Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Susan R Watson"'
Autor:
Brenda Y Han, Shuang Wu, Chuan-Sheng Foo, Robert M Horton, Craig N Jenne, Susan R Watson, Belinda Whittle, Chris C Goodnow, Jason G Cyster
Publikováno v:
eLife, Vol 3 (2014)
The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger prot
Externí odkaz:
https://doaj.org/article/ddad725609d84747b5161b6b5274b9bf
Autor:
John A Corbin, Vinay Bhaskar, Ira D Goldfine, Daniel H Bedinger, Angela Lau, Kristen Michelson, Lisa M Gross, Betty A Maddux, Hua F Kuan, Catarina Tran, Llewelyn Lao, Masahisa Handa, Susan R Watson, Ajay J Narasimha, Shirley Zhu, Raphael Levy, Lynn Webster, Sujeewa D Wijesuriya, Naichi Liu, Xiaorong Wu, David Chemla-Vogel, Steve R Lee, Steve Wong, Diane Wilcock, Mark L White
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88684 (2014)
Previously we reported studies of XMetA, an agonist antibody to the insulin receptor (INSR). We have now utilized phage display to identify XMetS, a novel monoclonal antibody to the INSR. Biophysical studies demonstrated that XMetS bound to the human
Externí odkaz:
https://doaj.org/article/ec07dde7e6df4a3f9009b736ea547f18
Autor:
Robert Brink, David Zahra, Jeanette E. Villanueva, Benjamin T. Porebski, Garry P. Nolan, Murray P. Cox, Carla M. Roots, Claudia Loetsch, Cecile King, Paul Z. Benitez-Aguirre, Jia Tang, Belinda Whittle, Juliana Teo, Joanna Warren, Wendy Sandoval, Marcel E. Dinger, Elisabeth K. Malle, Christopher C. Goodnow, Geeta Chaudhri, Velimir Gayevskiy, Ingrid E. Wertz, Jin Yan Yap, John B. Ziegler, Yogesh Jeelall, Keisuke Horikawa, Colin J. Jackson, Stacey N. Walters, Daniele Cultrone, Daniel Christ, Frank Schmitz, Nathan W. Zammit, Shane T. Grey, Melanie Wong, David B. Langley, Craig N. Jenne, Owen M. Siggs, Tim Wiltshire, Anselm Enders, Lewis L. Lanier, Mark J. Cowley, Matthew H. Spitzer, Wilson Phung, Stuart G. Tangye, Peter D. Mabbitt, Derek W. Abbott, Susan R. Watson, Benjamin E. Clifton, Stephen R. Daley, Alan Aderem, Paul Gray, Ashley M. Buckle, Gunasegaran Karupiah, Michiko Yamada, Edward M. Bertram, Amanda J. Russell, Maria E. Craig
Publikováno v:
Nature Immunology. 20:1299-1310
Resisting and tolerating microbes are alternative strategies to survive infection, but little is known about the evolutionary mechanisms controlling this balance. Here genomic analyses of anatomically modern humans, extinct Denisovan hominins and mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::515ef1e9292a4a527c9a1195b3848013
https://doi.org/10.1038/s41590-019-0492-0
https://doi.org/10.1038/s41590-019-0492-0
Autor:
Susan R. Watson, Stephen R. Daley, Edward M. Bertram, David Zahra, Joanna Warren, Stacey N. Walters, Ashley M. Buckle, Claudia Loetsch, Cecile King, Yogesh Jeelall, Keisuke Horikawa, Colin J. Jackson, Shane T. Grey, Anselm Enders, Paul Gray, Benjamin T. Porebski, Craig N. Jenne, Marcel E. Dinger, Jeanette E. Villanueva, Amanda J. Russell, Owen M. Siggs, Michiko Yamada, Derek W. Abbott, David B. Langley, Maria E. Craig, Matthew H. Spitzer, Melanie Wong, Ingrid E. Wertz, Mark J. Cowley, John B. Ziegler, Tim Wiltshire, Paul Z. Benitez-Aguirre, Christopher C. Goodnow, Daniel Christ, Garry P. Nolan, Murray P. Cox, Benjamin E. Clifton, Daniele Cultrone, Gunasegaran Karupiah, Alan Aderem, Robert Brink, Nathan W. Zammit, Carla M. Roots, Lewis L. Lanier, Juliana Teo, Elisabeth K. Malle, Geeta Chaudhri, Peter D. Mabbitt, Belinda Whittle, Frank Schmitz, Velimir Gayevskiy, Wilson Phung
Publikováno v:
Nature Immunology
bioRxiv
bioRxiv
Resisting or tolerating microbes are alternative strategies to survive infection, but little is known about the evolutionary mechanisms controlling this balance. Here, genomic analyses of anatomically modern humans, extinct Denisovan hominins, and mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f197ac2554c943341a13dcc627644f
https://doi.org/10.1101/589507
https://doi.org/10.1101/589507
Autor:
Nathan W, Zammit, Owen M, Siggs, Paul E, Gray, Keisuke, Horikawa, David B, Langley, Stacey N, Walters, Stephen R, Daley, Claudia, Loetsch, Joanna, Warren, Jin Yan, Yap, Daniele, Cultrone, Amanda, Russell, Elisabeth K, Malle, Jeanette E, Villanueva, Mark J, Cowley, Velimir, Gayevskiy, Marcel E, Dinger, Robert, Brink, David, Zahra, Geeta, Chaudhri, Gunasegaran, Karupiah, Belinda, Whittle, Carla, Roots, Edward, Bertram, Michiko, Yamada, Yogesh, Jeelall, Anselm, Enders, Benjamin E, Clifton, Peter D, Mabbitt, Colin J, Jackson, Susan R, Watson, Craig N, Jenne, Lewis L, Lanier, Tim, Wiltshire, Matthew H, Spitzer, Garry P, Nolan, Frank, Schmitz, Alan, Aderem, Benjamin T, Porebski, Ashley M, Buckle, Derek W, Abbott, John B, Ziegler, Maria E, Craig, Paul, Benitez-Aguirre, Juliana, Teo, Stuart G, Tangye, Cecile, King, Melanie, Wong, Murray P, Cox, Wilson, Phung, Jia, Tang, Wendy, Sandoval, Ingrid E, Wertz, Daniel, Christ, Christopher C, Goodnow, Shane T, Grey
Publikováno v:
Nature immunology. 20(10)
Resisting and tolerating microbes are alternative strategies to survive infection, but little is known about the evolutionary mechanisms controlling this balance. Here genomic analyses of anatomically modern humans, extinct Denisovan hominins and mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d716d3e5402ee7d9b9b572913f8a8831
https://pubmed.ncbi.nlm.nih.gov/32571487
https://pubmed.ncbi.nlm.nih.gov/32571487
Autor:
Susan R. Watson, Thomas D. Duensing
Publikováno v:
Cold Spring Harbor protocols. 2018(1)
This simple protocol tests antibody binding to target antigens on the surface of cells. This assay is powerful because negative controls are built into each well of the screening plates. It can be used to screen crude supernatants from hybridomas, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3b2092b7db0f9d7bf390b591c249a8
https://pubmed.ncbi.nlm.nih.gov/29295900
https://pubmed.ncbi.nlm.nih.gov/29295900
Autor:
Susan R. Watson, Thomas D. Duensing
Publikováno v:
Cold Spring Harbor protocols. 2018(1)
A useful feature of therapeutic antibodies is the ability to kill the cells to which they bind. Antibodies are capable of mediating cell killing in a variety of ways. Apoptosis, complement-mediated mechanisms, and antibody-dependent cellular cytotoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6f038a7f39468e1fcbfaa080cac37a
https://pubmed.ncbi.nlm.nih.gov/29295901
https://pubmed.ncbi.nlm.nih.gov/29295901
Autor:
Shirley Zhu, David Chemla-Vogel, Ajay J. Narasimha, Lynn Webster, Angela Lau, Sujeewa D. Wijesuriya, Diane Wilcock, Raphael Levy, Hassan Issafras, Paul Rubin, Hua F. Kuan, Catarina Tran, Daniel Bedinger, Vinay Bhaskar, Ira D. Goldfine, John Corbin, Xiaorong Wu, Susan R. Watson, Llewelyn Lao, Naichi Liu, Kristen Michelson, Masahisa Handa, Lisa Gross, Steve R. Lee, Steve Wong, Betty A. Maddux, Mark L. White
Publikováno v:
mAbs
Novel therapies are needed for the treatment of hypoglycemia resulting from both endogenous and exogenous hyperinsulinema. To provide a potential new treatment option, we identified XMetD, an allosteric monoclonal antibody to the insulin receptor (IN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a981aef464820bb0d1ce04c389f12b84
https://doi.org/10.4161/mabs.26871
https://doi.org/10.4161/mabs.26871
Autor:
David Chemla-Vogel, Hua-Feng Kuan, Fangjiu Zhang, John W. Beaber, Betty Huang, Pamela Toy, Isaac Rondon, Lauren Schwimmer, Eric M. Tam, Hoa Giang, Daniel Bedinger, David J. Bohmann, Susan R. Watson, Nithin B. Reddy, Robyn Cotter, Francis V. Dy
Publikováno v:
Journal of Immunological Methods. 391(1-2):60-71
Phage display antibody libraries have a proven track record for the discovery of therapeutic human antibodies, increasing the demand for large and diverse phage antibody libraries for the discovery of new therapeutics. We have constructed naïve anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee701668f29d54482ebfabaebcca53c4
Autor:
Masahisa Handa, Diane Wilcock, Ajay J. Narasimha, Raphael Levy, Lynn Webster, Sujeewa D. Wijesuriya, John Corbin, Steve R. Lee, Hua F. Kuan, Daniel Bedinger, Xiaorong Wu, Vinay Bhaskar, Shirley Zhu, David Chemla-Vogel, Lisa Gross, Steve Wong, Mark L. White, Susan R. Watson, Naichi Liu, Catarina Tran, Ira D. Goldfine, Angela Lau, Betty A. Maddux
Publikováno v:
Diabetes
Many patients with diabetes mellitus (both type 1 and type 2) require therapy to maintain normal fasting glucose levels. To develop a novel treatment for these individuals, we used phage display technology to target the insulin receptor (INSR) comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de204c14d0a31a17006c9725a778704b
http://europepmc.org/articles/PMC3331746
http://europepmc.org/articles/PMC3331746