Výsledky vyhledávání - "Susan P Sambol"

Akademický článek

Absence of toxin gene transfer from Clostridioides difficile strain 630Δerm to nontoxigenic C. difficile strain NTCD-M3r in filter mating experiments.

Autor: Susan P Sambol, Stuart Johnson, Adam Cheknis, Dale N Gerding

Publikováno v: PLoS ONE, Vol 17, Iss 6, p e0270119 (2022)

Nontoxigenic Clostridioides difficile strain M3 (NTCD-M3) protects hamsters and humans against C. difficile infection. Transfer in vitro of the pathogenicity locus (PaLoc) to nontoxigenic strain CD37 has been reported. We repeated these conjugations

Externí odkaz: https://doaj.org/article/43c66f3c0a944fbf884c60c8136d52e9

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Akademický článek

Unique Clindamycin-Resistant Clostridioides difficile Strain Related to Fluoroquinolone-Resistant Epidemic BI/RT027 Strain

Autor: Andrew M. Skinner, Laurica Petrella, Farida Siddiqui, Susan P. Sambol, Christopher A. Gulvik, Dale N. Gerding, Curtis J. Donskey, Stuart Johnson

Publikováno v: Emerging Infectious Diseases, Vol 26, Iss 2, Pp 247-254 (2020)

During a surveillance study of patients in a long-term care facility and the affiliated acute care hospital in the United States, we identified a Clostridioides difficile strain related to the epidemic PCR ribotype (RT) 027 strain associated with hos

Externí odkaz: https://doaj.org/article/945053626e5949daad101134aa64833f

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Effective Colonization by Nontoxigenic Clostridioides difficile REA Strain M3 (NTCD-M3) Spores following Treatment with Either Fidaxomicin or Vancomycin

Autor: Susan P. Sambol, Andrew M. Skinner, Fidel Serna-Perez, Benjamin Owen, Dale N. Gerding, Stuart Johnson

Publikováno v: Microbiology Spectrum. 11

NTCD-M3 is a novel live biotherapeutic, that has been shown in a Phase 2 clinical trial to prevent recurrence of C. difficile infection (CDI) when administered shortly after antibiotic treatment of the initial CDI episode. Fidaxomicin was not, howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5502cc9c71528daeb1a9d642350218f6
https://doi.org/10.1128/spectrum.00517-23

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Characterization of Clostridioides difficile isolates recovered from two Phase 3 surotomycin treatment trials by restriction endonuclease analysis, PCR ribotyping and antimicrobial susceptibilities

Autor: Laurent Chesnel, Julia Nary, Adam Cheknis, Susan P Sambol, Richard V. Goering, Stuart Johnson, Dominique Devaris, Suzanne E. Dale, Diane M. Citron

Publikováno v: Journal of Antimicrobial Chemotherapy. 75:3120-3125

Objectives To investigate the molecular epidemiology and antimicrobial susceptibility of Clostridioides difficile isolates from patients with C. difficile infection (CDI) from two Phase 3 clinical trials of surotomycin. Methods In both trials [Protoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e924c18e5d4396a6b7e7737609cab0d7
https://doi.org/10.1093/jac/dkaa297

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Reinforcement of an infection control bundle targeting prevention practices for Clostridioides difficile in Veterans Health Administration nursing homes

Autor: Christopher W. Woods, Nan Hu, Susan M. Pacheco, Annette Jencson, Kalpana Gupta, Jeanmarie Mayer, Judith Strymish, David L. Johnson, Dale N. Gerding, Molly Leecaster, Nimalie D. Stone, Warren B. P. Pettey, Curtis J. Donskey, Matthew H. Samore, Susan P. Sambol, Edward J. Young, L. Clifford McDonald

Publikováno v: American Journal of Infection Control. 48:626-632

Background Clostridioides difficile infection (CDI) causes significant morbidity in nursing home residents. Our aim was to describe adherence to a bundled CDI prevention initiative, which had previously been deployed nationwide in Veterans Health Adm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e610c8021e1d62ed2a650c5522771e11
https://doi.org/10.1016/j.ajic.2019.09.019

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The Relative Role of Toxins A and B in the Virulence of Clotridioides difficile

Autor: S Tyler Phillips, Susan P. Sambol, Andrew M. Skinner, Kevin J. O'Leary, Stuart Johnson, Michelle M. Merrigan, Farida Siddiqui, Dale N. Gerding, Lance R. Peterson

Publikováno v: Journal of Clinical Medicine
Volume 10
Issue 1
Journal of Clinical Medicine, Vol 10, Iss 96, p 96 (2021)

Most pathogenic strains of C. difficile possess two large molecular weight single unit toxins with four similar functional domains. The toxins disrupt the actin cytoskeleton of intestinal epithelial cells leading to loss of tight junctions, which ult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e14479a85d3ed766673abdb831d104

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The Relative Role of Toxins A and B in the Virulence of

Autor: Andrew M, Skinner, S Tyler, Phillips, Michelle M, Merrigan, Kevin J, O'Leary, Susan P, Sambol, Farida, Siddiqui, Lance R, Peterson, Dale N, Gerding, Stuart, Johnson

Publikováno v: Journal of Clinical Medicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8cdec25b9dc134d58a721f6189ab62f3
https://pubmed.ncbi.nlm.nih.gov/33396595

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Efficacy of Bezlotoxumab in Trial Participants Infected With Clostridioides difficile Strain BI Associated With Poor Outcomes

Autor: Emma L. Best, Mary Beth Dorr, Ellie J. C. Goldstein, Karen Eves, Stuart Johnson, Susan P. Sambol, Mark H. Wilcox, Dale N. Gerding, Diane M. Citron, Erin Jensen

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 73(9)

Background Bezlotoxumab reduced rates of recurrent Clostridioides difficile infection (rCDI) vs placebo in Monoclonal Antibodies for C. difficile Therapy (MODIFY) I/II trial participants receiving antibacterial drug treatment for CDI. A secondary obj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa352d78497b755556a17625a258df1
https://pubmed.ncbi.nlm.nih.gov/32735653

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Unique Clindamycin-Resistant Clostridioides difficile Strain Related to Fluoroquinolone-Resistant Epidemic BI/RT027 Strain

Autor: Curtis J. Donskey, Stuart Johnson, Laurica A. Petrella, Susan P. Sambol, Farida Siddiqui, Christopher A. Gulvik, Dale N. Gerding, Andrew M Skinner

Publikováno v: Emerging Infectious Diseases
Emerging Infectious Diseases, Vol 26, Iss 2, Pp 247-254 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da78b4e9218d4babf422e751590a029
https://pubmed.ncbi.nlm.nih.gov/31961290

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Non-toxigenic Clostridioides (Formerly Clostridium) difficile for Prevention of C. difficile Infection: From Bench to Bedside Back to Bench and Back to Bedside

Autor: Stuart Johnson, Susan P. Sambol, Dale N. Gerding

Publikováno v: Frontiers in Microbiology
Frontiers in Microbiology, Vol 9 (2018)

The beneficial effect of colonization of the gastrointestinal tract by non-toxigenic Clostridioides difficile (NTCD) strains as a preventive of toxigenic C. difficile infection (CDI) has been known since the early 1980s. Investigators in both the USA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3850e14263ad064522edeb7322c4763a
http://europepmc.org/articles/PMC6070627

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