Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Susan R. Quinn"'
Autor:
Elaine F Kenny, Susan R Quinn, Sarah L Doyle, Paul M Vink, Hans van Eenennaam, Luke A J O'Neill
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e74103 (2013)
B cells signal through both the B cell receptor (BCR) which binds antigens and Toll-like receptors (TLRs) including TLR9 which recognises CpG DNA. Activation of TLR9 synergises with BCR signalling when the BCR and TLR9 co-localise within an auto-phag
Externí odkaz:
https://doaj.org/article/0bf52f45918f491c9dfe57dafbd52529
Autor:
Susan R. Quinn, Graham M. Hughes, Emma C. Teeling, Sébastien J. Puechmaille, Eva M. Palsson-McDermott, Joanna Kacprzyk, Luke A. J. O'Neill
Publikováno v:
Acta Chiropterologica. 19:219-228
Bats are unique among mammals given their ability to fly, apparent tolerance of deadly viruses and extraordinary longevity. We propose that these traits are linked and driven by adaptations of the innate immune system. To explore this hypothesis we c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40926c13dfa37a64c04081fdafc3de6a
https://doi.org/10.3161/15081109acc2017.19.2.001
https://doi.org/10.3161/15081109acc2017.19.2.001
Autor:
Susan R. Quinn, Christine Becker, Dympna J. Connolly, Pier Paolo Pandolfi, Nollaig M. Bourke, Luke A. J. O'Neill, Sinéad C. Corr, Jennifer K. Dowling, Ashley Mansell
Publikováno v:
Journal of Biological Chemistry. 289:6429-6437
The apoptosis-associated speck-like protein containing a caspase-activating recruitment domain (ASC) is an essential component of several inflammasomes, multiprotein complexes that regulate caspase-1 activation and inflammation. We report here an int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231f79939e5cedb6b21173209bf1dd57
https://doi.org/10.1074/jbc.m113.539692
https://doi.org/10.1074/jbc.m113.539692
Autor:
Luke A. J. O'Neill, Susan R. Quinn
Publikováno v:
International Immunology. 23:421-425
Toll-like receptors (TLRs) in the host recognize conserved microbial products and defend against pathogenic attack by initiating an immune response via signalling pathways that lead to an increase in immune and inflammatory gene expression. TLR signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8974de90bce67ffeb547b232bce8bf
https://doi.org/10.1093/intimm/dxr034
https://doi.org/10.1093/intimm/dxr034
Autor:
Susan R. Quinn, Peter J. Murray, Claire E. McCoy, Luke A. J. O'Neill, Sarah L. Doyle, Frederick J. Sheedy, Joseph E. Qualls
Publikováno v:
Journal of Biological Chemistry. 285:20492-20498
IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes, which are induced by Toll-like receptor (TLR) signaling. In this study, we have examined whether modulation of microRNAs plays a role in the inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a581fc71ed9a97a1a0ac1efd58f46578
https://doi.org/10.1074/jbc.m110.102111
https://doi.org/10.1074/jbc.m110.102111
Autor:
Luke A. J. O'Neill, Clary B. Clish, Mario A.R. Lauterbach, Susan R. Quinn, Frederick J. Sheedy, Anne M. Curtis, Daniel G.W. Johnston, Joseph Keane, Gautam Goel, Craig J. Thomas, Raquel Domingo-Fernandez, William J. Israelsen, Matthew G. Vander Heiden, Eva M. Palsson-McDermott, Mirjam W.M. van den Bosch, Laura E. Gleeson, Ramnik J. Xavier, Jian-kang Jiang
SummaryMacrophages activated by the TLR4 agonist LPS undergo dramatic changes in their metabolic activity. We here show that LPS induces expression of the key metabolic regulator Pyruvate Kinase M2 (PKM2). Activation of PKM2 using two well-characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a098b127ed46129ab7464d688c98fbc0
https://europepmc.org/articles/PMC5198835/
https://europepmc.org/articles/PMC5198835/
Autor:
Susan R, Quinn, Luke A, O'Neill
Publikováno v:
Current topics in microbiology and immunology. 380
Recent studies have shown an important interplay between Interleukin 10 (IL-10) and microRNAs. IL-10 can be directly post-transcriptionally regulated by several microRNA, including miR-106a, miR-4661, miR-98, miR-27, let7 and miR-1423p/5p. miRNA targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e11e3666fc54875bac5640baf0c16bd7
https://pubmed.ncbi.nlm.nih.gov/25004817
https://pubmed.ncbi.nlm.nih.gov/25004817
Publikováno v:
Public Personnel Management. 26:529-533
In September 1995, the city manager of San Marino decided to take a new approach to upcoming negotiations between management and the firefighters association. In the past, relationships had been, at a minimum strained, and at times, strongly adversar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba8673a7d044f1acb327398444dd78d1
https://doi.org/10.1177/009102609702600409
https://doi.org/10.1177/009102609702600409
Autor:
Michael P. Gantier, Niamh E. Mangan, Paul J. Hertzog, Luke A. J. O'Neill, Brian E. Caffrey, Claire E. McCoy, Bryan R.G. Williams, Susan R. Quinn
Publikováno v:
The Journal of biological chemistry. 289(7)
MicroRNA-155 (miR-155) is highly expressed in many cancers such as B cell lymphomas and myeloid leukemia and inflammatory disorders such as rheumatoid arthritis, atopic dermatitis, and multiple sclerosis. The role of miR-155 as both a promoter of inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2d664b5150fa50a9715810490fedc1
https://pubmed.ncbi.nlm.nih.gov/24362029
https://pubmed.ncbi.nlm.nih.gov/24362029
Autor:
Paul N. Moynagh, Anne F. McGettrick, Luke A. J. O'Neill, Brian E. Caffrey, Jorge Caamano, Kari Ann Shirey, Susan R. Quinn, Sarah L. Doyle, Siobhan Gargan, Stefanie N. Vogel, Elaine F. Kenny, Susan Carpenter
Publikováno v:
The Journal of biological chemistry. 288(35)
In this study we describe a previously unreported function for NFκB2, an NFκB family transcription factor, in antiviral immunity. NFκB2 is induced in response to poly(I:C), a mimic of viral dsRNA. Poly(I:C), acting via TLR3, induces p52-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc994e885a5aea178eeb20ddd41ed43
https://pubmed.ncbi.nlm.nih.gov/23873932
https://pubmed.ncbi.nlm.nih.gov/23873932