Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Susan Specht"'
Autor:
Yoshiaki Mizuguchi, Susan Specht, John G Lunz, Kumiko Isse, Natasha Corbitt, Toshihiro Takizawa, Anthony J Demetris
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32449 (2012)
Epithelial to mesenchymal transition (EMT) not only occurs during embryonic development and in response to injury, but is an important element in cancer progression. EMT and its reverse process, mesenchymal to epithelial transition (MET) is controlle
Externí odkaz:
https://doaj.org/article/21b7958972254d4bade937c2d8803708
Publikováno v:
Cell Transplantation, Vol 15 (2006)
An increasing need for liver transplantation requires evaluation and triage of organs harvested from “extended criteria” donors. Although there is currently no widely accepted definition, most would agree that “extended criteria” includes org
Externí odkaz:
https://doaj.org/article/4ecd6034eceb4ee1b5f8bbf32351a63b
Autor:
Yoshiaki Mizuguchi, Toshihiro Takizawa, Natasha Corbitt, Anthony J. Demetris, John G. Lunz, Kumiko Isse, Susan Specht
Publikováno v:
Hepatology. 59:1130-1143
STAT3-driven expression of small proline rich protein 2a (SPRR2a), which acts as an src homology 3 (SH3) domain ligand, induces biliary epithelial cell (BEC) epithelial-mesenchymal transition (EMT), which, in turn, promotes wound healing. SPRR2a also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9577039f926115e514e75ae0d132495f
https://doi.org/10.1002/hep.26889
https://doi.org/10.1002/hep.26889
Autor:
Andrew Lesniak, John Maier, John G. Lunz, Badrinath Roysam, Marcela Castillo-Rama, Kedar Grama, Susan Specht, Kumiko Isse, George K. Michalopoulos, Anthony J. Demetris
Publikováno v:
Hepatology. 57:1632-1643
Routine light microscopy identifies two distinct epithelial cell populations in normal human livers: hepatocytes and biliary epithelial cells (BECs). Considerable epithelial diversity, however, arises during disease states when a variety of hepatocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884f2ed8eaa6fb19420f35619caa8087
https://doi.org/10.1002/hep.26131
https://doi.org/10.1002/hep.26131
Autor:
Susan Specht, John G. Lunz, Liang-I Kang, Yoshiaki Mizuguchi, Anthony J. Demetris, Kumiko Isse
Publikováno v:
Hepatology. 51:869-880
Females are more susceptible than males to several biliary tract diseases. Interleukin-6 (IL-6) is critical to triggering autoimmune reactions and contributes substantially to biliary epithelial cell (BEC) barrier function and wound repair, and estro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfa249a96641fa688ce11225439b734
https://doi.org/10.1002/hep.23386
https://doi.org/10.1002/hep.23386
Publikováno v:
Hepatology. 46:1946-1959
Intraorgan dendritic cells (DCs) monitor the environment and help translate triggers of innate immunity into adaptive immune responses. Liver-based DCs are continually exposed, via gut-derived portal venous blood, to potential antigens and bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f0e8ba9462141d4767e7d02e967eaf
https://doi.org/10.1002/hep.21906
https://doi.org/10.1002/hep.21906
Autor:
Ashley E. Lamborn, Amy S. Garst, David Ayares, Todd Vaught, Kevin D. Wells, Thomas E. Starzl, Sugandha B. Sharma, Carol Phelps, Yifan Dai, Jeff A. Monahan, Marilyn Moore, Irina A. Polejaeva, Suyapa Ball, Shu-Hung Chen, Chihiro Koike, Susan Specht, Rita Bottino, Anthony J. Demetris, Pete M. Jobst, Suzanne Bertera, Massimo Trucco, Jeremy Boone, William A. Rudert
Publikováno v:
Science. 299:411-414
The enzyme alpha1,3-galactosyltransferase (alpha1,3GT or GGTA1) synthesizes alpha1,3-galactose (alpha1,3Gal) epitopes (Galalpha1,3Galbeta1,4GlcNAc-R), which are the major xenoantigens causing hyperacute rejection in pig-to-human xenotransplantation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acfb7a02e30eb59bb88e2b45d9bab02
https://doi.org/10.1126/science.1078942
https://doi.org/10.1126/science.1078942
Publikováno v:
The Journal of Immunology. 168:143-154
CD8α+ and CD8α− dendritic cells (DCs) arise from committed bone marrow progenitors and can induce or regulate immune reactivity. Previously, the maturational status of CD8α− (myeloid) DCs has been shown to influence allogeneic T cell responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f629630be5f54e197e5a479684ca523
https://doi.org/10.4049/jimmunol.168.1.143
https://doi.org/10.4049/jimmunol.168.1.143
Autor:
Yoshiaki Mizuguchi, Toshihiro Takizawa, Kumiko Isse, Susan Specht, Eizaburo Sasatomi, John G. Lunz, Anthony J. Demetris
Publikováno v:
Journal of hepatology. 63(2)
Background & Aims Breast tumor kinase (BRK) augments proliferation and promotes cell survival in breast cancers via interactions with SH2 and SH3 ligand-containing proteins, such as receptor tyrosine kinases (RTK; e.g. EGFR, ErbB2/neu). Since RTK con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e471be3db0a28a0a3c25abd8a08551b
https://pubmed.ncbi.nlm.nih.gov/25770659
https://pubmed.ncbi.nlm.nih.gov/25770659
Autor:
Barbara Rominski, Andrea Jaquins-Gerstl, Patrick Luke, Angus W. Thomson, Susan Specht, Shigehiko Koga, Rosemary A. Hoffman, Mark L. Jordan
Publikováno v:
Transplantation. 70:1788-1796
Background. Donor-specific blood transfusion (DST) may improve allograft survival in human and animal models, but the mechanisms for this graft protective effect are incompletely understood. The sponge matrix allograft model was used to determine if
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc33aa3fb6ec0fed62c895fe3fd2fa6d
https://doi.org/10.1097/00007890-200012270-00019
https://doi.org/10.1097/00007890-200012270-00019