Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Susan P. Lees-Miller"'
Autor:
Frantisek Filandr, Vladimir Sarpe, Shaunak Raval, D. Alex Crowder, Morgan F. Khan, Pauline Douglas, Stephen Coales, Rosa Viner, Aleem Syed, John A. Tainer, Susan P. Lees-Miller, David C. Schriemer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract We present a hydrogen/deuterium exchange workflow coupled to tandem mass spectrometry (HX-MS2) that supports the acquisition of peptide fragment ions alongside their peptide precursors. The approach enables true auto-curation of HX data by m
Externí odkaz:
https://doaj.org/article/8c900839ad1c4b10a419586ee7d79785
Autor:
Frantisek Filandr, Vladimir Sarpe, Shaunak Raval, D. Alex Crowder, Morgan F. Khan, Pauline Douglas, Stephen Coales, Rosa Viner, Aleem Syed, John A. Tainer, Susan P. Lees-Miller, David C. Schriemer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/165f5b3a8f494e12ab6cbfdea6535412
Autor:
Simon R. Walker, Ramy Abdelsalam, Sunita Ghosh, Julie Livingstone, Nallasivam Palanisamy, Paul C. Boutros, Steven M. Yip, Susan P. Lees-Miller, Tarek A. Bismar
Publikováno v:
European Urology Open Science, Vol 29, Iss , Pp 93-101 (2021)
Background: Ataxia Telangiectasia Mutated (ATM) serine/threonine protein kinase is a known tumor suppressor, involved in DNA damage repair. It has prognostic and predictive therapeutic implications and is associated with aggressive prostate cancer (P
Externí odkaz:
https://doaj.org/article/6ee9b4c07d23483389622da0e4347712
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The DNA damage response (DDR) is an organized network of multiple interwoven components evolved to repair damaged DNA and maintain genome fidelity. Conceptually the DDR includes damage sensors, transducer kinases, and effectors to maintain genomic st
Externí odkaz:
https://doaj.org/article/e99c0ec815e84b5bad862b10faf3874c
Autor:
Theodora A. Koulis, Elizabeth N. Kornaga, Robyn Banerjee, Tien Phan, Prafull Ghatage, Anthony M. Magliocco, Susan P. Lees-Miller, Corinne M. Doll
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 4, Iss C, Pp 51-56 (2017)
Introduction: Anemia has long been associated with poor prognosis in patients with cervical cancer. Recently, additional hematologic parameters have emerged as potential indicators of worse outcome in this patient group. In a cohort of cervical cance
Externí odkaz:
https://doaj.org/article/de7ebd94241040388c5e0fe115c6c890
Publikováno v:
Translational Oncology, Vol 10, Iss 2, Pp 190-196 (2017)
The ataxia telangiectasia mutated (ATM) protein kinase plays a central role in the cellular response to DNA damage. Loss or inactivation of both copies of the ATM gene (ATM) leads to ataxia telangiectasia, a devastating childhood condition characteri
Externí odkaz:
https://doaj.org/article/b3727121b9cb4114a9991ef422822bdb
Autor:
Nicholas R. Jette, Mehul Kumar, Suraj Radhamani, Greydon Arthur, Siddhartha Goutam, Steven Yip, Michael Kolinsky, Gareth J. Williams, Pinaki Bose, Susan P. Lees-Miller
Publikováno v:
Cancers, Vol 12, Iss 3, p 687 (2020)
Poly-ADP ribose polymerase (PARP) inhibitors are currently used in the treatment of several cancers carrying mutations in the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2, with many more potential applications under study and in cli
Externí odkaz:
https://doaj.org/article/a9c064e50c564fcc891dc9fca9dc689f
Autor:
Pauline Douglas, Ruiqiong Ye, Laura Trinkle‑Mulcahy, Jessica A. Neal, Veerle De Wever, Nick A. Morrice, Katheryn Meek, Susan P. Lees‑Miller
Publikováno v:
Bioscience Reports, Vol 34, Iss 3, p e00113 (2014)
The protein kinase activity of the DNA-PKcs (DNA-dependent protein kinase catalytic subunit) and its autophosphorylation are critical for DBS (DNA double-strand break) repair via NHEJ (non-homologous end-joining). Recent studies have shown that deple
Externí odkaz:
https://doaj.org/article/fc06bf56cbc94c20abed4a3a060d32c0
Autor:
Siyu Chen, Alex Vogt, Linda Lee, Tasmin Naila, Ryan McKeown, Alan E Tomkinson, Susan P Lees-Miller, Yuan He
Publikováno v:
Science Advances. 9
DNA double-strand breaks (DSBs), one of the most cytotoxic forms of DNA damage, can be repaired by the tightly regulated nonhomologous end joining (NHEJ) machinery (Stinson and Loparo and Zhao et al. ). Core NHEJ factors form an initial long-range (L
Autor:
Puri Fortes, Susan P. Lees-Miller, Oscar Llorca, Fernando Moreno-Herrero, Gareth Williams, Bruno Sangro, Jessica Zucman-Rossi, Stefano Caruso, Linda Lee, Raquel Arribas-Bosacoma, Laura Prats-Mari, Christopher McCoy, Clara Aicart-Ramos, Sara de Bragança, Eva M. Martín-Cuevas, Nerea Razquin, Ángel Rivera-Calzada, Mikel Marín-Baquero, Juan P. Unfried
Long noncoding RNAs (lncRNA) are emerging as key players in cancer as parts of poorly understood molecular mechanisms. Here, we investigated lncRNAs that play a role in hepatocellular carcinoma (HCC) and identified NIHCOLE, a novel lncRNA induced in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddc8d809a7727844f6b3daa38980da84
https://doi.org/10.1158/0008-5472.c.6512958.v1
https://doi.org/10.1158/0008-5472.c.6512958.v1