Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Susan Salamone"'
Autor:
Susan Salamone, Steven Tregay, Brian I. Bliss, Michael P. Trova, Simon Haydar, Joseph Anthony Bilotta, Luis Alicea, Patricia Snider, Matthew P. Rainka, R. Jason Herr, Xiaozhang Zheng, Denise Peace, Thuy Nguyen Duong, Keith D. Barnes, Travis Benanti, Thomas D. Friedrich, Matthew R. Johnson, Mark Bielaska, Yu Hui, John M. Lehman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6613-6617
The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity.
Autor:
Michael P. Trova, Keith D. Barnes, Curt Barford, Travis Benanti, Mark Bielaska, Lori Burry, John M. Lehman, Christine Murphy, Harold O’Grady, Denise Peace, Susan Salamone, Jennifer Smith, Patricia Snider, Joseph Toporowski, Steven Tregay, Alison Wilson, Michael Wyle, Xiaozhang Zheng, Thomas D. Friedrich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6608-6612
The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity.