Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Susan N Thomas"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Tumor-draining lymph nodes (TdLNs) are critical in the regulation of local and systemic antitumor T cell immunity and are implicated in coordinating responses to immunomodulatory therapies.Methods Biomaterial nanoparticles that deliver che
Externí odkaz:
https://doaj.org/article/3fa5f1ebad2d4f6a9079cdc62f66252e
Autor:
Sruthi Ravindranathan, Tenzin Passang, Jian-Ming Li, Shuhua Wang, Rohan Dhamsania, Michael Brandon Ware, Mohammad Y. Zaidi, Jingru Zhu, Maria Cardenas, Yuan Liu, Sanjeev Gumber, Brian Robinson, Anish Sen-Majumdar, Hanwen Zhang, Shanmuganathan Chandrakasan, Haydn Kissick, Alan B. Frey, Susan N. Thomas, Bassel F. El-Rayes, Gregory B. Lesinski, Edmund K. Waller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Poor antitumor response of pancreatic cancer to immunotherapies is a major barrier to effective disease management. Herein we show that pancreatic cancers overexpress vasoactive intestinal peptide, and pharmacological inhibition of its signaling sign
Externí odkaz:
https://doaj.org/article/954e43b7b1f84c9eb8712e29586d1565
Autor:
Jihoon Kim, David M. Francis, Lauren F. Sestito, Paul A. Archer, Margaret P. Manspeaker, Meghan J. O’Melia, Susan N. Thomas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Nitric oxide exerts a multitude of physiological functions and has also been exploited for anticancer therapies. Here the authors report the design of a micelle-releasing thermosensitive hydrogel system for the concomitant locoregional and lymphatic
Externí odkaz:
https://doaj.org/article/955df8be82f34fec86bf0913efa76330
Autor:
Camila P. Camargo, Abir K. Muhuri, Yunus Alapan, Lauren F. Sestito, Megha Khosla, Margaret P. Manspeaker, Aubrey S. Smith, Chrystal M. Paulos, Susan N. Thomas
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112175- (2023)
Summary: CD8+ T cell recruitment to the tumor microenvironment is critical for the success of adoptive cell therapy (ACT). Unfortunately, only a small fraction of transferred cells home to solid tumors. Adhesive ligand-receptor interactions have been
Externí odkaz:
https://doaj.org/article/b4f20bae16a84fccbccc5487a170cc42
Publikováno v:
iScience, Vol 22, Iss , Pp 28-43 (2019)
Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here we review the functional role of lymphatic transport and lymph no
Externí odkaz:
https://doaj.org/article/30300c4056f640c083bd303d3f2835bb
Autor:
Jihoon Kim, Paul A. Archer, Margaret P. Manspeaker, Alexa R.C. Avecilla, Brian P. Pollack, Susan N. Thomas
Publikováno v:
Journal of Controlled Release. 357:655-668
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13850ea6610c8510bb5c4bfc359966f7
https://doi.org/10.1016/j.jconrel.2023.04.028
https://doi.org/10.1016/j.jconrel.2023.04.028
Autor:
Katherine G. Birmingham, Meghan J. O'Melia, Samantha Bordy, David Reyes Aguilar, Bassel El-Reyas, Gregory Lesinski, Susan N. Thomas
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101751- (2020)
Summary: A lymph node sinus-on-a-chip adhesion microfluidic platform that recapitulates the hydrodynamic microenvironment of the lymph node subcapsular sinus was engineered. This device was used to interrogate the effects of lymph node remodeling on
Externí odkaz:
https://doaj.org/article/0d1706a2b93d47d7af57dd64d649ac94
Autor:
Jihoon Kim, Susan N. Thomas
Publikováno v:
Pharmacological Reviews. 74:1146-1175
Despite nearly 30 years of development and recent highlights of nitric oxide (NO) donors and NO delivery systems in anticancer therapy, the limited understanding of exogenous NO's effects on the immune system has prevented their advancement into clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16e3be0063a2d834abbc2fa7e76b148
https://doi.org/10.1124/pharmrev.121.000500
https://doi.org/10.1124/pharmrev.121.000500
Publikováno v:
Annual Review of Biomedical Engineering. 25
Accompanying the increasing translational impact of immunotherapeutic strategies to treat and prevent disease has been a broadening interest across both bioscience and bioengineering in the lymphatic system. Herein, the lymphatic system physiology, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48de4be81f66a6eb54b4698b5c575e8f
https://doi.org/10.1146/annurev-bioeng-092222-034906
https://doi.org/10.1146/annurev-bioeng-092222-034906
Autor:
Lauren F. Sestito, Kim H. T. To, Matthew T. Cribb, Paul A. Archer, Susan N. Thomas, J. Brandon Dixon
Publikováno v:
Science Advances. 9
Dysfunction of collecting lymphatic vessel pumping is associated with an array of pathologies. S-(−)-Bay K8644 (BayK), a small-molecule agonist of L-type calcium channels, improves vessel contractility ex vivo but has been left unexplored in vivo b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::613f5662b59b57b499ee854a44838710
https://doi.org/10.1126/sciadv.abq0435
https://doi.org/10.1126/sciadv.abq0435