Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Susan V. Brooks"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
The development and maintenance of neuromuscular junctions (NMJ) are supported by a specialized population of myonuclei that are referred to as the subsynaptic myonuclei (SSM). The relationship between the number of SSM and the integrity of the NMJ a
Externí odkaz:
https://doaj.org/article/b02baecc79984a92a43acbef10d038d1
Autor:
Alan J. Russell, Mike DuVall, Ben Barthel, Ying Qian, Angela K. Peter, Breanne L. Newell-Stamper, Kevin Hunt, Sarah Lehman, Molly Madden, Stephen Schlachter, Ben Robertson, Ashleigh Van Deusen, Hector M. Rodriguez, Carlos Vera, Yu Su, Dennis R. Claflin, Susan V. Brooks, Peter Nghiem, Alexis Rutledge, Twlya I. Juehne, Jinsheng Yu, Elisabeth R. Barton, Yangyi E. Luo, Andreas Patsalos, Laszlo Nagy, H. Lee Sweeney, Leslie A. Leinwand, Kevin Koch
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by absence of the protein dystrophin, which acts as a structural link between the basal lamina and contractile machinery to stabilize muscle membranes in response to mechanical stres
Externí odkaz:
https://doaj.org/article/e747694ac75a437988e03985ae826a25
Autor:
Myungjin Kim, Alyson Sujkowski, Sim Namkoong, Bondong Gu, Tyler Cobb, Boyoung Kim, Allison H. Kowalsky, Chun-Seok Cho, Ian Semple, Seung-Hyun Ro, Carol Davis, Susan V. Brooks, Michael Karin, Robert J. Wessells, Jun Hee Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and in
Externí odkaz:
https://doaj.org/article/126b3fa1af5449268749287ab60d04c0
Autor:
Steve D. Guzman, Jennifer Judge, Shahjahan M. Shigdar, Thomas A. Paul, Carol S. Davis, Peter C. Macpherson, James F. Markworth, Holly Van Remmen, Arlan Richardson, Anne McArdle, Susan V. Brooks
Publikováno v:
Frontiers in Aging, Vol 2 (2022)
Aging results in the progressive accumulation of senescent cells in tissues that display loss of proliferative capacity and acquire a senescence-associated secretory phenotype (SASP). The tumor suppressor, p16INK4A, which slows the progression of the
Externí odkaz:
https://doaj.org/article/624eb338e7c1447186d014f1dd94f006
Autor:
Bumsoo Ahn, Rojina Ranjit, Pavithra Premkumar, Gavin Pharaoh, Katarzyna M. Piekarz, Satoshi Matsuzaki, Dennis R. Claflin, Kaitlyn Riddle, Jennifer Judge, Shylesh Bhaskaran, Kavithalakshmi Satara Natarajan, Erika Barboza, Benjamin Wronowski, Michael Kinter, Kenneth M. Humphries, Timothy M. Griffin, Willard M. Freeman, Arlan Richardson, Susan V. Brooks, Holly Van Remmen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 2, Pp 411-428 (2019)
Abstract Background Excess reactive oxygen species (ROS) and muscle weakness occur in parallel in multiple pathological conditions. However, the causative role of skeletal muscle mitochondrial ROS (mtROS) on neuromuscular junction (NMJ) morphology an
Externí odkaz:
https://doaj.org/article/bf068644f5f343948ea2be767d068283
Autor:
James F. Markworth, Lemuel A. Brown, Eunice Lim, Carolyn Floyd, Jacqueline Larouche, Jesus A. Castor-Macias, Kristoffer B. Sugg, Dylan C. Sarver, Peter C.D. Macpherson, Carol Davis, Carlos A. Aguilar, Krishna Rao Maddipati, Susan V. Brooks
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Specialized proresolving mediators (SPMs) actively limit inflammation and expedite its resolution by modulating leukocyte recruitment and function. Here we profiled intramuscular lipid mediators via liquid chromatography-tandem mass spectrometry–ba
Externí odkaz:
https://doaj.org/article/0c793e0487a74a72877e5b31113c104c
Autor:
Anna Shcherbina, Jacqueline Larouche, Paula Fraczek, Benjamin A. Yang, Lemuel A. Brown, James F. Markworth, Carolina H. Chung, Mehwish Khaliq, Kanishka de Silva, Jeongmoon J. Choi, Mohammad Fallahi-Sichani, Sriram Chandrasekaran, Young C. Jang, Susan V. Brooks, Carlos A. Aguilar
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107964- (2020)
Summary: During aging, there is a progressive loss of volume and function in skeletal muscle that impacts mobility and quality of life. The repair of skeletal muscle is regulated by tissue-resident stem cells called satellite cells (or muscle stem ce
Externí odkaz:
https://doaj.org/article/4c25cc2531574597b3eba84ef930cfd5
Autor:
Rizwan Qaisar, Shylesh Bhaskaran, Pavithra Premkumar, Rojina Ranjit, Kavithalakshmi Satara Natarajan, Bumsoo Ahn, Kaitlyn Riddle, Dennis R. Claflin, Arlan Richardson, Susan V. Brooks, Holly Van Remmen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 5, Pp 1003-1017 (2018)
Abstract Background We have previously shown that the deletion of the superoxide scavenger, CuZn superoxide dismutase, in mice (Sod1−/− mice) results in increased oxidative stress and an accelerated loss of skeletal muscle mass and force that mir
Externí odkaz:
https://doaj.org/article/1ad724d6e92545639f0dae9a584dc46b
Autor:
Lemuel A. Brown, Jennifer L. Judge, Peter C. Macpherson, Lauren G. Koch, Nathan R. Qi, Steven L. Britton, Susan V. Brooks
Publikováno v:
Data in Brief, Vol 27, Iss , Pp - (2019)
The data described below is related to the manuscript “Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training” [1]. Rodents exhibit age-related declines in skel
Externí odkaz:
https://doaj.org/article/927e20cbcd8b4a529f271e29133ea7c8
Autor:
Mattia Scalabrin, Natalie Pollock, Caroline A. Staunton, Susan V. Brooks, Anne McArdle, Malcolm J. Jackson, Aphrodite Vasilaki
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Previous studies have shown a significant increase in the mitochondrial generation of hydrogen peroxide (H2O2) and other peroxides in recently denervated muscle fibers. The mechanisms for generation of these peroxides and how the muscle responds to t
Externí odkaz:
https://doaj.org/article/96d2a5c4d3e945f595d9f718d64cfaf6