Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Susan Slowe"'
Autor:
Ian Kitchen, Alexis Bailey, Hans W. D. Matthes, Susanna M.O. Hourani, Brigitte L. Kieffer, Susan Slowe
Publikováno v:
Brain Research. 943:68-79
There is a large body of evidence indicating important interactions between the adenosine and opioid systems in regulating pain at both the spinal and supraspinal level. Mice lacking the mu-opioid receptor (MOR) gene have been successfully developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee48c2012d90221a0fa638e2e9bda4f
https://doi.org/10.1016/s0006-8993(02)02536-2
https://doi.org/10.1016/s0006-8993(02)02536-2
Publikováno v:
Brain Research. 818:335-345
Mice deficient in the κ-opioid receptor (KOR) gene have recently been developed by the technique of homologous recombination and shown to lack behavioural responses to the selective κ1-receptor agonist U-50,488H. We have carried out quantitative au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f219d08bd507ab878e89e20d8fcd372c
https://doi.org/10.1016/s0006-8993(98)01201-3
https://doi.org/10.1016/s0006-8993(98)01201-3
Autor:
Susan Slowe, Rafael Maldonado, Claire Smadja, Frédéric Simonin, Ian Kitchen, Olga Valverde, Bernard P. Roques, Marianne Le Meur, Andrée Dierich, Brigitte L. Kieffer
Publikováno v:
EMBO Journal
EMBO Journal, 1998, 17 (4), pp.886-897. ⟨10.1093/emboj/17.4.886⟩
EMBO Journal, 1998, 17 (4), pp.886-897. ⟨10.1093/emboj/17.4.886⟩
International audience; ***micro***-, delta- and kappa-opioid receptors are widely expressed in the central nervous system where they mediate the strong analgesic and mood-altering actions of opioids, and modulate numerous endogenous functions. To in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a9cc325a34a89b3d4059f75938468d
https://doi.org/10.1093/emboj/17.4.886
https://doi.org/10.1093/emboj/17.4.886
Autor:
Rafael Maldonado, Frédéric Simonin, Pascal Dollé, Marianne Le Meur, Ian Kitchen, Hans W. D. Matthes, Susan Slowe, Eleni T. Tzavara, Katia Befort, Bernard P. Roques, Olga Valverde, Brigitte L. Kieffer, Andrée Dierich, Jacques Hanoune
Publikováno v:
Nature. 383:819-823
Despite tremendous efforts in the search for safe, efficacious and non-addictive opioids for pain treatment, morphine remains the most valuable painkiller in contemporary medicine. Opioids exert their pharmacological actions through three opioid-rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40474f46bad6c6e03674f5878dac357e
https://doi.org/10.1038/383819a0
https://doi.org/10.1038/383819a0
Autor:
Frédéric Simonin, Brigitte L. Kieffer, Ian Kitchen, Johanna Chluba, Jérôme A.J. Becker, Hans W. D. Matthes, Susan Slowe, Dominique Filliol
Publikováno v:
European journal of pharmacology. 414(2-3)
Despite ample pharmacological evidence for the existence of multiple mu-, delta- and kappa-opioid receptor subtypes, only three genes encoding mu-(MOR), delta-(DOR) and kappa-(KOR) opioid receptor have been cloned. The KOR gene encodes kappa(1)-sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad19e896dcd101e997187f231f1fe56c
https://pubmed.ncbi.nlm.nih.gov/11239918
https://pubmed.ncbi.nlm.nih.gov/11239918
Autor:
Robin James Goody, S Clarke, Roberta Lattanzi, Frédéric Simonin, Ian Kitchen, Dominique Filliol, Susan Slowe, Lucia Negri, Brigitte L. Kieffer, Isabelle Lena, Hans W. D. Matthes
The opioid receptor-like 1 (ORL1) receptor shares a high degree of sequence homology with the classical mu-, delta- and kappa-opioid receptors and a functional mutual opposition between these receptors has been suggested. To further address this poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc5d19c48fcd4a1442222e5dbf8830a
http://hdl.handle.net/11573/131600
http://hdl.handle.net/11573/131600
Publikováno v:
Brain research. 778(1)
Mice lacking the mu-opioid receptor (MOR) gene have been successfully developed by homologous recombination and these animals show complete loss of analgesic responses to morphine as well as loss of place-preference activity and physical dependence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f42e2f268ec163b80324b8aa1b59e6
https://pubmed.ncbi.nlm.nih.gov/9462879
https://pubmed.ncbi.nlm.nih.gov/9462879