Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Susan Stasiuk"'
Autor:
Francesca Jean, Susan Stasiuk, Tatiana Maroilley, Catherine Diao, Andrew Galbraith, Maja Tarailo-Graovac
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Intragenic modifiers (in-phase, second-site variants) are known to have dramatic effects on clinical outcomes, affecting disease attributes such as severity or age of onset. However, despite their clinical importance, the focus of
Externí odkaz:
https://doaj.org/article/89e331a0c6c34531acfc0e878d10e41d
Autor:
Andrew R. Burns, Genna M. Luciani, Gabriel Musso, Rachel Bagg, May Yeo, Yuqian Zhang, Luckshi Rajendran, John Glavin, Robert Hunter, Elizabeth Redman, Susan Stasiuk, Michael Schertzberg, G. Angus McQuibban, Conor R. Caffrey, Sean R. Cutler, Mike Tyers, Guri Giaever, Corey Nislow, Andy G. Fraser, Calum A. MacRae, John Gilleard, Peter J. Roy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f372221257b04ca99777a3b815bb1dd0
Autor:
Susan Stasiuk, Francesca Jean, Tatiana Maroilley, Catherine Diao, Andrew J. Galbraith, Maja Tarailo-Graovac
Publikováno v:
BMC Genomics
BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)
BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)
Background Intragenic modifiers (in-phase, second-site variants) are known to have dramatic effects on clinical outcomes, affecting disease attributes such as severity or age of onset. However, despite their clinical importance, the focus of many gen
Autor:
Maja Tarailo-Graovac, Tatiana Maroilley, Matthew J. Oldach, Francesca Jean, Susan Stasiuk, Xiao Li
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Genomic rearrangements cause congenital disorders, cancer, and complex diseases in human. Yet, they are still understudied in rare diseases because their detection is challenging, despite the advent of whole genome sequencing (WGS) technologies. Shor
Autor:
Elizabeth Redman, Eileen Devaney, John S. Gilleard, Susan Stasiuk, Roz Laing, Axel Martinelli, Stephen R. Doyle, D.J. Bartley, Andrew M. Rezansoff, Neil Sargison, Nancy Holroyd, James Cotton
Publikováno v:
Rezansoff, A M, Laing, R, Martinelli, A, Stasiuk, S, Redman, E, Bartley, D, Holroyd, N, Devaney, E, Sargison, N D, Doyle, S, Cotton, J A & Gilleard, J S 2019, ' The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus ', International Journal For Parasitology, vol. 49, no. 11 . https://doi.org/10.1016/j.ijpara.2019.05.012
Differential expression analysis between parasitic nematode strains is commonly used to implicate candidate genes in anthelmintic resistance or other biological functions. We have tested the hypothesis that the high genetic diversity of an organism s
Autor:
Douglas D. Colwell, Elizabeth Redman, Susan Stasiuk, John S. Gilleard, D.J. Bartley, Gillian MacNevin, N. Sharma, Dae-Kyun Ro, Alison A. Morrison, D. Gray, Matthew L. Workentine
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 11, Iss, Pp 13-29 (2019)
International Journal for Parasitology: Drugs and Drug Resistance, Vol 11, Iss, Pp 13-29 (2019)
We have undertaken a detailed analysis of the biotransformation of five of the most therapeutically important benzimidazole anthelmintics - albendazole (ABZ), mebendazole (MBZ), thiabendazole (TBZ), oxfendazole (OxBZ) and fenbendazole (FBZ) - in Caen
Autor:
Corey Nislow, Genna M. Luciani, Sean R. Cutler, Yuqian Zhang, G. Angus McQuibban, Peter J. Roy, John Glavin, Mike Tyers, Guri Giaever, Conor R. Caffrey, Luckshi Rajendran, Gabriel Musso, Rachel Bagg, Andrew G. Fraser, John S. Gilleard, Andrew R. Burns, Michael R Schertzberg, Elizabeth Redman, May Yeo, Susan Stasiuk, Calum A. MacRae, Robert Hunter
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Parasitic nematodes infect one quarter of the world's population and impact all humans through widespread infection of crops and livestock. Resistance to current anthelmintics has prompted the search for new drugs. Traditional screens that rely on pa
Autor:
Robert Hunter, Mike Tyers, Genna M. Luciani, Sean R. Cutler, Yuqian Zhang, G. Angus McQuibban, Luckshika Rajendran, Conor R. Caffrey, Elizabeth Redman, Rachel Bagg, Susan Stasiuk, John Glavin, Guri Giaever, Corey Nislow, Andrew G. Fraser, Michael R Schertzberg, May Yeo, John S. Gilleard, Andrew R. Burns, Gabriel Musso, Peter J. Roy, Calum A. MacRae
Publikováno v:
Nature Communications
Parasitic nematodes infect one quarter of the world’s population and impact all humans through widespread infection of crops and livestock. Resistance to current anthelmintics has prompted the search for new drugs. Traditional screens that rely on