Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Susan V. Booker"'
Autor:
Judith A. Bacon, Ann-Marie Codori, Susan V. Booker, Francis M. Giardiello, Kristin L. Zawacki, Gloria M. Petersen, Jill Brensinger Trimbath, Diana L. Miglioretti, Kimberly Picarello
Publikováno v:
American Journal of Medical Genetics. :117-128
Children who carry a gene mutation for familial adenomatous polyposis are virtually certain to develop colorectal cancer without annual endoscopic screening and a colectomy when polyps appear. Predictive genetic testing can identify children who need
Autor:
Katharine E. Romans, Susan V. Booker, Francis M. Giardiello, Linda M. Hylind, Marcia Cruz-Correa
Publikováno v:
Gastroenterology. 122:641-645
Background & Aims: Management of patients with familial adenomatous polyposis (FAP) can consist of colectomy with ileorectal anastomosis (IRA). Sulindac, a nonsteroidal anti-inflammatory drug, causes regression of colorectal adenomas in the retained
Autor:
Michael Goggins, Robb E. Wilentz, Shibin Zhou, Elizabeth A. Montgomery, Pedram Argani, Katharine E. Romans, Manju Kaushal, Parul Bhargava, Ralph H. Hruban, Scott E. Kern, Susan V. Booker
Publikováno v:
The American Journal of Pathology. 158:537-542
The tumor-suppressor protein Dpc4 (Smad4, Madh4) regulates gene expression. On binding of an extracellular ligand of the extensive transforming growth factor (TGF) superfamily to its cognate receptor complex, latent cytoplasmic Dpc4 is activated and
Autor:
Patrick S. Houlihan, Francis M. Giardiello, Asif Rashid, Gloria M. Petersen, Stanley R. Hamilton, Susan V. Booker
Publikováno v:
Gastroenterology. 119:323-332
Background & Aims: Patients with hyperplastic polyposis are reported to have multiple and/or large hyperplastic polyps (HPs) and an increased risk of colorectal cancer, but the phenotype and genetic alterations in hyperplastic polyposis have not been
Autor:
Susan V. Booker, Steven N. Goodman, Jill D. Brensinger, Francis M. Giardiello, Johan Offerhaus, Marcia Cruz-Correa, Gloria M. Petersen, Anne C. Tersmette
Publikováno v:
Gastroenterology, 119(6), 1447-1453. W.B. Saunders Ltd
Background & Aims: The Peutz–Jeghers syndrome (PJS) is an autosomal dominant polyposis disorder with increased risk of multiple cancers, but literature estimates of risk vary. Methods: We performed an individual patient meta-analysis to determine t
Autor:
Takato Fujiwara, Patti A. Longo, Susan V. Booker, Joshua M. Stolker, Jeremy R. Jass, James R. Eshleman, Asif Rashid, Toshiaki Watanabe, Jin Jen, Jane Green, Bert Vogelstein, Hoguen Kim, Henry T. Lynch, Stanley R. Hamilton
Publikováno v:
The American Journal of Pathology. 153:1063-1078
A subset of hereditary and sporadic colorectal carcinomas is defined by microsatellite instability (MSI), but the spectra of gene mutations have not been characterized extensively. Thirty-nine hereditary nonpolyposis colorectal cancer syndrome carcin
Autor:
Stanley R. Hamilton, Linda M. Hylind, Gloria M. Petersen, Francis M. Giardiello, Rodger D. Parker, Judith A. Bacon, Jill D. Brensinger, Michael C. Luce, Susan V. Booker
Publikováno v:
New England Journal of Medicine. 336:823-827
The use of commercially available tests for genes linked to familial cancer has aroused concern about the impact of these tests on patients. Familial adenomatous polyposis is an autosomal dominant disease caused by a germ-line mutation of the adenoma
Autor:
Francis M. Giardiello, Susan V. Booker, Judith A. Bacon, Gloria M. Petersen, Ya Yu Tsai, Stanley R. Hamilton
Publikováno v:
Genetic Epidemiology. 14:435-446
Anecdotal reports of hereditary colorectal cancer suggest that genetic anticipation (earlier appearance in successive generations) occurs, but ascertainment bias and cohort effects confound this interpretation. Using approaches that correct for such
Autor:
Stanley R. Hamilton, J. A. Offerhaus, Anne J. Krush, Francis M. Giardiello, Linda M. Hylind, Jill D. Brensinger, Susan V. Booker, A. C. Tersmette
Publikováno v:
Gut, 38(4), 578-581. BMJ Publishing Group
BACKGROUND--Sulindac, a non-steroidal anti-inflammatory drug, causes regression of colorectal adenomas in patients with familial adenomatous polyposis (FAP) but the response is variable. Specific clinical factors predictive of sulindac induced regres
Autor:
Francis M. Giardiello, G. Johan A. Offerhaus, Anne C. Tersmette, Steven M. Powell, Ramon Parsons, Zane Cohen, Anne J. Krush, Fowzia Taqi, Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos, Gloria M. Petersen, Bernard Têtu, Jin Jen, Patricia A. Wood, Theresa Berk, Susan V. Booker, Bo Liu, Stanley R. Hamilton, Peter C. Burger
Publikováno v:
New England Journal of Medicine. 332:839-847
Turcot's syndrome is characterized clinically by the concurrence of a primary brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the molecular level.Fourteen families with Turcot's syndrome identified in two registri