Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Susan V. Hughes"'
Autor:
Cedric H. L. Shackleton, Susan V. Hughes, Beverly A. Hughes, Peter Nightingale, Paul M. Stewart, Nicola Crabtree, Theresa McCarthy, Rachel K Crowley, Joanna Gray, Jeremy W. Tomlinson
Publikováno v:
Europe PubMed Central
ObjectiveDysregulation of enzymes that control local tissue steroid metabolism has been implicated in the pathogenesis of obesity and insulin resistance; however, longitudinal changes in glucocorticoid metabolism have not been investigated. This stud
Autor:
Susan V. Hughes, William Carley, Fiona Kilvington, Jeremy W. Tomlinson, Beverley Hughes, Paul M. Stewart, Rachel Courtney, William A. Bartlett, Mark Sherlock, Paul A. Rejto
Publikováno v:
J Clin Endocrinol Metab
Context: The pathophysiological importance of glucocorticoids (GCs) is exemplified by patients with Cushing’s syndrome who develop hypertension, obesity, and insulin resistance. At a cellular level, availability of GCs to the glucocorticoid and min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07320cd431347a430e3e3462e8255f7
https://ora.ox.ac.uk/objects/uuid:8af5a540-4c6f-459f-b8e0-c250aadde678
https://ora.ox.ac.uk/objects/uuid:8af5a540-4c6f-459f-b8e0-c250aadde678
Autor:
Paul Cockwell, Neil T. Raymond, Susan V. Hughes, Alexander J. Howie, Daniel Zehnder, Julia Lepenies, Paul M. Stewart, Marcus Quinkler, Rosemary Bland, Kevin S. Eardley, Martin Hewison
Publikováno v:
Kidney International. 74:1343-1353
To examine any potential role for 1,25-dihydroxyvitamin D (1,25(OH)2D) in inflammation associated with chronic kidney disease we measured vitamin D metabolites, markers of inflammation and gene expression in 174 patients with a variety of kidney dise
Publikováno v:
Diabetes
OBJECTIVE—The epidemics of obesity, insulin resistance, and type 2 diabetes have heightened the need to understand mechanisms that contribute to their pathogenesis. Increased endogenous glucocorticoid production has been implicated based on paralle
Autor:
Lisa Blackwell, Daniel Zehnder, Colin Baigent, John N. Townend, William D. Fraser, Charles J. Ferro, David C. Wheeler, S. L. Nuttall, Martin J Landray, Susan V. Hughes, Martin Hewison
Publikováno v:
Nephron Clinical Practice. 107:c109-c116
Background: Disturbances in mineral and vitamin D metabolism, which affect parathyroid hormone (PTH) synthesis, are well recognized in patients receiving dialysis. However, it is unclear at what stage of chronic kidney disease (CKD) these abnormaliti
Autor:
Paul M. Stewart, Marcus Quinkler, Sabine Buhner, Susan V. Hughes, Martin Hewison, Bruno Allolio, Kirren Kaur, Iwona J. Bujalska, Claire Onyimba
Publikováno v:
Hypertension. 46:787-798
Rodents studies suggest that androgens are involved in sex-specific differences in blood pressure. In humans, there is no difference in blood pressure between boys and girls, but after puberty, blood pressure increases more in men than in women. We i
Autor:
Lisa M. Freeman, Ronjon Chakraverty, Katie N. Evans, Susan V. Hughes, Deborah Hardie, Terry K. Means, Martin Hewison
Publikováno v:
Blood. 106:2042-2049
Glucocorticoids (GCs) exert powerful anti-inflammatory effects that may relate in part to their ability to restrict the differentiation and function of dendritic cells (DCs). Although these inhibitory effects are dependent upon GCs binding to nuclear
Autor:
Julian C. Desmond, Takashi Kumagai, H. Phillip Koeffler, Martin Hewison, James O'Kelly, Susan V. Hughes, Lee-Yung Shih
Publikováno v:
Cancer Research. 65:2488-2497
Recently, we reported that a novel, noncalcemic vitamin D analogue (19-nor-1,25(OH)2D2; paricalcitol) had anticancer activity. In this study, we explored if paricalcitol enhanced anticancer effects of other clinically useful drugs in vitro against a
Autor:
Susan V. Hughes, Martin Hewison, Rosemary Bland, Susan L.F. Chan, Paul E. Squires, Claire E. Hills, Danijela Markovic
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. :121-125
A number of studies have suggested that Vitamin D has a potential role in the development/treatment of diabetes. These effects may be mediated by circulating levels of 1alpha,25(OH)(2)D(3), but local production of 1alpha,25(OH)(2)D(3), catalysed by t
Autor:
Rosemary Bland, Lisa M. Freeman, Katie N. Evans, Aristides G. Eliopoulos, Ronjon Chakraverty, Susan V. Hughes, Paul Moss, Mark D. Kilby, Martin Hewison
Publikováno v:
The Journal of Immunology. 170:5382-5390
The functions of dendritic cells (DCs) are tightly regulated such that protective immune responses are elicited and unwanted immune responses are prevented. 1 alpha 25-dihydroxyvitamin D(3) (1 alpha 25(OH)(2)D(3)) has been identified as a major facto