The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster.

Autor: Robert L Unckless, Susan M Rottschaefer, Brian P Lazzaro

Publikováno v: PLoS Genetics, Vol 11, Iss 3, p e1005030 (2015)

Both malnutrition and undernutrition can lead to compromised immune defense in a diversity of animals, and "nutritional immunology" has been suggested as a means of understanding immunity and determining strategies for fighting infection. The genetic

Externí odkaz: https://doaj.org/article/2a42e17a7d194c1fb8ce78c93bfe70aa

Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 malaria resistance genes of Anopheles gambiae.

Autor: Susan M Rottschaefer, Michelle M Riehle, Boubacar Coulibaly, Madjou Sacko, Oumou Niaré, Isabelle Morlais, Sekou F Traoré, Kenneth D Vernick, Brian P Lazzaro

Publikováno v: PLoS Biology, Vol 9, Iss 3, p e1000600 (2011)

The three-gene APL1 locus encodes essential components of the mosquito immune defense against malaria parasites. APL1 was originally identified because it lies within a mapped QTL conferring the vector mosquito Anopheles gambiae natural resistance to

Externí odkaz: https://doaj.org/article/e1aa143f9d214e0fa582003732c066f0

Detection of race-specific resistance against Puccinia coronata f. sp. avenae in Brachypodium species

Autor: Feng Li, Michael Ayliffe, Susan M. Rottschaefer, Vahid Omidvar, Melania Figueroa, Sheshanka Dugyala, Marisa E. Miller, Matthew J. Moscou, Shahryar F. Kianian

Oat crown rust caused by Puccinia coronata f. sp. avenae is the most destructive foliar disease of cultivated oat. Characterization of genetic factors controlling resistance responses to Puccinia coronata f. sp. avenae in non-host species could provi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f44009c33cb5a2adb3cde609286516
https://doi.org/10.1101/281568

No evidence for positive selection at two potential targets for malaria transmission-blocking vaccines in Anopheles gambiae s.s

Autor: Susan M. Rottschaefer, Brian P. Lazzaro, Oumou Niaré, Boubacar Coulibaly, Sekou F. Traore, Kenneth D. Vernick, Jacob E. Crawford, Michelle M. Riehle, Madjou Sacko

Publikováno v: Infection, Genetics and Evolution
Infection, Genetics and Evolution, 2013, 16, pp.87--92. ⟨10.1016/j.meegid.2013.01.006⟩
Infection, Genetics and Evolution, Elsevier, 2013, 16, pp.87--92. ⟨10.1016/j.meegid.2013.01.006⟩

International audience; Human malaria causes nearly a million deaths in sub-Saharan Africa each year. The evolution of drug-resistance in the parasite and insecticide resistance in the mosquito vector has complicated control measures and made the nee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e33fdb67c544f12e75a55032b750c6
https://doi.org/10.1016/j.meegid.2013.01.006

Population genetics of Anopheles coluzzii immune pathways and genes

Autor: Kenneth D. Vernick, N’Fale Sagnon, Brian P. Lazzaro, Wamdaogo M. Guelbeogo, Awa Gneme, Michelle M. Riehle, Jacob E. Crawford, Susan M. Rottschaefer

Publikováno v: G3
G3, Genetics Society of America, 2014, 5 (3), pp.329--339. ⟨10.1534/g3.114.014845⟩
G3: Genes|Genomes|Genetics
G3, 2014, 5 (3), pp.329--339. ⟨10.1534/g3.114.014845⟩

Natural selection is expected to drive adaptive evolution in genes involved in host–pathogen interactions. In this study, we use molecular population genetic analyses to understand how natural selection operates on the immune system of Anopheles co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b21eb612c06b82d96b41f7e426f1ea
https://hal-pasteur.archives-ouvertes.fr/pasteur-02008324/document