Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Susan Simerson"'
Autor:
Jonathan Chang, David Plouffe, Tove Tuntland, Tao Wu, Tomoyo Sakata, Kelli Kuhen, Nathanael S. Gray, Zhong Chen, John Isbell, David C. Tully, Elizabeth A. Winzeler, Arnab K. Chatterjee, Steven Howard, Xianming Deng, Susan Simerson, Jared Ek, Advait Nagle, Kerstin Henson, Francisco Adrian
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(14)
A novel family of 1H-imidazol-2-yl-pyrimidine-4,6-diamines has been identified with potent activity against the erythrocyte-stage of Plasmodium falciparum (Pf), the most common causative agent of malaria. A systematic SAR study resulted in the identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a44d9995875d0971ffe636ecc71023
https://pubmed.ncbi.nlm.nih.gov/20610151
https://pubmed.ncbi.nlm.nih.gov/20610151
Autor:
Jared Ek, Steven Howard, Kerstin Henson, Advait Nagle, Jonathan Chang, Tao Wu, Arnab K. Chatterjee, Zhong Chen, Susan Simerson, Elizabeth A. Winzeler, David Plouffe, Tove Tuntland, Francisco Adrian, Kelli Kuhen, Nathanael S. Gray, Tomoyo Sakata, Rachel Borboa, John Isbell, David C. Tully, Xianming Deng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Screening our in-house compound collection using a cell based Plasmodium falciparum proliferation assay we discovered a known pan-kinase inhibitor scaffold as a hit. Further optimization of this series led us to a novel benzam
Screening our in-house compound collection using a cell based Plasmodium falciparum proliferation assay we discovered a known pan-kinase inhibitor scaffold as a hit. Further optimization of this series led us to a novel benzam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22eb202a0c43199531ca1c75e5547e0
https://pubmed.ncbi.nlm.nih.gov/19879133
https://pubmed.ncbi.nlm.nih.gov/19879133
Autor:
Saraswathi Patthi, Ann F. McCue, Steven B. Ellis, Gonul Velicelebi, Daniel H. Feldman, Michael M. Harpold, Paul Brust, Susan Simerson, Azarnoush Maroufi, Mark E. Williams
Publikováno v:
Science (New York, N.Y.). 257(5068)
N-type calcium channels are omega-conotoxin (omega-CgTx)-sensitive, voltage-dependent ion channels involved in the control of neurotransmitter release from neurons. Multiple subtypes of voltage-dependent calcium channel complexes exist, and it is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea39940545c6a0913f54b476b43f8ae
https://pubmed.ncbi.nlm.nih.gov/1321501
https://pubmed.ncbi.nlm.nih.gov/1321501
Publikováno v:
Journal of Biological Chemistry. 263:19363-19369
We demonstrate here that rat lung membrane vasoactive intestinal peptide (VIP) receptors can be extracted in the active state using digitonin. Sepharose 4B gel filtration chromatography was utilized to demonstrate the formation of specific binding co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae18337969b6140df75f232e4e20a17c
https://doi.org/10.1016/s0021-9258(19)77642-x
https://doi.org/10.1016/s0021-9258(19)77642-x
Publikováno v:
Annals of the New York Academy of Sciences. 527:266-281
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eeeb393d930a49ce4ab856289c1a883
https://doi.org/10.1111/j.1749-6632.1988.tb26986.x
https://doi.org/10.1111/j.1749-6632.1988.tb26986.x