Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Susan T. Harbison"'
Autor:
Matthew N. Eiman, Shailesh Kumar, Yazmin L. Serrano Negron, Terry R. Tansey, Susan T. Harbison
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Sleep latency, the amount of time that it takes an individual to fall asleep, is a key indicator of sleep need. Sleep latency varies considerably both among and within species and is heritable, but lacks a comprehensive description of its un
Externí odkaz:
https://doaj.org/article/0a21628befec43eb853a454ab578ee0f
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 9, Pp 2865-2873 (2018)
Understanding how genomic variation causes differences in observable phenotypes remains a major challenge in biology. It is difficult to trace the sequence of events originating from genomic variants to changes in transcriptional responses or protein
Externí odkaz:
https://doaj.org/article/45c5e4df60174612bea8e30a6aee9774
Autor:
Hangnoh Lee, Dong-Yeon Cho, Damian Wojtowicz, Susan T. Harbison, Steven Russell, Brian Oliver, Teresa M. Przytycka
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 2, Pp 587-598 (2018)
DNA copy number variation is associated with many high phenotypic heterogeneity disorders. We systematically examined the impact of Drosophila melanogaster deletions on gene expression profiles to ask whether increased expression variability owing to
Externí odkaz:
https://doaj.org/article/dd1c50f610af48258854681175631649
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 7, Pp 2391-2403 (2017)
Ovariole number has a direct role in the number of eggs produced by an insect, suggesting that it is a key morphological fitness trait. Many studies have documented the variability of ovariole number and its relationship to other fitness and life-his
Externí odkaz:
https://doaj.org/article/30132cb3e92548e38bd7e0bbf2c28ebe
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 12, Pp 4197-4210 (2016)
Differences in phenotype among genetically identical individuals exposed to the same environmental condition are often noted in genetic studies. Despite this commonplace observation, little is known about the causes of this variability, which has bee
Externí odkaz:
https://doaj.org/article/7a5459ff56aa45bc966ff8ac4b081a3b
Autor:
Susan T Harbison
Publikováno v:
Sleep
We investigated the potential role of sleep-trait associated genetic loci in conferring a degree of their effect via pancreatic α- and β-cells, given that both sleep disturbances and metabolic disorders, including type 2 diabetes and obesity, invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6049c765f911a536cffdd1e063d29382
https://pubmed.ncbi.nlm.nih.gov/35537191
https://pubmed.ncbi.nlm.nih.gov/35537191
Autor:
Richard F. Lyman, Rachel A. Lyman, Akihiko Yamamoto, Wen Huang, Susan T. Harbison, Shanshan Zhou, Robert R. H. Anholt, Trudy F. C. Mackay
Fertility is a major component of fitness but its genetic architecture remains poorly understood. Using a full diallel cross of 50 Drosophila melanogaster Genetic Reference Panel inbred lines with full genome sequences, we found substantial genetic v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c53c19102c343f833bc4773966edd51
https://doi.org/10.1101/2022.09.06.506722
https://doi.org/10.1101/2022.09.06.506722
Autor:
Susan T Harbison
Publikováno v:
Sleep. 45(11)
Selective breeding is a classic technique that enables an experimenter to modify a heritable target trait as desired. Direct selective breeding for extreme sleep and circadian phenotypes in flies successfully alters these behaviors, and sleep and cir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec03bde6927a2e5a75f9afef2d04f8d
https://pubmed.ncbi.nlm.nih.gov/36111812
https://pubmed.ncbi.nlm.nih.gov/36111812
Autor:
Wen Huang, Richard F Lyman, Rachel A Lyman, Mary Anna Carbone, Susan T Harbison, Michael M Magwire, Trudy FC Mackay
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/d0f0f5320eea4f09932fcac04f28bf8e
Autor:
Wen Huang, Richard F Lyman, Rachel A Lyman, Mary Anna Carbone, Susan T Harbison, Michael M Magwire, Trudy FC Mackay
Publikováno v:
eLife, Vol 5 (2016)
Mutation and natural selection shape the genetic variation in natural populations. Here, we directly estimated the spontaneous mutation rate by sequencing new Drosophila mutation accumulation lines maintained with minimal natural selection. We inferr
Externí odkaz:
https://doaj.org/article/beee1b02c57b454791f8d7e7594ea44b