jack J.A. van Asten, Gerard J.M. Martens, Jeroen A. Pikkemaat, C.G.J. Sweep, Ad R. M. M. Hermus, Susan W. J. Janssen

Publikováno v: NMR in Biomedicine, 17, 6, pp. 405-10
NMR in Biomedicine, 17, 405-10

Contains fulltext : 57305.pdf (Publisher’s version ) (Closed access) Localized in vivo 1H magnetic resonance spectroscopy (MRS) was used to investigate metabolite levels in the brain of adult Zucker Diabetic Fatty (ZDF) rats, an animal model for ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61c40750a79f72de1f72da124c1c124
https://doi.org/10.1002/nbm.896

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Expression of the Novel Epithelial Ca2+Channel ECaC1 in Rat Pancreatic Islets

Autor: Joost G. J. Hoenderop, René J. M. Bindels, Gerard J.M. Martens, Fred C.G.J. Sweep, Ad R. M. M. Hermus, Susan W. J. Janssen

Publikováno v: Journal of Histochemistry and Cytochemistry, 50, 6, pp. 789-798
Journal of Histochemistry and Cytochemistry, 50, 789-798
Journal of Histochemistry and Cytochemistry, 50, 789-98
Journal of Histochemistry and Cytochemistry, 50, 6, pp. 789-98

The epithelial Ca2+channel, ECaC1, is primarily expressed in the apical membrane of vitamin D-responsive tissues. This study characterizes for the first time the presence of this novel channel in pancreatic tissue by reverse transcriptase-polymerase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e90b206d4a6d7bb7e05ec60dad9e3bc
https://doi.org/10.1177/002215540205000605

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Phlorizin treatment prevents the decrease in plasma insulin levels but not the progressive histopathological changes in the pancreatic islets during aging of Zucker diabetic fatty rats

Autor: Albert A.J. Verhofstad, Gerard J.M. Martens, Paul N. Span, C.G.J. Sweep, A. R. M. M. Hermus, Susan W. J. Janssen

Publikováno v: Journal of Endocrinological Investigation, 26, 508-15
Journal of Endocrinological Investigation, 26, 6, pp. 508-15

Contains fulltext : 142092.pdf (Publisher’s version ) (Closed access) A hallmark of Type 2 diabetes mellitus (T2DM) is chronic hyperglycemia, which is thought to play a role in pancreatic beta-cell failure. Here we investigated whether treatment of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6508b989896cd4a9c52c28eca1e700
https://pubmed.ncbi.nlm.nih.gov/12952363

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Exploring levels of hexosamine biosynthesis pathway intermediates and protein kinase C isoforms in muscle and fat tissue of Zucker Diabetic Fatty rats

Autor: Sjenet E. van Emst-de Vries, Paul N. Span, Gerard J.M. Martens, C.G.J. Sweep, Susan W. J. Janssen, Ad R. M. M. Hermus, André J. Olthaar, Remko R. Bosch, Peter H.G.M. Willems

Publikováno v: Endocrine, 20, 247-52
Endocrine, 20, 3, pp. 247-52

Item does not contain fulltext Many studies suggest that insulin resistance develops and/or is maintained by an increased flux of glucose through the hexosamine biosynthesis pathway. This pathway may attenuate insulin-stimulated glucose uptake by act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ec4280803946075b16d5769264eb62
http://hdl.handle.net/2066/143684

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Outcomes of EMA marketing authorization applications: does partnering have an influence?

Autor: Susan W. J. Janssen, Michelle Putzeist, Hubert G. M. Leufkens, Cornelis A. van den Bogert, Patrick C. Souverein, Gerard H. Koëter

Publikováno v: Nature Reviews Drug Discovery. 13:878-878

Regulatory watch: Outcomes of EMA marketing authorization applications: does partnering have an influence?

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be8bb9a1c3b83ae0ca084e8a2ec74609
https://doi.org/10.1038/nrd4468

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Progressive histopathological changes in pancreatic islets of Zucker Diabetic Fatty rats

Autor: Q. Knijnenburg, Ad R. M. M. Hermus, C. G. J. F. Sweep, Albert A.J. Verhofstad, Susan W. J. Janssen, Gerard J.M. Martens, J. A. W. M. van der Laak, W. Lange

Publikováno v: Experimental and Clinical Endocrinology & Diabetes, 109, 5, pp. 273--82
Experimental and Clinical Endocrinology & Diabetes, 109, 273--82

Contains fulltext : 144692.pdf (Publisher’s version ) (Open Access) Thus far, histopathological changes in the pancreatic islets of Zucker Diabetic Fatty (ZDF) rats, an animal model of type 2 diabetes mellitus (or non-insulin-dependent diabetes mel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673d52f2a401923b146316e85a5a90b6
https://pubmed.ncbi.nlm.nih.gov/11507651

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