Zobrazeno 1 - 10 of 40 pro vyhledávání: '"Susan W, Robinson"'
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Akademický článek
Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.
Autor: Susan W Robinson, Julie-Myrtille Bourgognon, Jereme G Spiers, Carlo Breda, Susanna Campesan, Adrian Butcher, Giovanna R Mallucci, David Dinsdale, Nobuhiro Morone, Raj Mistry, Tim M Smith, Maria Guerra-Martin, R A John Challiss, Flaviano Giorgini, Joern R Steinert
Publikováno v: PLoS Biology, Vol 16, Iss 4, p e2003611 (2018)
Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation. Importantl
Externí odkaz: https://doaj.org/article/9e9cf68bba724e81a075808600ab4057
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2
Kv3.1 and Kv3.3 subunits differentially contribute to Kv3 channels and action potential repolarization in principal neurons of the auditory brainstem
Autor: Victoria Ciampani, Nasreen Choudhury, Michelle Anderson, Ian D. Forsythe, Sophie M. Walter, Conny Kopp-Scheinpflug, Susan W. Robinson, Deborah M. Linley, Joern R. Steinert, Vincenzo Marra, Amy Richardson
Publikováno v: The Journal of Physiology. 598:2199-2222
Kv3.1 and Kv3.3 subunits are highly expressed in the auditory brainstem, with little or no mRNA for Kv3.2 or Kv3.4. Changes in Kv3 currents and action potential (AP) firing were analysed from wild-type, Kv3.1 and Kv3.3 knockout (KO) mice. Both Kv3.1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb33bff9fa052d9af775b565ded1e80
https://doi.org/10.1113/jp279668
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3
Complex response to physiological and drug-induced hepatic heme demand in monoallelic ALAS1 mice
Autor: Andrew G. Smith, Tatyana Chernova, Viktoria Vágány, Susan W. Robinson
Publikováno v: Molecular Genetics and Metabolism Reports, Vol 29, Iss, Pp 100818-(2021)
Regulation of 5-aminolevulinate synthase 1 (ALAS1) for nonerythroid heme is critical for respiration, cell signaling mechanisms and steroid/drug metabolism. ALAS1 is induced in some genetic disorders but unlike other genes in the heme pathway, a gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1defd254f2fc2f69666e006ed754791
http://www.sciencedirect.com/science/article/pii/S2214426921001130
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4
Inhibition of neuroinflammatory nitric oxide signalling supresses protein glycation and recovers neuronal dysfunction in prion disease
Autor: Jereme G. Spiers, Andrew B. Tobin, Catharine A. Ortori, Susan W. Robinson, Joern R. Steinert, Sophie J. Bradley, Julie-Myrtille Bourgognon, Hannah Scheiblich
Background: Several neurodegenerative diseases associated with protein misfolding (Alzheimer’s, Parkinson’s disease) exhibit oxidative and nitrergic stress following initiation of neuroinflammatory pathways. Associated nitric oxide (NO)-mediated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7370e1c3b67a691a7d5a3403484a3a1a
https://doi.org/10.21203/rs.3.rs-20075/v1
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5
Drosophila Nrf2/Keap1 Mediated Redox Signaling Supports Synaptic Function and Longevity and Impacts on Circadian Activity
Autor: Jereme G. Spiers, Joern R. Steinert, Carlo Breda, Susan W. Robinson, Flaviano Giorgini
Publikováno v: Frontiers in Molecular Neuroscience, Vol 12 (2019)
Frontiers in Molecular Neuroscience
Many neurodegenerative conditions and age-related neuropathologies are associated with increased levels of reactive oxygen species (ROS). The cap “n” collar (CncC) family of transcription factors is one of the major cellular system that fights ox
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e97600dc4fb5923e28d01d1ace7b159
https://doi.org/10.3389/fnmol.2019.00086
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7
The Sound of Silence: Ionic Mechanisms Encoding Sound Termination
Autor: Cornelia Kopp-Scheinpflug, Ian D. Forsythe, Adam Tozer, Bruce L. Tempel, Susan W. Robinson, Matthias H. Hennig
Publikováno v: Neuron. 71(5):911-925
Summary Offset responses upon termination of a stimulus are crucial for perceptual grouping and gap detection. These gaps are key features of vocal communication, but an ionic mechanism capable of generating fast offsets from auditory stimuli has pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddc0c9b2ce64aa0f954e86a1b2c4190
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8
Nitric Oxide Is an Activity-Dependent Regulator of Target Neuron Intrinsic Excitability
Autor: Martin D. Haustein, Ian D. Forsythe, Cornelia Kopp-Scheinpflug, Susan W. Robinson, Huaxia Tong, Joern R. Steinert
Publikováno v: Neuron
Summary Activity-dependent changes in synaptic strength are well established as mediating long-term plasticity underlying learning and memory, but modulation of target neuron excitability could complement changes in synaptic strength and regulate net
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf731049e33f66b08a8c925d7796895c
http://europepmc.org/articles/PMC3245892
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9
Regulation of Kv channel expression and neuronal excitability in rat medial nucleus of the trapezoid body maintained in organotypic culture
Autor: Tatyana Chernova, Susan W. Robinson, Ian D. Forsythe, Huaxia Tong, Douglas L. Oliver, David J. Read, Joern R. Steinert
Publikováno v: The Journal of Physiology. 588:1451-1468
Principal neurons of the medial nucleus of the trapezoid body (MNTB) express a spectrum of voltage-dependent K(+) conductances mediated by Kv1-Kv4 channels, which shape action potential (AP) firing and regulate intrinsic excitability. Postsynaptic fa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2e1cea0afc5e73d3571e5a29ac0af14
https://doi.org/10.1113/jphysiol.2009.186676
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10
NMDAR-mediated EPSCs are maintained and accelerate in time course during maturation of mouse and rat auditory brainstemin vitro
Autor: Melissa D. Jordan, Ian D. Forsythe, Tatyana Chernova, Michael Postlethwaite, Susan W. Robinson, Joern R. Steinert
Publikováno v: The Journal of Physiology. 588:447-463
NMDA receptors (NMDARs) mediate a slow EPSC at excitatory glutamatergic synapses throughout the brain. In many areas the magnitude of the NMDAR-mediated EPSC declines with development and is associated with changes in subunit composition, but the mat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7154c94c739e3778f3281828cbbb58e9
https://doi.org/10.1113/jphysiol.2009.184317
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