Zobrazeno 1 - 10
of 356
pro vyhledávání: '"Susan T, Weintraub"'
Autor:
Camilo Hernández-Avilés, Luisa Ramírez-Agámez, Susan T. Weintraub, Charles F. Scoggin, Brian W. Davis, Terje Raudsepp, Dickson D. Varner, Charles C. Love
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Thoroughbred stallions that carry a double-homozygous genotype A/A-A/A for SNPs rs397316122 and rs69101140 in exon 5 of the FKBP6 gene (chr13; EquCab3.0) are uniquely subfertile due to impaired acrosomal exocytosis (IAE). In this study, the
Externí odkaz:
https://doaj.org/article/24ec28fad45d4cac88cfe0dada331666
Autor:
Kruthi Suvarna, Panneerselvam Jayabal, Xiuye Ma, Hu Wang, Yidong Chen, Susan T. Weintraub, Xianlin Han, Peter J. Houghton, Yuzuru Shiio
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114497- (2024)
Summary: Ewing sarcoma is a cancer of bone and soft tissue in children and young adults primarily driven by the EWS-FLI1 fusion oncoprotein, which has been undruggable. Here, we report that Ewing sarcoma depends on secreted sphingomyelin phosphodiest
Externí odkaz:
https://doaj.org/article/27da5815e62a4b5a8646c0cebf73abc7
Autor:
Joshua M. Lorenz-Guertin, Nadya Povysheva, Caitlyn A. Chapman, Matthew L. MacDonald, Marco Fazzari, Aparna Nigam, Jessica L. Nuwer, Sabyasachi Das, Megan L. Brady, Katarina Vajn, Matthew J. Bambino, Susan T. Weintraub, Jon W. Johnson, Tija C. Jacob
Publikováno v:
Neurobiology of Disease, Vol 185, Iss , Pp 106248- (2023)
Benzodiazepine (BZ) drugs treat seizures, anxiety, insomnia, and alcohol withdrawal by potentiating γ2 subunit containing GABA type A receptors (GABAARs). BZ clinical use is hampered by tolerance and withdrawal symptoms including heightened seizure
Externí odkaz:
https://doaj.org/article/ad34633e407d4057b7e50eb452454154
Autor:
Frank Herkules, Corey H. Yu, Alexander B. Taylor, Vi Dougherty, Susan T. Weintraub, Dmitri N. Ivanov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
TRIM5α is an E3 ligase that inhibits retroviral replication. Here, the authors delineate the biochemical mechanism that accelerates N terminal autoubiquitylation of TRIM5α upon its association with the retroviral capsid and, thus, enables recogniti
Externí odkaz:
https://doaj.org/article/63cd2a27a1a34e95a00aa3b12f5fa273
Autor:
Panneerselvam Jayabal, Fuchun Zhou, Xiuye Ma, Kathryn M. Bondra, Barron Blackman, Susan T. Weintraub, Yidong Chen, Patricia Chévez-Barrios, Peter J. Houghton, Brenda Gallie, Yuzuru Shiio
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112103- (2023)
Summary: Retinoblastoma is a cancer of the infant retina primarily driven by loss of the Rb tumor suppressor gene, which is undruggable. Here, we report an autocrine signaling, mediated by secreted frizzled-related protein 2 (SFRP2), which suppresses
Externí odkaz:
https://doaj.org/article/27ad92eeeb834f53a5628e23b99cd2a9
Autor:
Dongwen Lv, Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang, Wanyi Hu, Jing Pei, Qi Zhang, Shuo Zhou, Sajid Khan, Xuan Zhang, Nan Hua, Qingping Yang, Sebastian Arango, Weizhou Zhang, Digant Nayak, Shaun K. Olsen, Susan T. Weintraub, Robert Hromas, Marina Konopleva, Yaxia Yuan, Guangrong Zheng, Daohong Zhou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Simultaneous targeting of BCL-xL and BCL-2 is an attractive approach for cancer treatment. Based on information gained by computational structure modelling, the authors develop a PROTAC that induces degradation of both BCL-xL and BCL-2 and effectivel
Externí odkaz:
https://doaj.org/article/38d97353bbbf41e4aa6eb4a5907c3bd4
Autor:
Dae D. Chung, Marisa R. Pinson, Amanda H. Mahnke, Nihal A. Salem, Khang T. Le, Elizabeth A. Payne, Tenley E. Lehman, Susan T. Weintraub, Rajesh C. Miranda
Publikováno v:
Heliyon, Vol 8, Iss 11, Pp e11348- (2022)
Accumulating evidence indicates that extracellular vesicles (EVs) mediate endocrine functions and also pathogenic effects of neurodevelopmental perturbagens like ethanol. We performed mass-spectrometry on EVs secreted by fetal murine cerebral cortica
Externí odkaz:
https://doaj.org/article/6d2763162b7e4452a0e52f9d6f1eb21f
Siphophage 0105phi7-2 of Bacillus thuringiensis: Novel Propagation, DNA, and Genome-Implied Assembly
Autor:
Samantha M. Roberts, Miranda Aldis, Elena T. Wright, Cara B. Gonzales, Zhao Lai, Susan T. Weintraub, Stephen C. Hardies, Philip Serwer
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8941 (2023)
Diversity of phage propagation, physical properties, and assembly promotes the use of phages in ecological studies and biomedicine. However, observed phage diversity is incomplete. Bacillus thuringiensis siphophage, 0105phi-7-2, first described here,
Externí odkaz:
https://doaj.org/article/5ed1dffd2b4d4357aea5ec0396a9a49a
Autor:
Aaron Scheuch, Sara A. M. Moran, Julia N. Faraone, Sophia R. Unwin, Gialinh Vu, Andrea Denisse Benítez, Nurul Humaira Mohd Redzuan, Dana Molleur, Sammy Pardo, Susan T. Weintraub, Julie A. Thomas
Publikováno v:
Viruses, Vol 15, Iss 3, p 723 (2023)
Salmonella myovirus SPN3US has a T = 27 capsid composed of >50 different gene products, including many that are packaged along with the 240 kb genome and ejected into the host cell. Recently, we showed that an essential phage-encoded prohead protease
Externí odkaz:
https://doaj.org/article/c5b82845459b454b8e48a4749ccd70eb
Autor:
Subash Adhikari, Edouard C. Nice, Eric W. Deutsch, Lydie Lane, Gilbert S. Omenn, Stephen R. Pennington, Young-Ki Paik, Christopher M. Overall, Fernando J. Corrales, Ileana M. Cristea, Jennifer E. Van Eyk, Mathias Uhlén, Cecilia Lindskog, Daniel W. Chan, Amos Bairoch, James C. Waddington, Joshua L. Justice, Joshua LaBaer, Henry Rodriguez, Fuchu He, Markus Kostrzewa, Peipei Ping, Rebekah L. Gundry, Peter Stewart, Sanjeeva Srivastava, Sudhir Srivastava, Fabio C. S. Nogueira, Gilberto B. Domont, Yves Vandenbrouck, Maggie P. Y. Lam, Sara Wennersten, Juan Antonio Vizcaino, Marc Wilkins, Jochen M. Schwenk, Emma Lundberg, Nuno Bandeira, Gyorgy Marko-Varga, Susan T. Weintraub, Charles Pineau, Ulrike Kusebauch, Robert L. Moritz, Seong Beom Ahn, Magnus Palmblad, Michael P. Snyder, Ruedi Aebersold, Mark S. Baker
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The Human Proteome Project (HPP) was launched in 2010 to enhance accurate annotation of the genome-encoded proteome. Ten years later, the HPP releases its first blueprint of the human proteome, annotating 90% of all known proteins at high-stringency
Externí odkaz:
https://doaj.org/article/bb037a5bb053476e9a3946b7578e5277