Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Susan P C Cole"'
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246727 (2021)
Multidrug resistance protein 1 (MRP1) (gene symbol ABCC1) is an ATP-binding cassette (ABC) transporter which effluxes xeno- and endobiotic organic anions including estradiol glucuronide and the pro-inflammatory leukotriene C4. MRP1 also confers multi
Externí odkaz:
https://doaj.org/article/b6b99fe0c92646039a0419da35d60f63
Autor:
Naoto Soya, Haijin Xu, Ariel Roldan, Zhengrong Yang, Haoxin Ye, Fan Jiang, Aiswarya Premchandar, Guido Veit, Susan P. C. Cole, John Kappes, Tamás Hegedüs, Gergely L. Lukacs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The folding/misfolding and pharmacological rescue of multidomain ATP-binding cassette (ABC) C-subfamily transporters, essential for organismal health, remain incompletely understood. The ABCC transporters core consists of two nucleotide bind
Externí odkaz:
https://doaj.org/article/26ee4a0b5ae048ff8a59c8ecf53a2afc
Autor:
Parameswaran G Sreekumar, Christine Spee, Stephen J Ryan, Susan P C Cole, Ram Kannan, David R Hinton
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33420 (2012)
Absence of α-crystallins (αA and αB) in retinal pigment epithelial (RPE) cells renders them susceptible to oxidant-induced cell death. We tested the hypothesis that the protective effect of α-crystallin is mediated by changes in cellular glutathi
Externí odkaz:
https://doaj.org/article/322fccd70f4c4e4c91e0bbbe39ccaacb
Autor:
null Kimberley M. Hanssen, null Madeleine S. Wheatley, null Denise M. T. Yu, null Gwenaëlle Conseil, null Murray D. Norris, null Michelle Haber, null Susan P. C. Cole, null Jamie I. Fletcher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeac1d467f2a5c00fd1e398deb44016c
https://doi.org/10.1111/febs.16374/v2/response1
https://doi.org/10.1111/febs.16374/v2/response1
Autor:
Kimberley M. Hanssen, Madeleine S. Wheatley, Denise M. T. Yu, Gwenaëlle Conseil, Murray D. Norris, Michelle Haber, Susan P. C. Cole, Jamie I. Fletcher
Publikováno v:
The FEBS journalReferences. 289(13)
MRP1 (ABCC1) is a membrane transporter that confers multidrug resistance in cancer cells by exporting chemotherapeutic agents, often in a reduced glutathione (GSH)-dependent manner. This transport activity can be altered by compounds (modulators) tha
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(10)
The human multidrug resistance protein 1 (hMRP1) transporter is implicated in cancer multidrug resistance as well as immune responses involving its physiologic substrate, glutathione (GSH)-conjugated leukotriene C
Autor:
Inka LEIER, Gabriele JEDLITSCHKY, Ulrike BUCHHOLZ, Melvin CENTER, Susan P. C. COLE, Roger G. DEELEY, Dietrich KEPPLER
Publikováno v:
Scopus-Elsevier
We have previously shown that the multidrug resistance protein (MRP) mediates the ATP-dependent membrane transport of the endogenous glutathione conjugate leukotriene C4 (LTC4) and of structurally related anionic conjugates of lipophilic compounds [J
Publikováno v:
Nucleic Acids Research
DNA topoisomerase (topo) II modulates DNA topology and is essential for cell division. There are two isoforms of topo II (alpha and beta) that have limited functional redundancy, although their catalytic mechanisms appear the same. Using their COOH-t
Publikováno v:
The Journal of biological chemistry. 278(46)
Human multidrug resistance protein 1 (MRP1) confers resistance to many chemotherapeutic agents and transports diverse conjugated organic anions. We previously demonstrated that Glu1089 in transmembrane (TM) 14 is critical for the protein to confer an
Autor:
Qingcheng, Mao, Wei, Qiu, Kevin E, Weigl, Peter A, Lander, Linda B, Tabas, Robert L, Shepard, Anne H, Dantzig, Roger G, Deeley, Susan P C, Cole
Publikováno v:
The Journal of biological chemistry. 277(32)
Substrates transported by the 190-kDa multidrug resistance protein 1 (MRP1) (ABCC1) include endogenous organic anions such as the cysteinyl leukotriene C(4). In addition, MRP1 confers resistance against various anticancer drugs by reducing intracellu