Výsledky vyhledávání - "Susan Quinn DeJoy"

Design and Synthesis of Novel Diaminoquinazolines with in Vivo Efficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway Inhibition

Autor: Osvaldo Dos Santos, Inder Chaudhary, Kim Arndt, Judy Lucas, Veronica Diesl, Natasja Brooijmans, Aranapakam Mudumbai Venkatesan, Semiramis Ayral-Kaloustian, Kevin J. Curran, Max Follettie, Susan Quinn Dejoy, Lei Chen, Efren Guillermo Delos Santos, Christoph Martin Dehnhardt, Zecheng Chen, Rosanne Petersen, Tarek S. Mansour, Yi Geng

Publikováno v: Journal of Medicinal Chemistry. 53:897-910

We are introducing a novel series of 2,4-diaminoquinazolines as beta-catenin/Tcf4 inhibitors which were identified by ligand-based design. Here we elucidate the SAR of this series and explain how we were able to improve key molecular properties such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e05daac3bd05bde9e23c93510e3ae1
https://doi.org/10.1021/jm901370m

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Effect of CL 184,005, a Platelet-Activating Factor Antagonist in a Murine Model of Staphylococcus aureus-Induced Gram-Positive Sepsis

Autor: Arnold L. Oronsky, Susan Quinn DeJoy, Walter C. Pickett, Lawrence W. Torley, Michael M. Wick, Suresh S. Kerwar, Robert Jeyaseelan, Allan Wissner

Publikováno v: Journal of Infectious Diseases. 169:150-156

Experiments using a murine model of heat-killed Staphylococcus aureus-induced gram-positive bacterial sepsis indicate that the lethal bacterial effects can be prevented if mice are pretreated with CL 184,005, a platelet-activating factor (PAF) antago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e45baec17e008af3b6a558364dc535
https://doi.org/10.1093/infdis/169.1.150

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Control of mammary tumor differentiation by SKI-606 (bosutinib)

Publikováno v: Oncogene, vol 30, iss 3
Oncogene

C-Src is infrequently mutated in human cancers but it mediates oncogenic signals of many activated growth factor receptors and thus remains a key target for cancer therapy. However, the broad function of Src in many cell types and processes requires

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b6510a99b83af8e928efa96e6f6b0b
https://escholarship.org/uc/item/56x3n8r2

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Preclinical studies with platelet-activating factor antagonists in models of septic shock

Autor: Susan Quinn DeJoy, Michael M. Wick, Suresh S. Kerwar, Arnold L. Oronsky

Publikováno v: International Journal of Antimicrobial Agents. 3:175-186

Since the isolation and elucidation of the structure of platelet-activating factor (PAF) in the late 1970's, several preclinical studies have suggested that PAF is a key mediator of septic shock induced in animals by either endotoxin or by Gram-negat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fcc60ccf25346af7121d4daad3baa0
https://doi.org/10.1016/0924-8579(93)90011-s

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Pluronic F 127 liquid sensitizes mice to low doses of Escherichia coli lipopolysaccharide

Autor: James Joseph Gibbons, Susan Quinn Dejoy, Narendra R. Desai, Lawrence Wayne Torley, Walter C. Pickett, S. S. Kerwar, Arnold L. Oronsky

Publikováno v: Critical Care Medicine. 20:1448-1453

Background and methods In murine models of endotoxemia, large amounts of lipopolysaccharide have to be administered to induce mortality. If mice are pretreated with D-galactosamine, the amount of lipopolysaccharide required to induce mortality is sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e42527732e7ba313fcdea3bee41fe5
https://doi.org/10.1097/00003246-199210000-00014

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Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis

Autor: Robert E. Schaub, Lawrence W. Torley, Arnold L. Oronsky, M L Carroll, Allan Wissner, Susan Quinn DeJoy, Suresh S. Kerwar, Constance Kohler, Walter C. Pickett

Publikováno v: Antimicrobial Agents and Chemotherapy. 36:1971-1977

The effect of CL 184,005, a potent and specific platelet-activating factor antagonist, has been examined in a variety of animal models relevant to gram-negative bacterial sepsis. Pretreatment of mice with CL 184,005 protected them from the lethal eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864803afec5fbaa81bc9e35a3fcfbdca
https://doi.org/10.1128/aac.36.9.1971

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Studies on the homing of Mycobacterium-sensitized T lymphocytes to the synovium during passive adjuvant arthritis

Autor: Arnold L. Oronsky, Kim M. Ferguson-Chanowitz, Suresh S. Kerwar, Susan Quinn DeJoy, John B. Zabriskie

Publikováno v: Cellular Immunology. 130:195-203

The migration of intravenously administered adjuvant sensitized T lymphocytes to the knee synovium of recipient rats undergoing passive adjuvant arthritis has been followed. Using fluorescein isothiocyanate (FITC)-labeled adjuvant-sensitized T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e149c7d37a8c2d5f830929ed835b7e11
https://doi.org/10.1016/0008-8749(90)90173-o

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Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2

Autor: Kenneth H. Grabstein, Robert Jeyaseelan, Michael M. Wick, Susan Quinn Dejoy, Lawrence Wayne Torley, June Eisenmann, William E. Munger, Ray Paxton, S. S. Kerwar, Tom Cox

Publikováno v: Cellular immunology. 165(2)

Interleukin-15 is a new cytokine that stimulates the proliferation of T cells and other cells of the immune system. Some of the biological properties of interleukin-15 overlap that of interleukin-2. Using murine models, the present studies have shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69d0617d691c50946aa50307e0642e1
https://pubmed.ncbi.nlm.nih.gov/7553894

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