Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Susan P. Hawkes"'
Autor:
Narendra S. Kishnani, Mike Hutton, Dylan R. Edwards, Susan P. Hawkes, Gillian Murphy, Karen M.-L. Yeow
Publikováno v:
Matrix Biology. 21:75-88
The TIMP family of matrix metalloproteinase inhibitors consists of four members, of which TIMP-1, -2 and -4 are secreted, freely diffusible proteins, whereas TIMP-3 is ECM-associated. Mutations in the TIMP3 gene have been linked to Sorsby's fundus dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba08ef4892b4ba03287e0425853df71
https://doi.org/10.1016/s0945-053x(01)00180-9
https://doi.org/10.1016/s0945-053x(01)00180-9
Autor:
James P. Quigley, Elizabeth Hahn-Dantona, Brian K. Weaver, Ling-Hui Li, Susan P. Hawkes, Ronald T. Aimes
Publikováno v:
Journal of Cellular Physiology. 174:342-352
Rous sarcoma virus-transformed chicken embryo fibroblasts (RSVCEF), when compared to normal CEF, produce elevated levels of matrix metalloproteinase-2 (MMP-2) that exists in a form free of complexed tissue inhibitor of metalloproteinase-2 (TIMP-2). I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a04dc65d2835fe2e7457a137335dc10
https://doi.org/10.1002/(sici)1097-4652(199803)174:3<342::aid-jcp8>3.0.co
https://doi.org/10.1002/(sici)1097-4652(199803)174:3<342::aid-jcp8>3.0.co
Autor:
Kevin J. Leco, Suneel S. Apte, Gary T. Taniguchi, Gilbert A. Schultz, Rama Khokha, Dylan R. Edwards, Susan P. Hawkes
Publikováno v:
FEBS Letters. 401:213-217
We have isolated cDNA clones corresponding to a new member of the murine tissue inhibitor of metalloproteinase (TIMP) family, designated Timp-4. The nucleotide sequence predicts a protein of 22,609 Da that contains the characteristic 12 cysteine TIMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::723b9407ae5b5ddbf88ffd9df53abe10
https://doi.org/10.1016/s0014-5793(96)01474-3
https://doi.org/10.1016/s0014-5793(96)01474-3
Autor:
Michael T. McMaster, Thien Khai H Vu, Mary Janatpour, Susan J. Fisher, Hongxia Li, Susan P. Hawkes, Elizabeth C. Bullen, Kathryn E. Bass, Eric W. Howard
Publikováno v:
Developmental Genetics. 21:61-67
Surprisingly, a successful human pregnancy requires cells from the fetal portion of the placenta (cytotrophoblasts) to adopt tumor-like properties. Cytotrophoblasts attach the conceptus to the endometrium by invading the uterus, and they initiate blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7be71b740b8e886b3c7dbc526742c1a0
https://doi.org/10.1002/(sici)1520-6408(1997)21:1<61::aid-dvg7>3.0.co
https://doi.org/10.1002/(sici)1520-6408(1997)21:1<61::aid-dvg7>3.0.co
Autor:
Elizabeth Hansell, Ole Behrendtsen, Caroline M. Alexander, Susan P. Hawkes, Zena Werb, Nerendra S. Kishnani, Margaret L. Flannery
Publikováno v:
Development. 122:1723-1736
Gelatinase B, a matrix metalloproteinase (MMP) of high specific activity, is highly expressed and activated by mouse blastocysts in culture, and inhibition of this enzyme activity inhibits lysis of extracellular matrix (Behrendtsen, O., Alexander, C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c24d3abdb5db5116fb7c3f92532410
https://doi.org/10.1242/dev.122.6.1723
https://doi.org/10.1242/dev.122.6.1723
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 622
Zymography is the electrophoretic separation of proteins through a polyacrylamide gel containing a proteolytic substrate. After denaturing (but nonreducing) electrophoresis, proteins are renatured and incubated in an appropriate buffer for proteolyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0de44a869cdfcd05337650c4eb83d2ab
https://pubmed.ncbi.nlm.nih.gov/20135288
https://pubmed.ncbi.nlm.nih.gov/20135288
Role of the 21-kDa protein TIMP-3 in oncogenic transformation of cultured chicken embryo fibroblasts
Autor:
Susan P. Hawkes, Te-Tuan Yang
Publikováno v:
Proceedings of the National Academy of Sciences. 89:10676-10680
The 21-kDa protein is an extracellular matrix (ECM) component whose synthesis is stimulated transiently during oncogenic transformation of chicken embryo fibroblasts (CEF) or after treatment of normal cells with the tumor promoter phorbol 12-myristat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d665964a9744b5e09ce2a2b88ed99b4
https://doi.org/10.1073/pnas.89.22.10676
https://doi.org/10.1073/pnas.89.22.10676
Publikováno v:
Journal of Biological Chemistry. 267:17321-17326
We report cDNA cloning and primary structure of a new metalloproteinase inhibitor (ChIMP-3) produced by chicken embryo fibroblasts. ChIMP-3, formerly called the 21-kDa protein, is one of five ChIMPs (Chicken Inhibitor of MetalloProteinases). In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f09786d5c25fbd477df36c1fab9817ee
https://doi.org/10.1016/s0021-9258(18)41928-x
https://doi.org/10.1016/s0021-9258(18)41928-x
Publikováno v:
Journal of Biological Chemistry. 266:449-454
We report the electrophoretic purification and characterization of the 21-kDa protein, an extracellular matrix component synthesized during the early stages of transformation of chicken embryo fibroblasts infected with Rous sarcoma virus (Blenis, J.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d48ebfce0ee4fdfcf4e741e744398f1c
https://doi.org/10.1016/s0021-9258(18)52455-8
https://doi.org/10.1016/s0021-9258(18)52455-8
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology. 14(6)
We have identified and characterized a novel human tissue inhibitor of metalloproteinase (TIMP). It is found exclusively in the extracellular matrix of a large number of cultured human cells, including: primary embryonal kidney (293), neuroblastoma (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3629b7ba92c5b429f4f426d56a1cbcdb
https://pubmed.ncbi.nlm.nih.gov/7795886
https://pubmed.ncbi.nlm.nih.gov/7795886