Amyloid β-Protein Induces Its Own Production in Cultured Degenerating Cerebrovascular Smooth Muscle Cells

Autor: Carl W. Cotman, Susan M. Saporito-irwin, W E Van Nostrand, J Davis-Salinas

Publikováno v: Journal of Neurochemistry. 65:931-934

The progression of Alzheimer's disease and related disorders involves amyloid beta-protein (A beta) deposition and pathologic changes in the parenchyma as well as cerebral blood vessels. The cerebrovascular A beta deposits in these disorders are asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7506349fda00e18a31b38820285b1365
https://doi.org/10.1046/j.1471-4159.1995.65020931.x

Amyloid $sZ-protein stimulates parallel increases in cellular levels of its precursor and amyloid precursor-like protein 2 (APLP2) in human cerebrovascular smooth muscle cells

Autor: Gopal Thinakaran, Sangram S. Sisodia, William E. Van Nostrand, Lynda Ruffini, Susan M. Saporito-irwin

Publikováno v: Amyloid. 4:54-60

The amyloid β-protein (Aβ) which accumulates in cerebral vascular and senile plaque deposits in the brains of patients with Alzheimer's disease (AD) is proteolytically derived from a larger precursor protein, the amyloid β-protein precursor (AβPP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e36871e8caacec19c2feda4a6aa2b6e6
https://doi.org/10.3109/13506129708995270

Amyloid βprotein precursor in cultured leptomeningeal smooth muscle cells

Autor: Raymond T. Chung, Carl W. Cotman, Susan M. Saporito-irwin, Annemieke J. M. Rozemuller, William E. Van Nostrand

Publikováno v: Van Nostrand, W E, Rozemuller, A J M, Chung, R, Cotman, C W & Saporito-Irwin, S M 1994, ' Amyloid βprotein precursor in cultured leptomeningeal smooth muscle cells ', Amyloid, vol. 1, no. 1, pp. 1-7 . https://doi.org/10.3109/13506129409148618
Amyloid, 1(1), 1-7. Informa Healthcare

Smooth muscle cell cultures were established from human leptomeningeal blood vessels obtained at autopsy from a patient with normal cortical blood vessels and a patient with extensive cerebral amyloid angiopathy (CAA). The normal leptomeningeal smoot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6194de6d67acc5e6cd4bd0e80de07aea
http://www.scopus.com/inward/record.url?scp=0001960660&partnerID=8YFLogxK

Coagulation factor XIa cleaves the RHDS sequence and abolishes the cell adhesive properties of the amyloid beta-protein

Autor: William E. Van Nostrand, Susan M. Saporito-irwin

Publikováno v: The Journal of biological chemistry. 270(44)

Amyloid beta-protein (A beta) is the major constituent of senile plaques and cerebrovascular amyloid deposits in Alzheimer's disease and is proteolytically derived from its transmembrane parent protein the amyloid beta-protein precursor (A beta PP).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e0663c9d22b948da7eff3e6b668d8d
https://pubmed.ncbi.nlm.nih.gov/7592834