Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Susan Molleran, Lee"'
Autor:
Janos Sumegi, Joyce Villanueva, Alexandra H. Filipovich, Alexei A. Grom, Michael G. Barnes, Kimberly A. Risma, Susan Molleran-Lee, Kejian Zhang, Shawnagay Nestheide
Publikováno v:
Blood
Familial hemophagocytic lymphohistiocytosis (FHL) is a rare, genetically heterogeneous autosomal recessive immune disorder that results when the critical regulatory pathways that mediate immune defense mechanisms and the natural termination of immune
Autor:
Claire A. Chougnet, Lisa Neumeier, Peter Szigligeti, Susan Molleran Lee, Alexandra H. Filipovich, Koichi Takimoto, Eugene Duke, Laura Conforti
Publikováno v:
The Journal of Physiology. 573:357-370
T lymphocytes encounter hypoxia when they migrate to pathological sites such as tumours and wounds. The inability of T cells to provide an efficient defence at these sites can in part be explained by the hypoxic environment. Kv 1.3 channels, importan
Autor:
Lisa Neumeier, Peter Szigligeti, Alexandra H. Filipovich, Milan Petrovic, Susan Molleran Lee, Laura Conforti, Jennifer R. Robbins
Publikováno v:
The Journal of Physiology. 564:131-143
T lymphocytes are exposed to hypoxia during their development and when they migrate to hypoxic pathological sites. Although it has been shown that hypoxia inhibits Kv1.3 channels and proliferation in human T cells, the mechanisms by which hypoxia reg
Autor:
Jeanette Pullen, S.M. Davies, Susan Molleran Lee, Joyce Villanueva, Ashok Kumar, Alexandra H. Filipovich, Tiffany A. Zamzow, Parinda A. Mehta, Meenakshi Devidas, James Elliott, Y Zewge
Publikováno v:
Leukemia. 20:1539-1541
Perforin plays a key role in the cytotoxicity of natural killer and cytotoxic T cells. Genetic mutations in the perforin gene (PRF1) give rise to approximately 30% cases of familial hemophagocytic lymphohistiocytosis. A frequent polymorphism, A91V (C
Autor:
Stella A. Nicolaou, Heather J. Duncan, Mongey Ab, Lisa Neumeier, Alexandra H. Filipovich, Laura Conforti, Shashi K. Kant, Koichi Takimoto, Susan Molleran Lee
Publikováno v:
The FASEB Journal. 22
Systemic lupus erythematosus (SLE) T cells exhibit several activation signaling anomalies including defective Ca(2+) response and increased NF-AT nuclear translocation. The duration of the Ca(2+) signal is critical in the activation of specific trans
Autor:
Lisa Neumeier, Shashi K. Kant, Alexandra H. Filipovich, Laura Conforti, Mongey Ab, Stella A. Nicolaou, Heather J. Duncan, Susan Molleran Lee, Peter Szigligeti
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 179(1)
Aberrant T cell responses during T cell activation and immunological synapse (IS) formation have been described in systemic lupus erythematosus (SLE). Kv1.3 potassium channels are expressed in T cells where they compartmentalize at the IS and play a
Autor:
Aarati Rao, Susan Molleran Lee, Alexandra H. Filipovich, Naynesh Kamani, Stella M. Davies, Shalini Shenoy, Jignesh Dalal
Publikováno v:
Blood. 109(1)
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare, fatal autoimmune disorder caused by mutations in the FOXP3 gene leading to the disruption of signaling pathways involved in regulatory T-lymphocyte function. L
Autor:
Peter, Szigligeti, Lisa, Neumeier, Eugene, Duke, Claire, Chougnet, Koichi, Takimoto, Susan Molleran, Lee, Alexandra H, Filipovich, Laura, Conforti
Publikováno v:
The Journal of physiology. 573(Pt 2)
T lymphocytes encounter hypoxia when they migrate to pathological sites such as tumours and wounds. The inability of T cells to provide an efficient defence at these sites can in part be explained by the hypoxic environment. Kv 1.3 channels, importan
Autor:
Susan Molleran Lee, Yasuhiro Tabata, Xiaohua Sheng, Rita Clementi, Genevieve de Saint Basile, Joyce Villanueva, Ranajit Chakraborty, Kejian Zhang, Janos Sumegi, Alexandra H. Filipovich
Publikováno v:
The Journal of pediatrics. 149(1)
Mutations of the perforin gene (PRF1) are present in a proportion of patients with hemophagocytic lymphohistiocytosis (HLH). We found that all identified infants with HLH of African descent (17 from USA, 4 from Europe) have 50delT-PRF1 (16 homozygote
Autor:
Jennifer R, Robbins, Susan Molleran, Lee, Alexandra H, Filipovich, Peter, Szigligeti, Lisa, Neumeier, Milan, Petrovic, Laura, Conforti
Publikováno v:
The Journal of physiology. 564(Pt 1)
T lymphocytes are exposed to hypoxia during their development and when they migrate to hypoxic pathological sites. Although it has been shown that hypoxia inhibits Kv1.3 channels and proliferation in human T cells, the mechanisms by which hypoxia reg