Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Susan T Harbison"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 8, p e1011389 (2023)
All but the simplest phenotypes are believed to result from interactions between two or more genes forming complex networks of gene regulation. Sleep is a complex trait known to depend on the system of feedback loops of the circadian clock, and on ma
Externí odkaz:
https://doaj.org/article/9525d6e2f6194d66acf30afac89338e1
Publikováno v:
PLoS Genetics, Vol 13, Iss 12, p e1007098 (2017)
Why do some individuals need more sleep than others? Forward mutagenesis screens in flies using engineered mutations have established a clear genetic component to sleep duration, revealing mutants that convey very long or short sleep. Whether such ex
Externí odkaz:
https://doaj.org/article/6a97b450e9264896bf406992dd2cdb97
Autor:
Wen Huang, Richard F Lyman, Rachel A Lyman, Mary Anna Carbone, Susan T Harbison, Michael M Magwire, Trudy FC Mackay
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/d0f0f5320eea4f09932fcac04f28bf8e
Autor:
Wen Huang, Richard F Lyman, Rachel A Lyman, Mary Anna Carbone, Susan T Harbison, Michael M Magwire, Trudy FC Mackay
Publikováno v:
eLife, Vol 5 (2016)
Mutation and natural selection shape the genetic variation in natural populations. Here, we directly estimated the spontaneous mutation rate by sequencing new Drosophila mutation accumulation lines maintained with minimal natural selection. We inferr
Externí odkaz:
https://doaj.org/article/beee1b02c57b454791f8d7e7594ea44b
Autor:
Maria De Luca, Yann C Klimentidis, Krista Casazza, Michelle Moses Chambers, Ruth Cho, Susan T Harbison, Patricia Jumbo-Lucioni, Shaoyan Zhang, Jeff Leips, Jose R Fernandez
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11286 (2010)
Syndecans are a family of type-I transmembrane proteins that are involved in cell-matrix adhesion, migration, neuronal development, and inflammation. Previous quantitative genetic studies pinpointed Drosophila Syndecan (dSdc) as a positional candidat
Externí odkaz:
https://doaj.org/article/9e79af1dd01743c69dd8e94c665e6797
Autor:
Susan T Harbison, Amita Sehgal
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6211 (2009)
Recent human studies reveal a widespread association between short sleep and obesity. Two hypotheses, which are not mutually exclusive, might explain this association. First, genetic factors that reduce endogenous sleep times might also impact energy
Externí odkaz:
https://doaj.org/article/b1eb8b32d9ff498282265a27d701e7f9
Autor:
Susan T Harbison
Publikováno v:
Sleep
We investigated the potential role of sleep-trait associated genetic loci in conferring a degree of their effect via pancreatic α- and β-cells, given that both sleep disturbances and metabolic disorders, including type 2 diabetes and obesity, invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6049c765f911a536cffdd1e063d29382
https://pubmed.ncbi.nlm.nih.gov/35537191
https://pubmed.ncbi.nlm.nih.gov/35537191
Autor:
Richard F. Lyman, Rachel A. Lyman, Akihiko Yamamoto, Wen Huang, Susan T. Harbison, Shanshan Zhou, Robert R. H. Anholt, Trudy F. C. Mackay
Fertility is a major component of fitness but its genetic architecture remains poorly understood. Using a full diallel cross of 50 Drosophila melanogaster Genetic Reference Panel inbred lines with full genome sequences, we found substantial genetic v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c53c19102c343f833bc4773966edd51
https://doi.org/10.1101/2022.09.06.506722
https://doi.org/10.1101/2022.09.06.506722
Autor:
Susan T Harbison
Publikováno v:
Sleep. 45(11)
Selective breeding is a classic technique that enables an experimenter to modify a heritable target trait as desired. Direct selective breeding for extreme sleep and circadian phenotypes in flies successfully alters these behaviors, and sleep and cir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec03bde6927a2e5a75f9afef2d04f8d
https://pubmed.ncbi.nlm.nih.gov/36111812
https://pubmed.ncbi.nlm.nih.gov/36111812
Publikováno v:
Genetics
Behaviors associated with reproduction are major contributors to the evolutionary success of organisms and are subject to many evolutionary forces, including natural and sexual selection, and sexual conflict. Successful reproduction involves a range
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a28f674fabbece6bbb4bccc7010d117
http://europepmc.org/articles/PMC6944409
http://europepmc.org/articles/PMC6944409