Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Susan Mathers"'
Publikováno v:
BMJ Neurology Open, Vol 6, Iss Suppl 1 (2024)
Externí odkaz:
https://doaj.org/article/e3f2379767e5424cb5bbd9a399d93eef
Autor:
David J. Berlowitz, Susan Mathers, Karen Hutchinson, Anne Hogden, Kate A. Carey, Marnie Graco, Brooke-Mai Whelan, Salma Charania, Frederik Steyn, Peter Allcroft, Ashley Crook, Nicole L. Sheers
Publikováno v:
Breathe, Vol 19, Iss 3 (2023)
Motor neurone disease/amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no known cure, where death is usually secondary to progressive respiratory failure. Assisting people with ALS through their disease journey is
Externí odkaz:
https://doaj.org/article/0d7d7b55997e4f77a217f91e6c49ade0
Autor:
Restuadi Restuadi, Frederik J. Steyn, Edor Kabashi, Shyuan T. Ngo, Fei-Fei Cheng, Marta F. Nabais, Mike J. Thompson, Ting Qi, Yang Wu, Anjali K. Henders, Leanne Wallace, Chris R. Bye, Bradley J. Turner, Laura Ziser, Susan Mathers, Pamela A. McCombe, Merrilee Needham, David Schultz, Matthew C. Kiernan, Wouter van Rheenen, Leonard H. van den Berg, Jan H. Veldink, Roel Ophoff, Alexander Gusev, Noah Zaitlen, Allan F. McRae, Robert D. Henderson, Naomi R. Wray, Jean Giacomotto, Fleur C. Garton
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-22 (2022)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a complex, late-onset, neurodegenerative disease with a genetic contribution to disease liability. Genome-wide association studies (GWAS) have identified ten risk loci to date, including the
Externí odkaz:
https://doaj.org/article/554d6d92682e49b2a277f81cb79542d2
Autor:
Steve Vucic, Robert D. Henderson, Susan Mathers, Merrilee Needham, David Schultz, Matthew C. Kiernan, the TEALS study group
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 10, Pp 1991-1999 (2021)
Abstract Objective Neuroinflammation is an important pathogenic mechanism in amyotrophic lateral sclerosis (ALS), with regulatory T cells (Tregs) mediating a slower rate of disease progression. Dimethyl fumarate enhances Treg levels and suppresses pr
Externí odkaz:
https://doaj.org/article/9927dc898a6147fc81a915681161ba65
Autor:
Marta F. Nabais, Simon M. Laws, Tian Lin, Costanza L. Vallerga, Nicola J. Armstrong, Ian P. Blair, John B. Kwok, Karen A. Mather, George D. Mellick, Perminder S. Sachdev, Leanne Wallace, Anjali K. Henders, Ramona A. J. Zwamborn, Paul J. Hop, Katie Lunnon, Ehsan Pishva, Janou A. Y. Roubroeks, Hilkka Soininen, Magda Tsolaki, Patrizia Mecocci, Simon Lovestone, Iwona Kłoszewska, Bruno Vellas, the Australian Imaging Biomarkers and Lifestyle study, the Alzheimer’s Disease Neuroimaging Initiative, Sarah Furlong, Fleur C. Garton, Robert D. Henderson, Susan Mathers, Pamela A. McCombe, Merrilee Needham, Shyuan T. Ngo, Garth Nicholson, Roger Pamphlett, Dominic B. Rowe, Frederik J. Steyn, Kelly L. Williams, Tim J. Anderson, Steven R. Bentley, John Dalrymple-Alford, Javed Fowder, Jacob Gratten, Glenda Halliday, Ian B. Hickie, Martin Kennedy, Simon J. G. Lewis, Grant W. Montgomery, John Pearson, Toni L. Pitcher, Peter Silburn, Futao Zhang, Peter M. Visscher, Jian Yang, Anna J. Stevenson, Robert F. Hillary, Riccardo E. Marioni, Sarah E. Harris, Ian J. Deary, Ashley R. Jones, Aleksey Shatunov, Alfredo Iacoangeli, Wouter van Rheenen, Leonard H. van den Berg, Pamela J. Shaw, Cristopher E. Shaw, Karen E. Morrison, Ammar Al-Chalabi, Jan H. Veldink, Eilis Hannon, Jonathan Mill, Naomi R. Wray, Allan F. McRae
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-30 (2021)
Abstract Background People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) provides a way to e
Externí odkaz:
https://doaj.org/article/201eefeb04d04cf0871060b72f55eedd
Autor:
Anjan Bhattarai, Zhaolin Chen, Phyllis Chua, Paul Talman, Susan Mathers, Caron Chapman, James Howe, C M Sarah Lee, Yenni Lie, Govinda R Poudel, Gary F Egan
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272736 (2022)
ObjectiveEmerging evidences suggest that the trans-neural propagation of phosphorylated 43-kDa transactive response DNA-binding protein (pTDP-43) contributes to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). We investigated whether Network
Externí odkaz:
https://doaj.org/article/cfcaec36b91f4ea4a09852b8ab6a901a
Publikováno v:
BMJ Neurology Open, Vol 3, Iss 2 (2021)
Background Bulbar involvement is a recognised feature of motor neuron disease/amyotrophic lateral sclerosis (MND/ALS), both as a presenting complaint and as a consequence of advancing disease. Hoarseness and dysphonia have been associated with vocal
Externí odkaz:
https://doaj.org/article/b59300dbe9ea4ef094cda2c9cbf88b13
Publikováno v:
Healthcare, Vol 10, Iss 8, p 1371 (2022)
The growing body of information-seeking and decision-making literature in motor neurone disease (MND) has not yet explored the impact of health literacy. Health literacy relates to the skills people have to access, understand, and use health informat
Externí odkaz:
https://doaj.org/article/bc9816214dca40ddbb314bd4197cc53d
Autor:
Nicholas P. Ryan, Laura Scott, Maryanne McPhee, Susan Mathers, Marie-Claire Davis, Roxanne Maule, Fiona Fisher
Publikováno v:
Behavioural Neurology, Vol 2018 (2018)
Objectives. Behavioural and psychological symptoms of dementia (BPSD) cause significant distress to both aged care residents and staff. Despite the high prevalence of BPSD in progressive neurological diseases (PNDs) such as multiple sclerosis, Huntin
Externí odkaz:
https://doaj.org/article/e7f09c74dc0a463ebfaaa7a47ce8d327
Autor:
Andrew Hannaford, Karen Byth, Nathan Pavey, Robert D. Henderson, Susan Mathers, Merrilee Needham, David Schultz, Parvathi Menon, Matthew C. Kiernan, Steve Vucic
Publikováno v:
Muscle & Nerve. 67:17-24
Rate of disease progression (ΔFS), measured as change in the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) and body mass index (BMI), are predictors of survival in amyotrophic lateral sclerosis (ALS). Our aim in this study