Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Susan Quinn DeJoy"'
Autor:
Osvaldo Dos Santos, Inder Chaudhary, Kim Arndt, Judy Lucas, Veronica Diesl, Natasja Brooijmans, Aranapakam Mudumbai Venkatesan, Semiramis Ayral-Kaloustian, Kevin J. Curran, Max Follettie, Susan Quinn Dejoy, Lei Chen, Efren Guillermo Delos Santos, Christoph Martin Dehnhardt, Zecheng Chen, Rosanne Petersen, Tarek S. Mansour, Yi Geng
Publikováno v:
Journal of Medicinal Chemistry. 53:897-910
We are introducing a novel series of 2,4-diaminoquinazolines as beta-catenin/Tcf4 inhibitors which were identified by ligand-based design. Here we elucidate the SAR of this series and explain how we were able to improve key molecular properties such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e05daac3bd05bde9e23c93510e3ae1
https://doi.org/10.1021/jm901370m
https://doi.org/10.1021/jm901370m
Autor:
Arnold L. Oronsky, Susan Quinn DeJoy, Walter C. Pickett, Lawrence W. Torley, Michael M. Wick, Suresh S. Kerwar, Robert Jeyaseelan, Allan Wissner
Publikováno v:
Journal of Infectious Diseases. 169:150-156
Experiments using a murine model of heat-killed Staphylococcus aureus-induced gram-positive bacterial sepsis indicate that the lethal bacterial effects can be prevented if mice are pretreated with CL 184,005, a platelet-activating factor (PAF) antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e45baec17e008af3b6a558364dc535
https://doi.org/10.1093/infdis/169.1.150
https://doi.org/10.1093/infdis/169.1.150
Autor:
Jonathon Golas, Miriam Wankell, Robert A. Rollins, Junko Sawada, Lesley G. Ellies, Lionel Hebbard, Grace Cecena, Adriana Charbono, Veronica Diesl, Robert D. Cardiff, Masanobu Komatsu, Susan Quinn Dejoy, Rebecca E. Jimenez, Lei Chen, Edward Rosfjord, Roy Williams, Kim Arndt, Robert G. Oshima, Frank Boschelli, Maxmillian Follettie
Publikováno v:
Oncogene, vol 30, iss 3
Oncogene
Oncogene
C-Src is infrequently mutated in human cancers but it mediates oncogenic signals of many activated growth factor receptors and thus remains a key target for cancer therapy. However, the broad function of Src in many cell types and processes requires
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b6510a99b83af8e928efa96e6f6b0b
https://escholarship.org/uc/item/56x3n8r2
https://escholarship.org/uc/item/56x3n8r2
Publikováno v:
International Journal of Antimicrobial Agents. 3:175-186
Since the isolation and elucidation of the structure of platelet-activating factor (PAF) in the late 1970's, several preclinical studies have suggested that PAF is a key mediator of septic shock induced in animals by either endotoxin or by Gram-negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fcc60ccf25346af7121d4daad3baa0
https://doi.org/10.1016/0924-8579(93)90011-s
https://doi.org/10.1016/0924-8579(93)90011-s
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f8112487ec57439952bebaeed55de49
https://doi.org/10.1002/chin.199520224
https://doi.org/10.1002/chin.199520224
Autor:
James Joseph Gibbons, Susan Quinn Dejoy, Narendra R. Desai, Lawrence Wayne Torley, Walter C. Pickett, S. S. Kerwar, Arnold L. Oronsky
Publikováno v:
Critical Care Medicine. 20:1448-1453
Background and methods In murine models of endotoxemia, large amounts of lipopolysaccharide have to be administered to induce mortality. If mice are pretreated with D-galactosamine, the amount of lipopolysaccharide required to induce mortality is sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e42527732e7ba313fcdea3bee41fe5
https://doi.org/10.1097/00003246-199210000-00014
https://doi.org/10.1097/00003246-199210000-00014
Autor:
Robert E. Schaub, Lawrence W. Torley, Arnold L. Oronsky, M L Carroll, Allan Wissner, Susan Quinn DeJoy, Suresh S. Kerwar, Constance Kohler, Walter C. Pickett
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:1971-1977
The effect of CL 184,005, a potent and specific platelet-activating factor antagonist, has been examined in a variety of animal models relevant to gram-negative bacterial sepsis. Pretreatment of mice with CL 184,005 protected them from the lethal eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864803afec5fbaa81bc9e35a3fcfbdca
https://doi.org/10.1128/aac.36.9.1971
https://doi.org/10.1128/aac.36.9.1971
Autor:
Arnold L. Oronsky, Kim M. Ferguson-Chanowitz, Suresh S. Kerwar, Susan Quinn DeJoy, John B. Zabriskie
Publikováno v:
Cellular Immunology. 130:195-203
The migration of intravenously administered adjuvant sensitized T lymphocytes to the knee synovium of recipient rats undergoing passive adjuvant arthritis has been followed. Using fluorescein isothiocyanate (FITC)-labeled adjuvant-sensitized T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e149c7d37a8c2d5f830929ed835b7e11
https://doi.org/10.1016/0008-8749(90)90173-o
https://doi.org/10.1016/0008-8749(90)90173-o
Publikováno v:
The Journal of Organic Chemistry. 59:6850-6852
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad796603423e2e04f5af2c11a909c3e8
https://doi.org/10.1021/jo00101a056
https://doi.org/10.1021/jo00101a056
Autor:
Kenneth H. Grabstein, Robert Jeyaseelan, Michael M. Wick, Susan Quinn Dejoy, Lawrence Wayne Torley, June Eisenmann, William E. Munger, Ray Paxton, S. S. Kerwar, Tom Cox
Publikováno v:
Cellular immunology. 165(2)
Interleukin-15 is a new cytokine that stimulates the proliferation of T cells and other cells of the immune system. Some of the biological properties of interleukin-15 overlap that of interleukin-2. Using murine models, the present studies have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69d0617d691c50946aa50307e0642e1
https://pubmed.ncbi.nlm.nih.gov/7553894
https://pubmed.ncbi.nlm.nih.gov/7553894