Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Susan Togher"'
Autor:
Sara Montagner, Cristina Leoni, Stefan Emming, Giulia Della Chiara, Chiara Balestrieri, Iros Barozzi, Viviana Piccolo, Susan Togher, Myunggon Ko, Anjana Rao, Gioacchino Natoli, Silvia Monticelli
Publikováno v:
Cell Reports, Vol 15, Iss 7, Pp 1566-1579 (2016)
Summary: Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC). Here, we identified TET2 as a crucial regulator of mast cell differentiation and proliferation. In the abse
Externí odkaz:
https://doaj.org/article/40b26c13096e42519aa36b21a13ac9d2
Autor:
Sara Montagner, Cristina Leoni, Stefan Emming, Giulia Della Chiara, Chiara Balestrieri, Iros Barozzi, Viviana Piccolo, Susan Togher, Myunggon Ko, Anjana Rao, Gioacchino Natoli, Silvia Monticelli
Publikováno v:
Cell Reports, Vol 20, Iss 7, p 1744 (2017)
Externí odkaz:
https://doaj.org/article/facce51c002d4c5c9b88a837aba8c205
Autor:
Edahí González-Avalos, Anjana Rao, Ageliki Tsagaratou, William A. Pastor, Harri Lähdesmäki, Sini Rautio, Lukas Chavez, James P. Scott-Browne, Ellen V. Rothenberg, Susan Togher
Publikováno v:
NATURE IMMUNOLOGY. 18(1):45-53
TET proteins oxidize 5-methylcytosine in DNA to 5-hydroxymethylcytosine and other oxidation products. We found that simultaneous deletion of Tet2 and Tet3 in mouse CD4+CD8+ double-positive thymocytes resulted in dysregulated development and prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f13c44af2d78721d38c3ebe19b04ff6
https://doi.org/10.1038/ni.3630
https://doi.org/10.1038/ni.3630
Autor:
Anjana Rao, Susan Togher, Renata M. Pereira, Joyce K. Hu, Gustavo J. Martinez, Nicholas Bild, Shane Crotty, Jordan S. Crampton
Publikováno v:
The Journal of Immunology. 196:2015-2019
Follicular CD4+ Th (Tfh) cells provide B cell help in germinal center reactions that support class switching, somatic hypermutation, and the generation of high-affinity Abs. In this article, we show that deficiency in NFAT1 and NFAT2 in CD4+ T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::838f5f56958f6f67431b59863ccd5ed3
https://doi.org/10.4049/jimmunol.1501841
https://doi.org/10.4049/jimmunol.1501841
Autor:
Patrick G. Hogan, Shane Crotty, Anjana Rao, Vigo Heissmeyer, Susan Togher, Matthew E. Pipkin, K. Mark Ansel, Francesco Marangoni, Edward Y. Kim, Thorsten R. Mempel, Edward D. Lamperti, Harri Lähdesmäki, Tarmo Äijö, Gustavo J. Martinez, Renata M. Pereira, Yi Chen Zhang
Publikováno v:
Immunity, vol 42, iss 2
Immunity 42, 265–278 (2015)
Immunity 42, 265–278 (2015)
During persistent antigen stimulation, CD8(+) Tcells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the setting of tumors and infections. Here we demonstrate that the transcription factor NFAT cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95fff9c1b34bfe2cc82b60ebc00ee16
Autor:
Giuliana P, Mognol, Roberto, Spreafico, Victor, Wong, James P, Scott-Browne, Susan, Togher, Alexander, Hoffmann, Patrick G, Hogan, Anjana, Rao, Sara, Trifari
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(13)
Cancer cells can be recognized and attacked by CD8+ cytolytic T cells, but tumor-infiltrating T cells often become functionally incompetent (“exhausted”) and fail to destroy tumor cells. We show that T-cell exhaustion requires antigen recognition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::053a79b680e70c953895b7963c40b177
https://pubmed.ncbi.nlm.nih.gov/28283662
https://pubmed.ncbi.nlm.nih.gov/28283662
Autor:
Patrick G. Hogan, Anjana Rao, Sara Trifari, Susan Togher, Alexander Hoffmann, James P. Scott-Browne, Giuliana P. Mognol, Victor Wong, Roberto Spreafico
Publikováno v:
Proceedings of the National Academy of Sciences. 114
T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent antigen exposure, which occurs in chronic viral infections and cancer. Here we investigate the relation between gene expression and chromatin accessib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deb326983f5e4722414c73298aaf7bb7
https://doi.org/10.1073/pnas.1620498114
https://doi.org/10.1073/pnas.1620498114
Publikováno v:
Immunology and cell biology
The generation of CD8(+) T cells by vaccination represents an important goal for protective immunity to infectious pathogens. It is thus of utmost importance to understand the mechanisms involved in the generation of optimal CD8(+) T-cell responses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172f6b31bb381e2d44779754bc10984f
http://europepmc.org/articles/PMC4324096
http://europepmc.org/articles/PMC4324096
Autor:
Gustavo J Martinez, Joyce Hu, Renata Pereira, Jordan Crampton, Susan Togher, Nicholas Bild, Shane Crotty, Anjana Rao
Follicular helper T (Tfh) cells provide B cell help in germinal center reactions that support class switching, somatic hypermutation, and the generation of high-affinity antibodies. Here we show that deficiency in NFAT1 and NFAT2 in CD4+ T cells lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42a6d4e1b9b1b0e17a778bf0033994c
https://europepmc.org/articles/PMC4761453/
https://europepmc.org/articles/PMC4761453/
Autor:
Robert Tacke, Grzegorz Chodaczek, Shahram Salek-Ardakani, Helena Shaked, Amit Bar-Or, Minna U. Kaikkonen, Catherine C. Hedrick, Susan Togher, George Tweet, Alp Bugra Basat, Ayman Rezk, Christopher K. Glass, Graham D. Thomas, Amy Blatchley, Richard N. Hanna, Zbigniew Mikulski, Hozefa S. Bandukwala, Martin Darvas, Sonia Lai-Wing-Sun, Jacqueline Miller, Iftach Shaked, Heba Nowyhed
Publikováno v:
Nature immunology. 16(12)
The molecular mechanisms that link the sympathetic stress response and inflammation remain obscure. Here we found that the transcription factor Nr4a1 regulated the production of norepinephrine (NE) in macrophages and thereby limited experimental auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07d701b77799e742e6c41f7bdaee9d6
https://pubmed.ncbi.nlm.nih.gov/26580501
https://pubmed.ncbi.nlm.nih.gov/26580501