Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Susan T. Nielsen"'
Publikováno v:
Journal of Medicinal Chemistry. 38:4026-4032
Structural manipulation of polycyclic piperazinyl imide serotonergic agents led to the synthesis of compound 8, 2-[4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-4, 4a,5,5a,6,6a-hexahydro-4,6-ethenocycloprop[f]isoindole-1,3(2H,3 aH)-dione, which dem
Publikováno v:
ChemInform. 27
Structural manipulation of polycyclic piperazinyl imide serotonergic agents led to the synthesis of compound 8, 2-[4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-4, 4a,5,5a,6,6a-hexahydro-4,6-ethenocycloprop[f]isoindole-1,3(2H,3 aH)-dione, which dem
Publikováno v:
Digestive Diseases and Sciences. 36:461-470
A model of experimentally induced inflammatory bowel disease (IBD) featuring colitis, originally devised by Onderdonk and co-workers in guinea pigs, was modified to establish the optimal conditions for ulcer development. Upon varying the time of subc
Publikováno v:
Drug Development Research. 23:57-64
WY-26,769 (2-3-dihydro-2-(2-pyridinyl) thiazolo-[3,2-a]benzimidazole) is a gastric antisecretory agent that acts by inhibiting the parietal cell proton pump. In vitro, WY-26,769 was active against dbcAMP-stimulated aminopyrine uptake in isolated pari
Publikováno v:
Drug Development Research. 21:63-78
In an effort to develop an orally active, non-sedating H1-antagonist, compound Wy-49,051 was synthesized and examined in various in vivo and in vitro assays. In vitro, the compound possessed high affinity for H1 receptors (IC50 = 44 nM) and was found
Publikováno v:
European Journal of Medicinal Chemistry. 24:87-90
The synthesis of the title compound, a new histamine H2-receptor antagonist (pA2 = 8.2), (Wy-45,727; 7) is described. Its gastric acid anti-secretory potencies in the rat and dog were found to be significantly greater than those of cimetidine or rani
Autor:
John T. Haskins, George Edward Morris Husbands, Susan T. Nielsen, Ernest B. Sigg, Eric Anthony Muth, John A. Moyer
Publikováno v:
Biochemical Pharmacology. 35:4493-4497
The novel bicyclic compound Wy-45,030 [1-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl cyclohexanol, hydrochloride] exhibited a neurochemical profile predictive of antidepressant activity. Like the tricyclic antidepressants, it inhibited rat brain imipr
Publikováno v:
Analytical Biochemistry. 92:67-73
A technique for the preparation of microgram quantities of bovine parathyroid hormone (bPTH) labeled with carrier-free 125I to a specific activity of 1300 Ci/mmol is described. A restructured and simplified apparatus was used for electrolytic iodinat
Autor:
William F. Neuman, Susan T. Nielsen
Publikováno v:
Journal of Supramolecular Structure. 9:391-398
The effects of calcium ion on the adenylate cyclase system was studied in isolated, renal basal-lateral plasma membranes of the rat. Bovine parathyroid hormone (bPTH) and a guanyl triphosphate analogue, Gpp(NH)p were used to stimulate cyclase activit
Autor:
D. P. Strike, D. M. Teller, Susan T. Nielsen, Arthur A. Santilli, Robert L. Morris, Anthony C. Scotese, G. A. Schiehser
Publikováno v:
ChemInform. 19