Výsledky vyhledávání - "Susan M. Rookes"

T-cell responses to human papillomavirus type 16 among women with different grades of cervical neoplasia

Autor: Sally Roberts, Phillip H. Gallimore, Terence Rollason, Susan M. Rookes, MG Freeth, Christopher H. Mann, Jane C. Steele, Damian Murphy

Publikováno v: British Journal of Cancer

Infection with high-risk genital human papillomavirus (HPV) types is a major risk factor for the development of cervical intraepithelial neoplasia (CIN) and invasive cervical carcinoma. The design of effective immunotherapies requires a greater under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdeaa6ca5c2feecbe5524c3fdac8b0c2
http://europepmc.org/articles/PMC2361543

Zobrazit plný text záznamu

Detection of CD4 + - and CD8 + -T-Cell Responses to Human Papillomavirus Type 1 Antigens Expressed at Various Stages of the Virus Life Cycle by Using an Enzyme-Linked Immunospot Assay of Gamma Interferon Release

Autor: Jane C. Steele, Susan M. Rookes, Phillip H. Gallimore, Sally Roberts

Publikováno v: Journal of Virology. 76:6027-6036

Human papillomavirus (HPV) antigens are expressed in epithelial cells at different stages of differentiation, and this may affect how they are handled by the immune system. We assessed the relative immunogenicities of four different HPV type 1 protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c3b4a47f635bac694e0d9da5daa2642
https://doi.org/10.1128/jvi.76.12.6027-6036.2002

Zobrazit plný text záznamu

Definition of a major p53 binding site on Ad2E1B58K protein and a possible nuclear localization signal on the Ad12E1B54K protein

Autor: Tadge Szestak, Roger J.A. Grand, Julian Parkhill, Phillip H. Gallimore, Susan M. Rookes, Sally Roberts

Publikováno v: Oncogene. 18:955-965

Previous studies have established that adenovirus 2/5 early region 1B (Ad E1B) 58K protein binds p53 strongly and co-localizes with it to cytoplasmic dense bodies whilst the homologous Ad12E1B54K protein binds only weakly and co-localizes primarily t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4c59d706190761de3df19551f87111
https://doi.org/10.1038/sj.onc.1202358

Zobrazit plný text záznamu

The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression

Autor: Ashley Martin, Susan M. Rookes, Andrew S. Turnell, Roger J.A. Grand, Grant S. Stewart, Phillip H. Gallimore, Hiroyuki Yamano, Stephen J. Elledge

Publikováno v: Nature. 438(7068)

The anaphase-promoting complex/cyclosome (APC/C) is a multicomponent E3 ubiquitin ligase that, by targeting protein substrates for 26S proteasome-mediated degradation through ubiquitination, coordinates the temporal progression of eukaryotic cells th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc5dd0fc9256963fa641ca97694be73
https://pubmed.ncbi.nlm.nih.gov/16319895

Zobrazit plný text záznamu

Detection of CD4(+)- and CD8(+)-T-cell responses to human papillomavirus type 1 antigens expressed at various stages of the virus life cycle by using an enzyme-linked immunospot assay of gamma interferon release

Autor: Jane C, Steele, Sally, Roberts, Susan M, Rookes, Phillip H, Gallimore

Publikováno v: Journal of virology. 76(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27b7697ad5652e1352264d24b2935003
https://pubmed.ncbi.nlm.nih.gov/12021335

Zobrazit plný text záznamu

Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasome

Autor: Andrew S. Turnell, Phillip H. Gallimore, A. J. Rivett, Joe S. Mymryk, Richard J. Grand, Susan M. Rookes, Anne E. Milner, G. G. F. Mason, W. Wang

Publikováno v: Oncogene. 18(2)

Adenovirus early region 1A (Ad E1A) is a multifunctional protein which is essential for adenovirus-mediated transformation and oncogenesis. Whilst E1A is generally considered to exert its influence on recipient cells through regulation of transcripti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077c3913867a730379a1cd142f045f1d
https://pubmed.ncbi.nlm.nih.gov/9927201

Zobrazit plný text záznamu

Mutational analysis of the human papillomavirus type 16 E1--E4 protein shows that the C terminus is dispensable for keratin cytoskeleton association but is involved in inducing disruption of the keratin filaments

Autor: Sally Roberts, Phillip H. Gallimore, Ian Ashmole, Susan M. Rookes

Publikováno v: Journal of virology. 71(5)

The function of the human papillomavirus (HPV) E4 proteins is unknown. In cultured epithelial cells the proteins associate with the keratin intermediate filaments (IFs) and, for some E4 types, e.g., HPV type 16 (HPV-16), induce collapse of the kerati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5403aa3aeef50278cf8d0baf0d58d3ae
https://pubmed.ncbi.nlm.nih.gov/9094627

Zobrazit plný text záznamu

Mutational analysis of human papillomavirus E4 proteins: identification of structural features important in the formation of cytoplasmic E4/cytokeratin networks in epithelial cells

Autor: Susan M. Rookes, Phillip H. Gallimore, Sally Roberts, Ian Ashmole, Geoff J. Barton, Loretta J. Gibson

We have previously demonstrated that human papillomavirus type 1 (HPV 1) and 16 (HPV 16) E4 proteins form cytoplasmic filamentous networks which specifically colocalize with cytokeratin intermediate-filament (IF) networks when expressed in simian vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d27c53417665a71b4362df5fd5cc316
https://europepmc.org/articles/PMC237063/

Zobrazit plný text záznamu

Three transcriptionally distinct forms of Epstein-Barr virus latency in somatic cell hybrids: cell phenotype dependence of virus promoter usage

Autor: Martin Rowe, D. Croom-Carter, B.M. Kerr, Philip H. Gallimore, Lawrence S. Young, Alan B. Rickinson, A L Lear, Susan M. Rookes

Publikováno v: Virology. 187(1)

Phenotypically distinct human B cell lines display two transcriptionally distinct forms of Epstein-Barr virus (EBV) latency. Latency I (Lat I) in group I Burkitt's lymphoma (BL) cell lines is characterized by selective expression of the virus-coded n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f59c911a4493ef9d134626c3cfa167
https://pubmed.ncbi.nlm.nih.gov/1310556

Zobrazit plný text záznamu

Control of p53 Expression by Adenovirus 12 Early Region 1A and Early Region 1B 54K Proteins

Autor: Phillip H. Gallimore, Roger J.A. Grand, Susan M. Rookes, Darerca Owen

Publikováno v: Virology. (1):23-34

The level of p53 is markedly increased in human cells in response to expression of the Ad12 E1A proteins and, quite separately, to the Ad12 E1B 54K protein. The behaviour of p53 in these two circumstances has been examined using A549 cells infected w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db275c94ed8a04c944be288c97fb30fa

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání