Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Susan Shilcrat"'
Autor:
Payne Andrew H, Christopher McKay, Peter R. Clark, Anna L. Dunn, Kevin Arendt, Susan Shilcrat, Katherine Wheelhouse, Frank Dixon, Glynn D. Williams
Publikováno v:
Journal of Chemical Education. 98:175-182
Awareness of best safety practices in the industrial sector will allow students in chemistry and chemical engineering programs to apply these approaches to their own safety assessments. Process safety is a critical function within the pharmaceutical
Autor:
Susan Shilcrat
Publikováno v:
Organic Process Research & Development. 15:1464-1469
An investigation of a runaway chemical reaction in the laboratory highlighted the potential hazards of oxidation chemistry involving hydrogen peroxide in the presence of tungsten catalysts. Under the process conditions, a combination of a high adiaba
Autor:
Daniel B. Patience, Lynette M. Oh, Huan Wang, Joseph Sisko, P. Grant Spoors, Robert E. Herrmann, Susan Shilcrat
Publikováno v:
Organic Process Research & Development. 11:1032-1042
A scalable synthesis of GSK183390A, a PPAR α/γ agonist, is described. This synthesis is highlighted by (1) a regioselective formal 1,3-dipolar cycloaddition reaction between an enamine and a nitrile imine dipole to form a 1,3,5-trisubstituted pyraz
Autor:
Susan Shilcrat, Michael D. Wallace, Lynn Goldfinger, Wenning Dai, Li Liu, Marvin Sungwhan Yu, Michael A. McGuire
Publikováno v:
Organic Process Research & Development. 8:738-743
The development of a novel, cost-effective synthesis of the vitronectin receptor antagonist SB-273005 became necessary as the compound proceeded to Phase 1. A practical synthesis of the compound presented challenges to the process chemist. Chief amon
Publikováno v:
Tetrahedron Letters. 40:3293-3296
The 4-aryl-3, 4-dihydrocoumarin1 is a critical intermediate in the synthesis of two endothelin receptor antagonists. Asymmetry is introduced by the chiral catalytic hydrogenation of2. Reduction occurs only if the lactone is open (3). A number of chir
Publikováno v:
The Journal of Organic Chemistry. 58:5107-5117
The aldol reaction of enantiopure N-(haloacetyl)-2-oxazolidinone enolates with aromatic aldehydes was studied for conditions that would induce the reaction to yield predominantly anti adducts. It was found herein that the inherent steric and stereoel
Publikováno v:
ChemInform. 29
A new method is presented for the preparation of 1,2-disubstitued-1H-imidazole-5-carboxaldehydes by the reaction of N-monosubstituted amidines with 2-halo-3-alkoxy-2-propenals. The reaction is highly regioselective with ratios of 1,2,5:1,2,4-imidazol
Autor:
Ivan Lantos, Don E. Griswold, Drake S. Eggleston, W Paul, Lendon N. Pridgen, David T. Hill, Susan Shilcrat, Paul Elliot Bender
Publikováno v:
Journal of Heterocyclic Chemistry. 28:1181-1187
A regiospecific synthesis of 6-phenyl-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]thiazole (2) was accomplished by treatment of 6-phenyl-2,3-dihydroimidazo[2,1-b]thiazole (10) with the reactive complex of pyridine and ethyl chloroformate followed by oxida
Autor:
Charles DeBrosse, Ann M. Tickner-Eldridge, R. Curtis Haltiwanger, Lendon N. Pridgen, Susan Shilcrat, Kris Huang
Publikováno v:
Synlett. 1999:1612-1614
Publikováno v:
The Journal of organic chemistry. 62(24)
A new method is presented for the preparation of 1,2-disubstitued-1H-imidazole-5-carboxaldehydes by the reaction of N-monosubstituted amidines with 2-halo-3-alkoxy-2-propenals. The reaction is highly regioselective with ratios of 1,2,5:1,2,4-imidazol