Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Susan Sheehan"'
Autor:
Hope Dang, Raul Castro-Portuguez, Luis Espejo, Grant Backer, Samuel Freitas, Erica Spence, Jeremy Meyers, Karissa Shuck, Emily A. Gardea, Leah M. Chang, Jonah Balsa, Niall Thorns, Caroline Corban, Teresa Liu, Shannon Bean, Susan Sheehan, Ron Korstanje, George L. Sutphin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Tryptophan metabolism through the kynurenine pathway influences molecular processes critical to healthy aging including immune signaling, redox homeostasis, and energy production. Aberrant kynurenine metabolism occurs during normal aging and
Externí odkaz:
https://doaj.org/article/d818b49f9ce9488ab1b9a7b0ec1eae58
Autor:
Bradford T. Hull, Kayla M. Miller, Caroline Corban, Grant Backer, Susan Sheehan, Ron Korstanje, George L. Sutphin
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 599 (2024)
Age is the primary risk factor for neurodegenerative diseases such as Alzheimer’s and Huntington’s disease. Alzheimer’s disease is the most common form of dementia and a leading cause of death in the elderly population of the United States. No
Externí odkaz:
https://doaj.org/article/bef735e36d3c4f668da9249f8e418de8
Autor:
Theun de Groot, Lars Damen, Leanne Kosse, Mohammad Alsady, Rosalinda Doty, Ruben Baumgarten, Susan Sheehan, Johan van der Vlag, Ron Korstanje, Peter M T Deen
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189485 (2017)
Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and glomerulos
Externí odkaz:
https://doaj.org/article/fc0e4e661fe24763ab22800ae06b1802
Autor:
Magalie S. Leduc, Malcolm Lyons, Katayoon Darvishi, Kenneth Walsh, Susan Sheehan, Sarah Amend, Allison Cox, Marju Orho-Melander, Sekar Kathiresan, Beverly Paigen, Ron Korstanje
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 6, Pp 1139-1149 (2011)
Genome-wide association (GWA) studies represent a powerful strategy for identifying susceptibility genes for complex diseases in human populations but results must be confirmed and replicated. Because of the close homology between mouse and human gen
Externí odkaz:
https://doaj.org/article/e2516ad026464a8a95d9e7d542358a9c
Autor:
Zhiguang Su, Xiaosong Wang, Shirng-Wern Tsaih, Aihong Zhang, Allison Cox, Susan Sheehan, Beverly Paigen
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 1, Pp 116-125 (2009)
To evaluate the effect of genetic background on high-density lipoprotein cholesterol (HDL) levels in Soat1−/− mice, we backcrossed sterol O-acyltransferase 1 (Soat1)−/− mice, originally reported to have elevated HDL levels, to C57BL/6 mice an
Externí odkaz:
https://doaj.org/article/7fd3c33d892a40eba1f4502ea47d2e36
Autor:
Thuy Thai, Susan Sheehan
Publikováno v:
Language Education and Assessment. 5:34-51
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd30917913c2713ec6f76b11857dc6dd
https://doi.org/10.29140/lea.v5n1.777
https://doi.org/10.29140/lea.v5n1.777
Autor:
Dan G. Duda, Rakesh K. Jain, David P. Ryan, Charles S. Fuchs, Michelle Knowles, Eamala Vasudev, Eileen Regan, Susan Sheehan, Alona Muzikansky, Pankaj Bhargava, Nadine Jackson McCleary, Thomas A. Abrams, Jeffrey A. Meyerhardt, Lawrence S. Blaszkowsky, Dushyant V. Sahani, Jeffrey G. Supko, Marek Ancukiewicz, Andrew X. Zhu
Purpose: We conducted a single-arm phase II study of cediranib, a pan-VEGFR tyrosine kinase inhibitor, in patients with advanced hepatocellular carcinoma (HCC).Experimental Design: Patients with histologically confirmed measurable advanced HCC and ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7160077e35660095c7827d46ac4afdae
https://doi.org/10.1158/1078-0432.c.6522066.v1
https://doi.org/10.1158/1078-0432.c.6522066.v1
Autor:
Dan G. Duda, Rakesh K. Jain, David P. Ryan, Charles S. Fuchs, Michelle Knowles, Eamala Vasudev, Eileen Regan, Susan Sheehan, Alona Muzikansky, Pankaj Bhargava, Nadine Jackson McCleary, Thomas A. Abrams, Jeffrey A. Meyerhardt, Lawrence S. Blaszkowsky, Dushyant V. Sahani, Jeffrey G. Supko, Marek Ancukiewicz, Andrew X. Zhu
PDF file - 159K, Supplementary Table S1: Kinetics of plasma biomarkers and circulating progenitor cells (CPCs) at days 1 and/or 14 during the first cycle of daily 30mg cediranib monotherapy in advanced HCC patients. Supplementary Table S2: Analysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231bc451c192c12945b6390a090af423
https://doi.org/10.1158/1078-0432.22450974
https://doi.org/10.1158/1078-0432.22450974
Autor:
Robert L. Fogerty, Michael Aniskiewicz, Todd Hedges, Sean Ryan, Piper Brien, Peggy Beley, Marc Tangredi, Marci Mitchell, Hillary d’Atri, Laura Jansen, Ena Williams, Francine LoRusso, Mark Sevilla, Jennifer Menillo, Deirdre Doyle, Heather Parrott, Susan Sheehan, Richard A. Martinello, Michael Holmes
Publikováno v:
Hospital Topics. 100:69-76
The 2019 SARS-CoV2 virus presented a capacity demand scenario for Yale New Haven Hospital. The response was created with a focus on clinical needs, but was also driven by the unique characteristics of the buildings within our institution. These physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10713094f935e1333846de409fafb0cf
https://doi.org/10.1080/00185868.2021.1926383
https://doi.org/10.1080/00185868.2021.1926383
Autor:
Liu T, Spence E, Raul Castro-Portuguez, George L. Sutphin, Samuel Freitas, Meyers J, Caroline Corban, Susan Sheehan, Shannon Bean, Shuck K, Espejo L, Ron Korstanje, Grant Backer, Dang H
SummaryThe metabolism of tryptophan to nicotinamide adenine dinucleotide (NAD+) through the kynurenine pathway is increasingly linked to aging and age-associated disease. Kynurenine pathway enzymes and metabolites influence a range of molecular proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b067c50607c7295c6ebfce80dc40f9d
https://doi.org/10.1101/2021.06.01.446651
https://doi.org/10.1101/2021.06.01.446651